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Protein

DNA ligase

Gene

Pc21g07170

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCHR:PC21G07170-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Pc21g07170Imported, PCH_Pc21g07170Imported
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)Imported
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum species complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002567758.1

Structurei

3D structure databases

ProteinModelPortaliB6HK40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini423 – 548DNA_LIGASE_A3InterPro annotationAdd BLAST126
Domaini713 – 798BRCTInterPro annotationAdd BLAST86
Domaini875 – 988BRCTInterPro annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 206Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0966 Eukaryota
COG1793 LUCA
KOiK10777
OMAiHMCPSTK
OrthoDBiEOG092C18KW

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR029710 LIG4
IPR012340 NA-bd_OB-fold
PANTHERiPTHR10459:SF7 PTHR10459:SF7, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 2 hits
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B6HK40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDEILGQD DVLKPEQEED LDEKYPNRPH NRAPTLPFHD LYLDLFNPLS
60 70 80 90 100
ELKKKPSGPA PARRKAGPHG KGATSLNPFE RRRDVIERFI SRWRKDVGDD
110 120 130 140 150
IYPALRLILP DKDRDRPMYG IKEKAIGRML VKIMKINKES EDGYNLLNWK
160 170 180 190 200
LPGQGATTRM AGDFARRCFD VLSKRPMRTD PGDMTIEEVN EKLDKLSAAS
210 220 230 240 250
KEDEQLPILT EFYRRMNPEE LLWLIRIILR QMKVGATERT FFDVWHPDAE
260 270 280 290 300
NLYSISSSLR RVCWELHDPN IRLEGEERGI ALMQCFQPQL AQFQMHSFER
310 320 330 340 350
IIARMKPTED DNVFWIEEKM DGERMQLHMA PDDSTKGGRK FGFWSRKAKE
360 370 380 390 400
YTYLYGNGIY DENGALTRHL KDAFVDGVQS IILDGEMITW DPEQDAMVPF
410 420 430 440 450
GTLKTAALAE QRNPFSNGPR PLFRVFDILH LNGRDLTKYT LRDRRNALEK
460 470 480 490 500
TVRPVHRRFE IHSYEEATTT TEVEAALRKV VAEASEGLVL KNPRSPYRLN
510 520 530 540 550
ERHDDWMKVK PDYMTEFGES LDVIVIGGYY GSGRRGGALS SFLCGLRVDD
560 570 580 590 600
STQAAEKCWS FCKVGGGFTA ADYQEVRHHT DGKWKAWDAK KPPTTFVELA
610 620 630 640 650
GGDAQHERPD MWIKPSDSIV LCVKAASVAI SDQFRMGLAL RFPRFKKLRK
660 670 680 690 700
DKDWKTALSV QEFLDLKSNA EQEHREKEFS VDNSRKKRVK RATKKPLTVA
710 720 730 740 750
GHEDNVDVQY LGPSGHVFDE LNFFIMTEST VPEKKTKLQL EQLVKANGGK
760 770 780 790 800
IYQTKTAAVD TLCVAERRTV KVASLQKSGE QNIIRPSWLI DCVKQNEIDA
810 820 830 840 850
GLPDLLLPFE PRHMFFMTEE KEEEVAANVD KFMDSYARDT TVNELKDADD
860 870 880 890 900
VPDPETTQRI ETRIQERVNA GYTVPVGWLF RGLKFHFYSN GNQPDESASR
910 920 930 940 950
EIRREDQRLQ FARNTARFAA AEIAKTLKSS GITHVIVDPE TVSSADKTSL
960 970 980 990
RNTLAAKPGA KMPHLVSVGW VEECWKNGTL LDEERFPILR
Length:990
Mass (Da):113,516
Last modified:December 16, 2008 - v1
Checksum:i4ED51FADC197051E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920436 Genomic DNA Translation: CAP95614.1
RefSeqiXP_002567758.1, XM_002567712.1

Genome annotation databases

EnsemblFungiiCAP95614; CAP95614; PCH_Pc21g07170
GeneIDi8314155
KEGGipcs:Pc21g07170

Similar proteinsi

Entry informationi

Entry nameiB6HK40_PENRW
AccessioniPrimary (citable) accession number: B6HK40
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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