argH

Functionⁱ

Catalytic activityⁱ

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayⁱ: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

no protein annotated in this organism
Argininosuccinate synthase (argG)
Argininosuccinate lyase (argH)

This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functionⁱ

argininosuccinate lyase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginine biosynthetic process via ornithine Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00114

UniPathwayⁱ

UPA00068; UER00114

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation) Short name: ASALUniRule annotation Alternative name(s): ArginosuccinaseUniRule annotation
Gene namesⁱ	Name:argHUniRule annotation Ordered Locus Names:ECSE_4253
Organismⁱ	Escherichia coli (strain SE11)
Taxonomic identifierⁱ	409438 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000008199 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00006

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000089081	1 – 457	Argininosuccinate lyaseAdd BLAST		457

Proteomic databases

PRIDEⁱ	B6I5H6

PRIDEⁱ

B6I5H6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B6I5H6
SMRⁱ	B6I5H6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000242744
KEGG Orthology (KO) More...KOⁱ	K01755
OMAⁱ	SIMPHKK

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01359 Argininosuccinate_lyase, 1 hit
Gene3Dⁱ	1.10.275.101 hit
HAMAPⁱ	MF_00006 Arg_succ_lyase, 1 hit
InterProⁱ	View protein in InterPro IPR029419 Arg_succ_lyase_C IPR009049 Argininosuccinate_lyase IPR024083 Fumarase/histidase_N IPR020557 Fumarate_lyase_CS IPR000362 Fumarate_lyase_fam IPR022761 Fumarate_lyase_N IPR008948 L-Aspartase-like
PANTHERⁱ	PTHR43814 PTHR43814, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14698 ASL_C2, 1 hit PF00206 Lyase_1, 1 hit
PRINTSⁱ	PR00149 FUMRATELYASE
SUPFAMⁱ	SSF48557 SSF48557, 1 hit
TIGRFAMsⁱ	TIGR00838 argH, 1 hit
PROSITEⁱ	View protein in PROSITE PS00163 FUMARATE_LYASES, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B6I5H6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL 
        60         70         80         90        100
TAEEQAQLEE ALNVLLEDVR ARPQQILESD AEDIHSWVEG KLIDKVGQLG 
       110        120        130        140        150
KKLHTGRSRN DQVATDLKLW CKDTVSELLT ANRQLQSALV ETAQNNQDAV 
       160        170        180        190        200
MPGYTHLQRA QPVTFAHWCL AYVEMLARDE SRLQDALKRL DVSPLGCGAL 
       210        220        230        240        250
AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS AAAIGMVHLS 
       260        270        280        290        300
RFAEDLIFFN TGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ 
       310        320        330        340        350
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MAALVLDGIQ 
       360        370        380        390        400
VKRPRCQEAA QQGYANATEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK 
       410        420        430        440        450
PLEDLPLDEL QKFSPVIDED VYPILSLQSC LDKRAAKGGV SPQQVAQAIA 

FAQARLE

Length:457

Mass (Da):50,387

Last modified:December 16, 2008 - v1

Checksum:ⁱ0270D3D6E01E9717

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP009240 Genomic DNA Translation: BAG79777.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001230081.1, NC_011415.1

Genome annotation databases

EnsemblBacteriaⁱ	BAG79777; BAG79777; ECSE_4253
KEGGⁱ	ecy:ECSE_4253

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B6I5H6	A7ZUH8 B7LA60 B7M714 A0A222QTC5 J7QAW2 E1IVZ3 E9TCZ7 E1JDH8 A0A2A2XJD9 J7QTR7 +17	Escherichia coli O139:H28 (strain E24377A / ETEC) Escherichia coli (strain 55989 / EAEC) Escherichia coli O8 (strain IAI1) Escherichia coli NCCP15648 Escherichia coli Escherichia coli MS 145-7 Escherichia coli MS 117-3 Escherichia coli MS 124-1 Shigella flexneri Escherichia coli chi7122 And more	457	UniRef100_A7ZUH8	Cluster: Argininosuccinate lyase	28

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B6I5H6	Q8ZKL6 A0A0F7JCN4 A0A0D6IRH1 A0A0W3W4G0 E8XL79 A0A0H3NIK8 A0A0F6B9W2 A0A2D3AJ83 A0A0U1IJ51 G5NL10 +1297	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Salmonella enterica I Salmonella typhimurium Salmonella choleraesuis Salmonella typhimurium (strain 4/74) Salmonella typhimurium (strain SL1344) Salmonella typhimurium (strain 14028s / SGSC 2262) Salmonella enteritidis Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 Salmonella enterica subsp. enterica serovar Inverness str. R8-3668 And more	458	UniRef90_Q8ZKL6	Cluster: Argininosuccinate lyase	1,308

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B6I5H6	B8CNI1 A0A2I0DVA2 A8GZ22 UPI000C342640 UPI00048E1882 B0TL84 UPI00065636AA Q7VME5 A0A0H4HS73 UPI0006551240 +2005	Shewanella piezotolerans (strain WP3 / JCM 13877) Shewanella sp. GutDb-MelDb Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) Shewanella Shewanella fidelis Shewanella halifaxensis (strain HAW-EB4) Haemophilus ducreyi Haemophilus ducreyi (strain 35000HP / ATCC 700724) Pseudoalteromonas sp. BSi20652 Pseudoalteromonas sp. BSi20495 And more	461	UniRef50_B8CNI1	Cluster: Argininosuccinate lyase	2,016

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP009240 Genomic DNA Translation: BAG79777.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001230081.1, NC_011415.1

3D structure databases

ProteinModelPortalⁱ	B6I5H6
SMRⁱ	B6I5H6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	B6I5H6

PRIDEⁱ

B6I5H6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAG79777; BAG79777; ECSE_4253
KEGGⁱ	ecy:ECSE_4253

Phylogenomic databases

HOGENOMⁱ	HOG000242744
KEGG Orthology (KO) More...KOⁱ	K01755
OMAⁱ	SIMPHKK

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00114

UniPathwayⁱ

UPA00068; UER00114

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01359 Argininosuccinate_lyase, 1 hit
Gene3Dⁱ	1.10.275.101 hit
HAMAPⁱ	MF_00006 Arg_succ_lyase, 1 hit
InterProⁱ	View protein in InterPro IPR029419 Arg_succ_lyase_C IPR009049 Argininosuccinate_lyase IPR024083 Fumarase/histidase_N IPR020557 Fumarate_lyase_CS IPR000362 Fumarate_lyase_fam IPR022761 Fumarate_lyase_N IPR008948 L-Aspartase-like
PANTHERⁱ	PTHR43814 PTHR43814, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14698 ASL_C2, 1 hit PF00206 Lyase_1, 1 hit
PRINTSⁱ	PR00149 FUMRATELYASE
SUPFAMⁱ	SSF48557 SSF48557, 1 hit
TIGRFAMsⁱ	TIGR00838 argH, 1 hit
PROSITEⁱ	View protein in PROSITE PS00163 FUMARATE_LYASES, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARLY_ECOSE
Accessionⁱ	B6I5H6Primary (citable) accession number: B6I5H6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
	Last sequence update:	December 16, 2008
	Last modified:	October 25, 2017
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B6I5H6 (ARLY_ECOSE)

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Argininosuccinate lyase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: L-arginine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ