Reviewed, UniProtKB/Swiss-Prot B6IAS4 (UXAB_ECOSE)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	ECSE_1611

Organism

Escherichia coli (strain SE11) [Complete proteome] [HAMAP]

Taxonomic identifier

409438 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase HAMAP MF_00670		PRO_1000131511
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6IAS4-1 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: ABF5226CB25CC297	FASTA	483	54,822
	10 20 30 40 50 60 MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV VRPIETSFPP 70 80 90 100 110 120 SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS EYDEFLKLAH NPEMRFVFSN 130 140 150 160 170 180 TTEAGISYHA GDKFDDAPAV SYPAKLTRLL FERFSHFNGA LDKGWIIIPC ELIDYNGDAL 190 200 210 220 230 240 RELVLRYAQE WALPEAFIQW LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT 250 260 270 280 290 300 AEHFYLFVIQ GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 310 320 330 340 350 360 LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP YIKHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLAGQK AKGTLPARLT FALAALIAFY RGERNGETYP VQDDAHWLER 430 440 450 460 470 480 YQQLWSQHRD RVIGTQELVA IVLAEKDHWE QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC

References

[1]

"Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult." Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M. DNA Res. 15:375-386(2008) [PubMed: 18931093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009240 Genomic DNA. Translation: BAG77135.1.
RefSeq	YP_002292886.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6999982.
GenomeReviews	Gene locus ECSE_1611 in contig AP009240_GR.
KEGG	ecy:ECSE_1611.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SIFPCEL.
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_ECOSE

Accession

Primary (citable) accession number: B6IAS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 16, 2008
Last modified:	November 3, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)