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Protein

DNA ligase

Gene

Pc21g07170

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCHR:PC21G07170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Pc21g07170Imported, PCH_Pc21g07170Imported
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)Imported
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c21

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002567758.1.

Structurei

3D structure databases

ProteinModelPortaliB6HK40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini423 – 548126DNA_LIGASE_A3InterPro annotationAdd
BLAST
Domaini713 – 79886BRCTInterPro annotationAdd
BLAST
Domaini875 – 988114BRCTInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0966. Eukaryota.
COG1793. LUCA.
KOiK10777.
OMAiHPYEEAT.
OrthoDBiEOG092C18KW.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 2 hits.
PfamiPF16589. BRCT_2. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6HK40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDEILGQD DVLKPEQEED LDEKYPNRPH NRAPTLPFHD LYLDLFNPLS
60 70 80 90 100
ELKKKPSGPA PARRKAGPHG KGATSLNPFE RRRDVIERFI SRWRKDVGDD
110 120 130 140 150
IYPALRLILP DKDRDRPMYG IKEKAIGRML VKIMKINKES EDGYNLLNWK
160 170 180 190 200
LPGQGATTRM AGDFARRCFD VLSKRPMRTD PGDMTIEEVN EKLDKLSAAS
210 220 230 240 250
KEDEQLPILT EFYRRMNPEE LLWLIRIILR QMKVGATERT FFDVWHPDAE
260 270 280 290 300
NLYSISSSLR RVCWELHDPN IRLEGEERGI ALMQCFQPQL AQFQMHSFER
310 320 330 340 350
IIARMKPTED DNVFWIEEKM DGERMQLHMA PDDSTKGGRK FGFWSRKAKE
360 370 380 390 400
YTYLYGNGIY DENGALTRHL KDAFVDGVQS IILDGEMITW DPEQDAMVPF
410 420 430 440 450
GTLKTAALAE QRNPFSNGPR PLFRVFDILH LNGRDLTKYT LRDRRNALEK
460 470 480 490 500
TVRPVHRRFE IHSYEEATTT TEVEAALRKV VAEASEGLVL KNPRSPYRLN
510 520 530 540 550
ERHDDWMKVK PDYMTEFGES LDVIVIGGYY GSGRRGGALS SFLCGLRVDD
560 570 580 590 600
STQAAEKCWS FCKVGGGFTA ADYQEVRHHT DGKWKAWDAK KPPTTFVELA
610 620 630 640 650
GGDAQHERPD MWIKPSDSIV LCVKAASVAI SDQFRMGLAL RFPRFKKLRK
660 670 680 690 700
DKDWKTALSV QEFLDLKSNA EQEHREKEFS VDNSRKKRVK RATKKPLTVA
710 720 730 740 750
GHEDNVDVQY LGPSGHVFDE LNFFIMTEST VPEKKTKLQL EQLVKANGGK
760 770 780 790 800
IYQTKTAAVD TLCVAERRTV KVASLQKSGE QNIIRPSWLI DCVKQNEIDA
810 820 830 840 850
GLPDLLLPFE PRHMFFMTEE KEEEVAANVD KFMDSYARDT TVNELKDADD
860 870 880 890 900
VPDPETTQRI ETRIQERVNA GYTVPVGWLF RGLKFHFYSN GNQPDESASR
910 920 930 940 950
EIRREDQRLQ FARNTARFAA AEIAKTLKSS GITHVIVDPE TVSSADKTSL
960 970 980 990
RNTLAAKPGA KMPHLVSVGW VEECWKNGTL LDEERFPILR
Length:990
Mass (Da):113,516
Last modified:December 16, 2008 - v1
Checksum:i4ED51FADC197051E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920436 Genomic DNA. Translation: CAP95614.1.
RefSeqiXP_002567758.1. XM_002567712.1.

Genome annotation databases

EnsemblFungiiCAP95614; CAP95614; PCH_Pc21g07170.
GeneIDi8314155.
KEGGipcs:Pc21g07170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920436 Genomic DNA. Translation: CAP95614.1.
RefSeqiXP_002567758.1. XM_002567712.1.

3D structure databases

ProteinModelPortaliB6HK40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002567758.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP95614; CAP95614; PCH_Pc21g07170.
GeneIDi8314155.
KEGGipcs:Pc21g07170.

Phylogenomic databases

eggNOGiKOG0966. Eukaryota.
COG1793. LUCA.
KOiK10777.
OMAiHPYEEAT.
OrthoDBiEOG092C18KW.

Enzyme and pathway databases

BioCyciPCHR:PC21G07170-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 2 hits.
PfamiPF16589. BRCT_2. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB6HK40_PENRW
AccessioniPrimary (citable) accession number: B6HK40
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.