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B6I1P3

- IF2_ECOSE

UniProt

B6I1P3 - IF2_ECOSE

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Escherichia coli (strain SE11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi398 – 4058GTPUniRule annotation
Nucleotide bindingi444 – 4485GTPUniRule annotation
Nucleotide bindingi498 – 5014GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL409438:GHUU-3512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:ECSE_3454
OrganismiEscherichia coli (strain SE11)
Taxonomic identifieri409438 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008199: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Translation initiation factor IF-2PRO_1000093784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei808 – 8081N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiB6I1P3.

Interactioni

Protein-protein interaction databases

STRINGi409438.ECSE_3454.

Structurei

3D structure databases

ProteinModelPortaliB6I1P3.
SMRiB6I1P3. Positions 2-50, 316-887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini389 – 558170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni398 – 4058G1By similarity
Regioni423 – 4275G2By similarity
Regioni444 – 4474G3By similarity
Regioni498 – 5014G4By similarity
Regioni534 – 5363G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6I1P3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVTIKTLA AERQTSVERL VQQFADAGIR KSADDSVSAQ EKQTLIDHLN
60 70 80 90 100
QKNSGPDKLT LQRKTRSTLN IPGTGGKSKS VQIEVRKKRT FVKRDPQEAE
110 120 130 140 150
RLAAEEQAQR EAEEQARREA EESAKREAQQ KAEREAAEQA KREAAEQAKR
160 170 180 190 200
EAAEKDKVSN QQDDMTKNAQ AEKARREQEA AELKRKAEEE ARRKLEEEAR
210 220 230 240 250
RVAEEARRMA EENKWTDNAE PTEDSSDYHV TTSQHARQAE DESDREVEGG
260 270 280 290 300
RGRGRNAKAA RPKKGNKHAE SKADREEARA AVRGGKGGKR KGSSLQQGFQ
310 320 330 340 350
KPAQAVNRDV VIGETITVGE LANKMAVKGS QVIKAMMKLG AMATINQVID
360 370 380 390 400
QETAQLVAEE MGHKVILRRE NELEEAVMSD RDTGAAAEPR APVVTIMGHV
410 420 430 440 450
DHGKTSLLDY IRSTKVASGE AGGITQHIGA YHVETENGMI TFLDTPGHAA
460 470 480 490 500
FTSMRARGAQ ATDIVVLVVA ADDGVMPQTI EAIQHAKAAQ VPVVVAVNKI
510 520 530 540 550
DKPEADPDRV KNELSQYGIL PEEWGGESQF VHVSAKAGTG IDELLDAILL
560 570 580 590 600
QAEVLELKAV RKGMASGAVI ESFLDKGRGP VATVLVREGT LHKGDIVLCG
610 620 630 640 650
FEYGRVRAMR NELGQEVLEA GPSIPVEILG LSGVPAAGDE VTVVRDEKKA
660 670 680 690 700
REVALYRQGK FREVKLARQQ KSKLENMFAN MTEGEVHEVN IVLKADVQGS
710 720 730 740 750
VEAISDSLLK LSTDEVKVKI IGSGVGGITE TDATLAAASN AILVGFNVRA
760 770 780 790 800
DASARKVIEA ESLDLRYYSV IYNLIDEVKA AMSGMLSPEL KQQIIGLAEV
810 820 830 840 850
RDVFKSPKFG AIAGCMVTEG VVKRHNPIRV LRDNVVIYEG ELESLRRFKD
860 870 880 890
DVNEVRNGME CGIGVKNYND VRTGDVIEVF EIIEIQRTIA
Length:890
Mass (Da):97,350
Last modified:December 16, 2008 - v1
Checksum:i86B9F9B2AE773DDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG78978.1.
RefSeqiYP_002294729.1. NC_011415.1.

Genome annotation databases

EnsemblBacteriaiBAG78978; BAG78978; ECSE_3454.
GeneIDi7001839.
KEGGiecy:ECSE_3454.
PATRICi18425522. VBIEscCol83070_3623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG78978.1 .
RefSeqi YP_002294729.1. NC_011415.1.

3D structure databases

ProteinModelPortali B6I1P3.
SMRi B6I1P3. Positions 2-50, 316-887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 409438.ECSE_3454.

Proteomic databases

PRIDEi B6I1P3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG78978 ; BAG78978 ; ECSE_3454 .
GeneIDi 7001839.
KEGGi ecy:ECSE_3454.
PATRICi 18425522. VBIEscCol83070_3623.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi DNRTGGY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci ECOL409438:GHUU-3512-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
    Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
    DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SE11.

Entry informationi

Entry nameiIF2_ECOSE
AccessioniPrimary (citable) accession number: B6I1P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3