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B6HPP6

- CBPYA_PENCW

UniProt

B6HPP6 - CBPYA_PENCW

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Protein
Carboxypeptidase Y homolog A
Gene
cpyA, Pc22g00890
Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei273 – 2731 By similarity
Active sitei465 – 4651 By similarity
Active sitei527 – 5271 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciPCHR:PC22G00890-MONOMER.

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:Pc22g00890
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c22

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 131114 By similarity
PRO_0000407467Add
BLAST
Chaini132 – 550419Carboxypeptidase Y homolog A
PRO_5000410069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi186 ↔ 426 By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi320 ↔ 334 By similarity
Disulfide bondi344 ↔ 367 By similarity
Disulfide bondi351 ↔ 360 By similarity
Disulfide bondi389 ↔ 396 By similarity
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi500485.B6HPP6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiWPGQKEY.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6HPP6-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLSATLLA GAASAAAPPF QQVLGAHKEY AENVIQQGAD AFKPLQHLQD    50
QFKSLSGEAR QLWEEVSNYF PESMESAPLL SLPKKHTRRP DSHWDYHVSG 100
AEVQDIWVSG AEGTKEREVD GRLEAYNLRA KKVDPSALGI DPGVKQYSGY 150
LDDDENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFMELGPSS 200
IDSKIKPVYN DFSWNNNASV IFLDQPINVG YSYSGGSVSD TVAAGKDVYA 250
LLTLFFKQFP EYATQDFHIA GESYAGHYIP VMASEILSHK KRNINLKSVL 300
IGNGLTDGLT QYGYYRPMAC GEGGYPAVLD ESTCQSMDNS LSRCQSMIQA 350
CYNSESPWVC VPASIYCNNA MLGPYQRTGQ NVYDIRGKCE DESNLCYKGM 400
GYVSEYLGQE SVREAVGAEV DGYDSCNFDI NRNFLFNGDW FKPYHRLVPG 450
LLEQIPVLIY AGDADFICNW LGNKAWSEAL EWPGQKEFAS AELEDLKIVQ 500
NEHVGKKIGQ IKSHGNFTFM RIYGGGHMVP MDQPESGLEF FNRWIGGEWF 550
Length:550
Mass (Da):61,428
Last modified:December 16, 2008 - v1
Checksum:i8542765BCFB51BE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920437 Genomic DNA. Translation: CAP97377.1.
RefSeqiXP_002564134.1. XM_002564088.1.

Genome annotation databases

GeneIDi8306581.
KEGGipcs:Pc22g00890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920437 Genomic DNA. Translation: CAP97377.1 .
RefSeqi XP_002564134.1. XM_002564088.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6HPP6.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8306581.
KEGGi pcs:Pc22g00890.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000198296.
KOi K13289.
OMAi WPGQKEY.
OrthoDBi EOG7XDBR1.

Enzyme and pathway databases

BioCyci PCHR:PC22G00890-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiCBPYA_PENCW
AccessioniPrimary (citable) accession number: B6HPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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