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B6I9I5

- NAGZ_ECOSE

UniProt

B6I9I5 - NAGZ_ECOSE

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Protein
Beta-hexosaminidase
Gene
nagZ, ECSE_1172
Organism
Escherichia coli (strain SE11)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Sitei174 – 1741Important for catalytic activity By similarity
Active sitei176 – 1761Proton donor/acceptor By similarity
Active sitei248 – 2481Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciECOL409438:GHUU-1198-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:ECSE_1172
OrganismiEscherichia coli (strain SE11)
Taxonomic identifieri409438 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008199: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Beta-hexosaminidaseUniRule annotation
PRO_1000121059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi409438.ECSE_1172.

Structurei

3D structure databases

ProteinModelPortaliB6I9I5.
SMRiB6I9I5. Positions 1-324.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiAHDIDLS.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6I9I5-1 [UniParc]FASTAAdd to Basket

« Hide

MGPVMLDVKG YELDAEEREI LAHPLVGGLI LFTRNYHDPA QLRELVRQIR    50
AASRNHLVVA VDQEGGRVQR FREGFTRLPA AQSFAALSGM EEGGKLAQEA 100
GWLMASEMIA MDIDISFAPV LDVGHISAAI GERSYHADPQ KALAIASRFI 150
DGMHEAGMKT TGKHFPGHGA VTADSHKETP CDPRPQAEIR AKDMSVFSSL 200
IRENKLDAIM PAHVIYSDVD PRPASGSPYW LKTVLRQELG FDGVIFSDDL 250
SMEGAAIMGS YAERGQASLD AGCDMILVCN NRKGAVSVLD NLSPIKAERV 300
TRLYHKGSFS RQELMDSARW KAISTRLNQL HERWQEEKAG H 341
Length:341
Mass (Da):37,575
Last modified:December 16, 2008 - v1
Checksum:i4655EF360F7AAC00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG76696.1.
RefSeqiYP_002292447.1. NC_011415.1.

Genome annotation databases

EnsemblBacteriaiBAG76696; BAG76696; ECSE_1172.
GeneIDi6999543.
KEGGiecy:ECSE_1172.
PATRICi18420816. VBIEscCol83070_1307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG76696.1 .
RefSeqi YP_002292447.1. NC_011415.1.

3D structure databases

ProteinModelPortali B6I9I5.
SMRi B6I9I5. Positions 1-324.
ModBasei Search...

Protein-protein interaction databases

STRINGi 409438.ECSE_1172.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG76696 ; BAG76696 ; ECSE_1172 .
GeneIDi 6999543.
KEGGi ecy:ECSE_1172.
PATRICi 18420816. VBIEscCol83070_1307.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi AHDIDLS.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci ECOL409438:GHUU-1198-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
    Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
    DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SE11.

Entry informationi

Entry nameiNAGZ_ECOSE
AccessioniPrimary (citable) accession number: B6I9I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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