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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli (strain SE11)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciECOL409438:GHUU-1142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:ECSE_1116
OrganismiEscherichia coli (strain SE11)
Taxonomic identifieri409438 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008199 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei58 – 7821HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei115 – 13521HelicalUniRule annotationAdd
BLAST
Transmembranei146 – 16621HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei224 – 24421HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 27621HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalUniRule annotationAdd
BLAST
Transmembranei319 – 33921HelicalUniRule annotationAdd
BLAST
Transmembranei378 – 39821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Multidrug resistance protein MdtGPRO_1000200780Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB6I9D0.
SMRiB6I9D0. Positions 146-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6I9D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR

RRIPQVSN
Length:408
Mass (Da):43,867
Last modified:December 16, 2008 - v1
Checksum:iC07B719D54A28D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009240 Genomic DNA. Translation: BAG76640.1.
RefSeqiWP_000074172.1. NC_011415.1.

Genome annotation databases

EnsemblBacteriaiBAG76640; BAG76640; ECSE_1116.
KEGGiecy:ECSE_1116.
PATRICi18420706. VBIEscCol83070_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009240 Genomic DNA. Translation: BAG76640.1.
RefSeqiWP_000074172.1. NC_011415.1.

3D structure databases

ProteinModelPortaliB6I9D0.
SMRiB6I9D0. Positions 146-188.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG76640; BAG76640; ECSE_1116.
KEGGiecy:ECSE_1116.
PATRICi18420706. VBIEscCol83070_1252.

Phylogenomic databases

HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.

Enzyme and pathway databases

BioCyciECOL409438:GHUU-1142-MONOMER.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTG_ECOSE
AccessioniPrimary (citable) accession number: B6I9D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.