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B6HPP6

- CBPYA_PENCW

UniProt

B6HPP6 - CBPYA_PENCW

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei273 – 2731PROSITE-ProRule annotation
    Active sitei465 – 4651PROSITE-ProRule annotation
    Active sitei527 – 5271PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciPCHR:PC22G00890-MONOMER.

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:Pc22g00890
    OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
    Taxonomic identifieri500485 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
    ProteomesiUP000000724: Contig Pc00c22

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 131114By similarityPRO_0000407467Add
    BLAST
    Chaini132 – 550419Carboxypeptidase Y homolog APRO_5000410069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi186 ↔ 426By similarity
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 334By similarity
    Disulfide bondi344 ↔ 367By similarity
    Disulfide bondi351 ↔ 360By similarity
    Disulfide bondi389 ↔ 396By similarity
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi500485.B6HPP6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    KOiK13289.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6HPP6-1 [UniParc]FASTAAdd to Basket

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    MRVLSATLLA GAASAAAPPF QQVLGAHKEY AENVIQQGAD AFKPLQHLQD    50
    QFKSLSGEAR QLWEEVSNYF PESMESAPLL SLPKKHTRRP DSHWDYHVSG 100
    AEVQDIWVSG AEGTKEREVD GRLEAYNLRA KKVDPSALGI DPGVKQYSGY 150
    LDDDENDKHL FYWFFESRND PKNDPVVLWL NGGPGCSSLT GLFMELGPSS 200
    IDSKIKPVYN DFSWNNNASV IFLDQPINVG YSYSGGSVSD TVAAGKDVYA 250
    LLTLFFKQFP EYATQDFHIA GESYAGHYIP VMASEILSHK KRNINLKSVL 300
    IGNGLTDGLT QYGYYRPMAC GEGGYPAVLD ESTCQSMDNS LSRCQSMIQA 350
    CYNSESPWVC VPASIYCNNA MLGPYQRTGQ NVYDIRGKCE DESNLCYKGM 400
    GYVSEYLGQE SVREAVGAEV DGYDSCNFDI NRNFLFNGDW FKPYHRLVPG 450
    LLEQIPVLIY AGDADFICNW LGNKAWSEAL EWPGQKEFAS AELEDLKIVQ 500
    NEHVGKKIGQ IKSHGNFTFM RIYGGGHMVP MDQPESGLEF FNRWIGGEWF 550
    Length:550
    Mass (Da):61,428
    Last modified:December 16, 2008 - v1
    Checksum:i8542765BCFB51BE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920437 Genomic DNA. Translation: CAP97377.1.
    RefSeqiXP_002564134.1. XM_002564088.1.

    Genome annotation databases

    GeneIDi8306581.
    KEGGipcs:Pc22g00890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920437 Genomic DNA. Translation: CAP97377.1 .
    RefSeqi XP_002564134.1. XM_002564088.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 500485.B6HPP6.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8306581.
    KEGGi pcs:Pc22g00890.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    KOi K13289.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Enzyme and pathway databases

    BioCyci PCHR:PC22G00890-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

    Entry informationi

    Entry nameiCBPYA_PENCW
    AccessioniPrimary (citable) accession number: B6HPP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3