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B6HPP6 (CBPYA_PENCW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 131114 By similarity
PRO_0000407467
Chain132 – 550419Carboxypeptidase Y homolog A
PRO_5000410069

Sites

Active site2731 By similarity
Active site4651 By similarity
Active site5271 By similarity

Amino acid modifications

Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential
Disulfide bond186 ↔ 426 By similarity
Disulfide bond320 ↔ 334 By similarity
Disulfide bond344 ↔ 367 By similarity
Disulfide bond351 ↔ 360 By similarity
Disulfide bond389 ↔ 396 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6HPP6 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: 8542765BCFB51BE1

FASTA55061,428
        10         20         30         40         50         60 
MRVLSATLLA GAASAAAPPF QQVLGAHKEY AENVIQQGAD AFKPLQHLQD QFKSLSGEAR 

        70         80         90        100        110        120 
QLWEEVSNYF PESMESAPLL SLPKKHTRRP DSHWDYHVSG AEVQDIWVSG AEGTKEREVD 

       130        140        150        160        170        180 
GRLEAYNLRA KKVDPSALGI DPGVKQYSGY LDDDENDKHL FYWFFESRND PKNDPVVLWL 

       190        200        210        220        230        240 
NGGPGCSSLT GLFMELGPSS IDSKIKPVYN DFSWNNNASV IFLDQPINVG YSYSGGSVSD 

       250        260        270        280        290        300 
TVAAGKDVYA LLTLFFKQFP EYATQDFHIA GESYAGHYIP VMASEILSHK KRNINLKSVL 

       310        320        330        340        350        360 
IGNGLTDGLT QYGYYRPMAC GEGGYPAVLD ESTCQSMDNS LSRCQSMIQA CYNSESPWVC 

       370        380        390        400        410        420 
VPASIYCNNA MLGPYQRTGQ NVYDIRGKCE DESNLCYKGM GYVSEYLGQE SVREAVGAEV 

       430        440        450        460        470        480 
DGYDSCNFDI NRNFLFNGDW FKPYHRLVPG LLEQIPVLIY AGDADFICNW LGNKAWSEAL 

       490        500        510        520        530        540 
EWPGQKEFAS AELEDLKIVQ NEHVGKKIGQ IKSHGNFTFM RIYGGGHMVP MDQPESGLEF 

       550 
FNRWIGGEWF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM920437 Genomic DNA. Translation: CAP97377.1.
RefSeqXP_002564134.1. XM_002564088.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING500485.B6HPP6.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8306581.
KEGGpcs:Pc22g00890.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000198296.
KOK13289.
OMAHYRPMAC.
OrthoDBEOG7XDBR1.

Enzyme and pathway databases

BioCycPCHR:PC22G00890-MONOMER.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_PENCW
AccessionPrimary (citable) accession number: B6HPP6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries