B6IBD2 (YDIB_ECOSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Quinate/shikimate dehydrogenase
EC=1.1.1.282

Alternative name(s):
NAD-dependent shikimate 5-dehydrogenase 2

Gene names

Name:	ydiB
Ordered Locus Names:	ECSE_1815

Organism

Escherichia coli (strain SE11) [Complete proteome] [HAMAP]

Taxonomic identifier

409438 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H. HAMAP MF_01578 Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H. HAMAP MF_01578
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_01578
Subunit structure	Homodimer By similarity. HAMAP MF_01578
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro quinate 3-dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC quinate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC shikimate 3-dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Quinate/shikimate dehydrogenase HAMAP MF_01578		PRO_1000147553
Regions
	Nucleotide binding	131 – 135	5	NAD By similarity
	Nucleotide binding	155 – 158	4	NAD By similarity
	Nucleotide binding	255 – 259	5	NAD By similarity
Sites
	Active site	71	1	Proton acceptor Potential
	Binding site	107	1	Substrate By similarity
	Binding site	205	1	NAD; via amide nitrogen By similarity
	Binding site	235	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6IBD2 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 3B606A7CB1A92F36	FASTA	288	31,242
	10 20 30 40 50 60 MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPFTYM AFEVDNDSFP GAIEGLKALK 70 80 90 100 110 120 MRGTGISMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY LRGYNTDGTG HIRAIKESGF 130 140 150 160 170 180 DIKGKTMVLL GAGGASTAIG AQGAIEGLKE IKLFNRRDEF FDKALAFAQR VNENTDCVVT 190 200 210 220 230 240 VTDLADQQAF AEALASADIL TNGTKVGMKP LENESLVNDI SLLHPGLLVT ECVYNPHMTK 250 260 270 280 LLQQAQQAGC KTIDGYGMLL WQGAEQFTLW TGKDFPLEYV KQVMGFGA

References

[1]

"Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult." Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M. DNA Res. 15:375-386(2008) [PubMed: 18931093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SE11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009240 Genomic DNA. Translation: BAG77339.1.
RefSeq	YP_002293090.1. NC_011415.1.
3D structure databases
ProteinModelPortal	B6IBD2.
SMR	B6IBD2. Positions 1-288.
ModBase	Search...
Protein-protein interaction databases
STRING	B6IBD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000107674; EBESCP00000100290; EBESCG00000109878.
GeneID	7000193.
GenomeReviews	Gene locus ECSE_1815 in contig AP009240_GR.
KEGG	ecy:ECSE_1815.
PATRIC	18422132. VBIEscCol83070_1961.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000010797.
HOGENOM	HBG553408.
OMA	GSFAMPA.
ProtClustDB	PRK12749.
Enzyme and pathway databases
BioCyc	ECOL409438:ECSE_1815-MONOMER.
Family and domain databases
HAMAP	MF_01578. Shikimate_DH_YdiB. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR022872. Quinate/Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K05887.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YDIB_ECOSE

Accession

Primary (citable) accession number: B6IBD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program