B6HIM5 (CYNS_PENCW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyanate hydratase
Short name=Cyanase
EC=4.2.1.104

Alternative name(s):
Cyanate hydrolase
Cyanate lyase

Gene names

Name:	cyn1
ORF Names:	Pc21g18920

Organism

Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]

Taxonomic identifier

500485 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium › Penicillium chrysogenum complex › Penicillium chrysogenum

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide By similarity. HAMAP-Rule MF_03139
Catalytic activity	Cyanate + HCO3- + 2 H+ = NH3 + 2 CO2. HAMAP-Rule MF_03139
Sequence similarities	Belongs to the cyanase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cyanate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro cyanate hydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Cyanate hydratase HAMAP-Rule MF_03139		PRO_0000403261
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Active site	126	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6HIM5 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: A319EB27E5992390	FASTA	160	18,075
	10 20 30 40 50 60 MSLATLDTTE HPNLPTVSTT LFKAKAARKL SFEKIGEHIG RNEVAAAAIF YGQAKPSRED 70 80 90 100 110 120 IEKLADLLHI PQQPLEEQLN GFPDRGRSVE MPPKEPLIYR LYEIVQNYGY AYKAVLNEKF 130 140 150 160 GDGIMSAISF STKVEKETDE DGNNWAVITL RGKWLPFSRF

References

[1]

"Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum." van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M., Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M., Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F., Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A. , van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R., Bovenberg R.A.L. Nat. Biotechnol. 26:1161-1168(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM920436 Genomic DNA. Translation: CAP96789.1.
RefSeq	XP_002568883.1. XM_002568837.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	500485.B6HIM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8317219.
KEGG	pcs:Pc21g18920.
Phylogenomic databases
eggNOG	COG1513.
KO	K01725.
OrthoDB	EOG4MGWHS.
Enzyme and pathway databases
BioCyc	PCHR:PC21G18920-MONOMER.
Family and domain databases
Gene3D	1.10.260.40. 1 hit. 3.30.1160.10. 1 hit.
HAMAP	MF_00535. Cyanate_hydrat.
InterPro	IPR008076. Cyanase. IPR003712. Cyanate_lyase_C. IPR010982. Lambda_DNA-bd_dom. [Graphical view]
Pfam	PF02560. Cyanate_lyase. 1 hit. [Graphical view]
PIRSF	PIRSF001263. Cyanate_hydratas. 1 hit.
PRINTS	PR01693. CYANASE.
SUPFAM	SSF55234. Cyanate_lyase_C. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
TIGRFAMs	TIGR00673. cynS. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYNS_PENCW

Accession

Primary (citable) accession number: B6HIM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	December 16, 2008
Last modified:	May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program