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B6I074

- BETA_ECOSE

UniProt

B6I074 - BETA_ECOSE

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Escherichia coli (strain SE11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciECOL409438:GHUU-340-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:ECSE_0332
OrganismiEscherichia coli (strain SE11)
Taxonomic identifieri409438 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008199: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Oxygen-dependent choline dehydrogenasePRO_1000133331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi409438.ECSE_0332.

Structurei

3D structure databases

ProteinModelPortaliB6I074.
SMRiB6I074. Positions 1-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6I074-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFDYIIIGA GSAGNVLATR LTEDPNTSVL LLEAGGPDYR FDFRTQMPAA
60 70 80 90 100
LAFPLQGKRY NWAYETEPEP FMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
ALDLDNWAQE PGLENWSYLD CLPYYRKAET RDVGENDYHG GDGPVSVTTS
160 170 180 190 200
KPGVNPLFEA MIEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPQGRRAST
210 220 230 240 250
ARGYLDQAKS RPNLTIRTHA MTDHIIFDGK RAVGVEWLEG DSTIPTRATA
260 270 280 290 300
NKEVLLCAGA IASPQILQRS GVGNAELLAE FDIPLVHELP GVGENLQDHL
310 320 330 340 350
EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGVGAS NHFEAGGFIR
360 370 380 390 400
SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRIK
410 420 430 440 450
SRDPHQHPAI LFNYMSHEQD WQEFRDAIRI TREIMHQPAL DQYRGREISP
460 470 480 490 500
GTECQTDEQL DEFVRNHAET AFHPCGTCKM GYDEMSVVDG EGRVHGLEGL
510 520 530 540 550
RVVDASIMPQ IITGNLNATT IMIGEKIADM IRGQEALPRS TAGYFVANGM

PVRAKK
Length:556
Mass (Da):61,848
Last modified:December 16, 2008 - v1
Checksum:iAE97955D134D9ECE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG75856.1.
RefSeqiYP_002291607.1. NC_011415.1.

Genome annotation databases

EnsemblBacteriaiBAG75856; BAG75856; ECSE_0332.
GeneIDi6998703.
KEGGiecy:ECSE_0332.
PATRICi18419071. VBIEscCol83070_0454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009240 Genomic DNA. Translation: BAG75856.1 .
RefSeqi YP_002291607.1. NC_011415.1.

3D structure databases

ProteinModelPortali B6I074.
SMRi B6I074. Positions 1-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 409438.ECSE_0332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG75856 ; BAG75856 ; ECSE_0332 .
GeneIDi 6998703.
KEGGi ecy:ECSE_0332.
PATRICi 18419071. VBIEscCol83070_0454.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci ECOL409438:GHUU-340-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
    Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
    DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SE11.

Entry informationi

Entry nameiBETA_ECOSE
AccessioniPrimary (citable) accession number: B6I074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3