SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6I1P3

- IF2_ECOSE

UniProt

B6I1P3 - IF2_ECOSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Translation initiation factor IF-2
Gene
infB, ECSE_3454
Organism
Escherichia coli (strain SE11)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi398 – 4058GTP By similarity
Nucleotide bindingi444 – 4485GTP By similarity
Nucleotide bindingi498 – 5014GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL409438:GHUU-3512-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:ECSE_3454
    OrganismiEscherichia coli (strain SE11)
    Taxonomic identifieri409438 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008199: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890Translation initiation factor IF-2UniRule annotation
    PRO_1000093784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei808 – 8081N6-acetyllysine By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiB6I1P3.

    Interactioni

    Protein-protein interaction databases

    STRINGi409438.ECSE_3454.

    Structurei

    3D structure databases

    ProteinModelPortaliB6I1P3.
    SMRiB6I1P3. Positions 2-50, 316-887.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini389 – 558170tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni398 – 4058G1 By similarity
    Regioni423 – 4275G2 By similarity
    Regioni444 – 4474G3 By similarity
    Regioni498 – 5014G4 By similarity
    Regioni534 – 5363G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiDNRTGGY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6I1P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVTIKTLA AERQTSVERL VQQFADAGIR KSADDSVSAQ EKQTLIDHLN    50
    QKNSGPDKLT LQRKTRSTLN IPGTGGKSKS VQIEVRKKRT FVKRDPQEAE 100
    RLAAEEQAQR EAEEQARREA EESAKREAQQ KAEREAAEQA KREAAEQAKR 150
    EAAEKDKVSN QQDDMTKNAQ AEKARREQEA AELKRKAEEE ARRKLEEEAR 200
    RVAEEARRMA EENKWTDNAE PTEDSSDYHV TTSQHARQAE DESDREVEGG 250
    RGRGRNAKAA RPKKGNKHAE SKADREEARA AVRGGKGGKR KGSSLQQGFQ 300
    KPAQAVNRDV VIGETITVGE LANKMAVKGS QVIKAMMKLG AMATINQVID 350
    QETAQLVAEE MGHKVILRRE NELEEAVMSD RDTGAAAEPR APVVTIMGHV 400
    DHGKTSLLDY IRSTKVASGE AGGITQHIGA YHVETENGMI TFLDTPGHAA 450
    FTSMRARGAQ ATDIVVLVVA ADDGVMPQTI EAIQHAKAAQ VPVVVAVNKI 500
    DKPEADPDRV KNELSQYGIL PEEWGGESQF VHVSAKAGTG IDELLDAILL 550
    QAEVLELKAV RKGMASGAVI ESFLDKGRGP VATVLVREGT LHKGDIVLCG 600
    FEYGRVRAMR NELGQEVLEA GPSIPVEILG LSGVPAAGDE VTVVRDEKKA 650
    REVALYRQGK FREVKLARQQ KSKLENMFAN MTEGEVHEVN IVLKADVQGS 700
    VEAISDSLLK LSTDEVKVKI IGSGVGGITE TDATLAAASN AILVGFNVRA 750
    DASARKVIEA ESLDLRYYSV IYNLIDEVKA AMSGMLSPEL KQQIIGLAEV 800
    RDVFKSPKFG AIAGCMVTEG VVKRHNPIRV LRDNVVIYEG ELESLRRFKD 850
    DVNEVRNGME CGIGVKNYND VRTGDVIEVF EIIEIQRTIA 890
    Length:890
    Mass (Da):97,350
    Last modified:December 16, 2008 - v1
    Checksum:i86B9F9B2AE773DDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009240 Genomic DNA. Translation: BAG78978.1.
    RefSeqiYP_002294729.1. NC_011415.1.

    Genome annotation databases

    EnsemblBacteriaiBAG78978; BAG78978; ECSE_3454.
    GeneIDi7001839.
    KEGGiecy:ECSE_3454.
    PATRICi18425522. VBIEscCol83070_3623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009240 Genomic DNA. Translation: BAG78978.1 .
    RefSeqi YP_002294729.1. NC_011415.1.

    3D structure databases

    ProteinModelPortali B6I1P3.
    SMRi B6I1P3. Positions 2-50, 316-887.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 409438.ECSE_3454.

    Proteomic databases

    PRIDEi B6I1P3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG78978 ; BAG78978 ; ECSE_3454 .
    GeneIDi 7001839.
    KEGGi ecy:ECSE_3454.
    PATRICi 18425522. VBIEscCol83070_3623.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi DNRTGGY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci ECOL409438:GHUU-3512-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
      Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
      DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SE11.

    Entry informationi

    Entry nameiIF2_ECOSE
    AccessioniPrimary (citable) accession number: B6I1P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 16, 2008
    Last modified: September 3, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi