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B6HFS8

- DAPB_PENCW

UniProt

B6HFS8 - DAPB_PENCW

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, Pc20g06070
Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay system By similarity
Active sitei831 – 8311Charge relay system By similarity
Active sitei864 – 8641Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciPCHR:PC20G06070-MONOMER.

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:Pc20g06070
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c20

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini112 – 903792Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Probable dipeptidyl-aminopeptidase B
PRO_0000412156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi808 – 8081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.B6HFS8.

Structurei

3D structure databases

ProteinModelPortaliB6HFS8.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01282.
OMAiMALMTMF.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B6HFS8-1 [UniParc]FASTAAdd to Basket

« Hide

MGKFEDDGNS ESVPLTRQRS ESLASQTSTD SGLSIASESF MKNHKGGNTM    50
PTDGGDGDRY LDVEDGGETG LDEPLISSGT KTGSSSRLRK IVWLLVLLCV 100
GGWVLSFVLF LTQKRPDTAA LSSASTVEIH EPGPATGGTS HGKPVTLEQV 150
LSGTWSPKSH AISWIAGPDG EDGLLVEQGE KQDAFLRVKD IRSSEDGVDN 200
LETRVLMKKG YIWFDGEAML SAKTWPSPDM NRVLVMTDIQ SNWRHSYFGK 250
YWILDVATQK AEPLDPGNLS GRVQLAAWSP TSDAVVFVRE NNLYLRKLTS 300
LEVTPITKDG DENLFYGVPD WVYEEEVFSG NTGTWWSDDG KFVAFLRTNE 350
TAVPEYPIQY FRSRPSGKQP PPGLENYPEV RQIKYPKPGS PNPIVNLQFY 400
DVEKNEVFSF EMPEDFVDDE RIIIEVVWAS EGKVLIRETN RESDVVKIFV 450
MDTKARTGKL VRSDDIAALD GGWVEPTQST RVIPADPKNG RPHDGYVDTV 500
IYEGYDHLAY FTPFDNPEPV MLTKGNWEVV NAPSAVDLKK GLVYFVATKE 550
APTQRHVYSV KLDGSDLRPL TDTSAPGFFD VSFSHGAGYG LLSYKGPAVP 600
WQAVINTQGD EIDFINLIEE NVELAKMVEE SAIPTEVYSN VTIDGYTLQV 650
LERRPPNFNP EKKYPVLFFL YGGPGSQTVD RKFTIDFQTY VASNLGYIVV 700
TVDGRGTGFI GREARCLVRG NIGHYEAIDQ IETAKIWASK SYVDESRMAV 750
WGWSYGGYMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSI YTERYMHTPE 800
HNPSGYANAS IDDVMALGHS VRFLIMHGVA DDNVHLQNTL VLIDKLDLKN 850
IDNYDMQVFP DSDHSIQFHM AHALVYERLS SWLINAFNGE WHRTANPKPQ 900
EST 903
Length:903
Mass (Da):100,902
Last modified:December 16, 2008 - v1
Checksum:iD00566741A21990E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920435 Genomic DNA. Translation: CAP85936.1.
RefSeqiXP_002563136.1. XM_002563090.1.

Genome annotation databases

GeneIDi8310705.
KEGGipcs:Pc20g06070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920435 Genomic DNA. Translation: CAP85936.1 .
RefSeqi XP_002563136.1. XM_002563090.1.

3D structure databases

ProteinModelPortali B6HFS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6HFS8.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8310705.
KEGGi pcs:Pc20g06070.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01282.
OMAi MALMTMF.
OrthoDBi EOG72VHFG.

Enzyme and pathway databases

BioCyci PCHR:PC20G06070-MONOMER.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiDAPB_PENCW
AccessioniPrimary (citable) accession number: B6HFS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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