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B6I1P3

- IF2_ECOSE

UniProt

B6I1P3 - IF2_ECOSE

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Escherichia coli (strain SE11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi398 – 4058GTPUniRule annotation
    Nucleotide bindingi444 – 4485GTPUniRule annotation
    Nucleotide bindingi498 – 5014GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL409438:GHUU-3512-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:ECSE_3454
    OrganismiEscherichia coli (strain SE11)
    Taxonomic identifieri409438 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008199: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890Translation initiation factor IF-2PRO_1000093784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei808 – 8081N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiB6I1P3.

    Interactioni

    Protein-protein interaction databases

    STRINGi409438.ECSE_3454.

    Structurei

    3D structure databases

    ProteinModelPortaliB6I1P3.
    SMRiB6I1P3. Positions 2-50, 316-887.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini389 – 558170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni398 – 4058G1By similarity
    Regioni423 – 4275G2By similarity
    Regioni444 – 4474G3By similarity
    Regioni498 – 5014G4By similarity
    Regioni534 – 5363G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiDNRTGGY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6I1P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVTIKTLA AERQTSVERL VQQFADAGIR KSADDSVSAQ EKQTLIDHLN    50
    QKNSGPDKLT LQRKTRSTLN IPGTGGKSKS VQIEVRKKRT FVKRDPQEAE 100
    RLAAEEQAQR EAEEQARREA EESAKREAQQ KAEREAAEQA KREAAEQAKR 150
    EAAEKDKVSN QQDDMTKNAQ AEKARREQEA AELKRKAEEE ARRKLEEEAR 200
    RVAEEARRMA EENKWTDNAE PTEDSSDYHV TTSQHARQAE DESDREVEGG 250
    RGRGRNAKAA RPKKGNKHAE SKADREEARA AVRGGKGGKR KGSSLQQGFQ 300
    KPAQAVNRDV VIGETITVGE LANKMAVKGS QVIKAMMKLG AMATINQVID 350
    QETAQLVAEE MGHKVILRRE NELEEAVMSD RDTGAAAEPR APVVTIMGHV 400
    DHGKTSLLDY IRSTKVASGE AGGITQHIGA YHVETENGMI TFLDTPGHAA 450
    FTSMRARGAQ ATDIVVLVVA ADDGVMPQTI EAIQHAKAAQ VPVVVAVNKI 500
    DKPEADPDRV KNELSQYGIL PEEWGGESQF VHVSAKAGTG IDELLDAILL 550
    QAEVLELKAV RKGMASGAVI ESFLDKGRGP VATVLVREGT LHKGDIVLCG 600
    FEYGRVRAMR NELGQEVLEA GPSIPVEILG LSGVPAAGDE VTVVRDEKKA 650
    REVALYRQGK FREVKLARQQ KSKLENMFAN MTEGEVHEVN IVLKADVQGS 700
    VEAISDSLLK LSTDEVKVKI IGSGVGGITE TDATLAAASN AILVGFNVRA 750
    DASARKVIEA ESLDLRYYSV IYNLIDEVKA AMSGMLSPEL KQQIIGLAEV 800
    RDVFKSPKFG AIAGCMVTEG VVKRHNPIRV LRDNVVIYEG ELESLRRFKD 850
    DVNEVRNGME CGIGVKNYND VRTGDVIEVF EIIEIQRTIA 890
    Length:890
    Mass (Da):97,350
    Last modified:December 16, 2008 - v1
    Checksum:i86B9F9B2AE773DDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009240 Genomic DNA. Translation: BAG78978.1.
    RefSeqiYP_002294729.1. NC_011415.1.

    Genome annotation databases

    EnsemblBacteriaiBAG78978; BAG78978; ECSE_3454.
    GeneIDi7001839.
    KEGGiecy:ECSE_3454.
    PATRICi18425522. VBIEscCol83070_3623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009240 Genomic DNA. Translation: BAG78978.1 .
    RefSeqi YP_002294729.1. NC_011415.1.

    3D structure databases

    ProteinModelPortali B6I1P3.
    SMRi B6I1P3. Positions 2-50, 316-887.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 409438.ECSE_3454.

    Proteomic databases

    PRIDEi B6I1P3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG78978 ; BAG78978 ; ECSE_3454 .
    GeneIDi 7001839.
    KEGGi ecy:ECSE_3454.
    PATRICi 18425522. VBIEscCol83070_3623.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi DNRTGGY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci ECOL409438:GHUU-3512-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
      Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
      DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SE11.

    Entry informationi

    Entry nameiIF2_ECOSE
    AccessioniPrimary (citable) accession number: B6I1P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3