B6I581 (EX7L_ECOSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 large subunit
EC=3.1.11.6

Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	ECSE_2795

Organism

Escherichia coli (strain SE11) [Complete proteome] [HAMAP]

Taxonomic identifier

409438 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the XseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378		PRO_1000122059

Sequences

	Sequence		Length	Mass (Da)
	B6I581 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 529E0B0CC0D3105A	FASTA	456	51,844
	10 20 30 40 50 60 MLPSQSPAIF TVSRLNQTVR LLLEHEMGQV WISGEISNFT QPASGHWYFT LKDDTAQVRC 70 80 90 100 110 120 AMFRNSNRRV TFRPQHGQQV LVRANITLYE PRGDYQIIVE SMQPAGEGLL QQKYEQLKAK 130 140 150 160 170 180 LQAEGLFDQQ YKKPLPSPAH CVGVITSKTG AALHDILHVL KRRDPSLPVI IYPTAVQGDD 190 200 210 220 230 240 APGQIVRAIE LANQRNECDV LIVGRGGGSL EDLWSFNDER VARAIFASRI PVVSAVGHET 250 260 270 280 290 300 DVTIADFVAD LRAPTPSAAA EVVSRNQQEL LRQVQSTRQR LEMAMDYYLA NRTRRFTQIH 310 320 330 340 350 360 HRLQQQHPQL RLARQQTMLE RLQKRMSFAL ENQLKRTGQQ QQRLTQRLNQ QNPQPKIHRA 370 380 390 400 410 420 QTRIQQLEYR LAEILRAQLS ATRERFGNAV THLEAVSPLS TLARGYSVTT ATDGNVLKKV 430 440 450 KQVKAGEMLT TRLEDGWIES EVKNIQPVKK SRKKVH

References

[1]

"Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult." Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M. DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SE11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009240 Genomic DNA. Translation: BAG78319.1.
RefSeq	YP_002294070.1. NC_011415.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	409438.ECSE_2795.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAG78319; BAG78319; ECSE_2795.
GeneID	7001180.
KEGG	ecy:ECSE_2795.
PATRIC	18424174. VBIEscCol83070_2964.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1570.
HOGENOM	HOG000229265.
KO	K03601.
OMA	ENAQVRC.
ProtClustDB	PRK00286.
Enzyme and pathway databases
BioCyc	ECOL409438:GHUU-2986-MONOMER.
Family and domain databases
HAMAP	MF_00378. Exonuc_7_L.
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR025824. OB-fold_nuc-bd_dom. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF13742. tRNA_anti_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_ECOSE

Accession

Primary (citable) accession number: B6I581

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program