B6HRL5 (MTLD_PENCW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17

Gene names

ORF Names:

Pc22g20800

Organism

Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]

Taxonomic identifier

500485 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium › Penicillium chrysogenum complex

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371532
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity
Sites
	Active site	213	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6HRL5 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: DF07664EA8DAFF7B	FASTA	388	42,445
	10 20 30 40 50 60 MEKKAVHFGG GNIGRGFVAE FLHTAGYEVV FVDVMDSIIT ALQNTKSYEV TEVSDEGEAT 70 80 90 100 110 120 KTITNYRAIN SKTHESDVIN EISTATVVTC AVGPNILKFI APAIAKGIDA RTAATPLAVI 130 140 150 160 170 180 ACENAIGATD TLHHFIKDNT AQDRLGSMPD RARFANSAID RIVPGQAADS GLNVRIEKFY 190 200 210 220 230 240 EWAVESTPFG EFGHPDIPAI HWVSDLEPYI ERKLFTVNTG HATAAYYGYN AGKKTIAEAL 250 260 270 280 290 300 HDSRIRGIVR DVLQETASLI IDKHEISAAE QQEYVETIIT RISNPYLEDT VERVGRAPMR 310 320 330 340 350 360 KVSRKERFIG PASQLAERGG KFQSLLGSLE MALRFQNVEG DEESVELAKI LKENAPADAA 370 380 VRLTGLDRDH PLFPHVVKVV DGVQSDAK

References

[1]

"Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum." van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M., Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M., Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F., Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A. , van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R., Bovenberg R.A.L. Nat. Biotechnol. 26:1161-1168(2008) [PubMed: 18820685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM920437 Genomic DNA. Translation: CAP99368.1.
RefSeq	XP_002565979.1. XM_002565933.1.
3D structure databases
ProteinModelPortal	B6HRL5.
ModBase	Search...
Protein-protein interaction databases
STRING	B6HRL5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8305222.
KEGG	pcs:Pc22g20800.
Phylogenomic databases
OrthoDB	EOG469V3C.
Enzyme and pathway databases
BioCyc	PCHR:PC22G20800-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PENCW

Accession

Primary (citable) accession number: B6HRL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	December 16, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program