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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei273 – 2731PROSITE-ProRule annotation
Active sitei465 – 4651PROSITE-ProRule annotation
Active sitei527 – 5271PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciPCHR:PC22G00890-MONOMER.

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:Pc22g00890
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c22

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 131114By similarityPRO_0000407467Add
BLAST
Chaini132 – 550419Carboxypeptidase Y homolog APRO_5000410069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi186 ↔ 426By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi320 ↔ 334By similarity
Disulfide bondi344 ↔ 367By similarity
Disulfide bondi351 ↔ 360By similarity
Disulfide bondi389 ↔ 396By similarity
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi500485.B6HPP6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiNTESSWI.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6HPP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLSATLLA GAASAAAPPF QQVLGAHKEY AENVIQQGAD AFKPLQHLQD
60 70 80 90 100
QFKSLSGEAR QLWEEVSNYF PESMESAPLL SLPKKHTRRP DSHWDYHVSG
110 120 130 140 150
AEVQDIWVSG AEGTKEREVD GRLEAYNLRA KKVDPSALGI DPGVKQYSGY
160 170 180 190 200
LDDDENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFMELGPSS
210 220 230 240 250
IDSKIKPVYN DFSWNNNASV IFLDQPINVG YSYSGGSVSD TVAAGKDVYA
260 270 280 290 300
LLTLFFKQFP EYATQDFHIA GESYAGHYIP VMASEILSHK KRNINLKSVL
310 320 330 340 350
IGNGLTDGLT QYGYYRPMAC GEGGYPAVLD ESTCQSMDNS LSRCQSMIQA
360 370 380 390 400
CYNSESPWVC VPASIYCNNA MLGPYQRTGQ NVYDIRGKCE DESNLCYKGM
410 420 430 440 450
GYVSEYLGQE SVREAVGAEV DGYDSCNFDI NRNFLFNGDW FKPYHRLVPG
460 470 480 490 500
LLEQIPVLIY AGDADFICNW LGNKAWSEAL EWPGQKEFAS AELEDLKIVQ
510 520 530 540 550
NEHVGKKIGQ IKSHGNFTFM RIYGGGHMVP MDQPESGLEF FNRWIGGEWF
Length:550
Mass (Da):61,428
Last modified:December 16, 2008 - v1
Checksum:i8542765BCFB51BE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920437 Genomic DNA. Translation: CAP97377.1.
RefSeqiXP_002564134.1. XM_002564088.1.

Genome annotation databases

GeneIDi8306581.
KEGGipcs:Pc22g00890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920437 Genomic DNA. Translation: CAP97377.1.
RefSeqiXP_002564134.1. XM_002564088.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.B6HPP6.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8306581.
KEGGipcs:Pc22g00890.

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiNTESSWI.
OrthoDBiEOG7XDBR1.

Enzyme and pathway databases

BioCyciPCHR:PC22G00890-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiCBPYA_PENCW
AccessioniPrimary (citable) accession number: B6HPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.