Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B6HFS8

- DAPB_PENCW

UniProt

B6HFS8 - DAPB_PENCW

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei754 – 7541Charge relay systemBy similarity
    Active sitei831 – 8311Charge relay systemBy similarity
    Active sitei864 – 8641Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciPCHR:PC20G06070-MONOMER.

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:Pc20g06070
    OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
    Taxonomic identifieri500485 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
    ProteomesiUP000000724: Contig Pc00c20

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 903903Probable dipeptidyl-aminopeptidase BPRO_0000412156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi500485.B6HFS8.

    Structurei

    3D structure databases

    ProteinModelPortaliB6HFS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 903792VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01282.
    OMAiMALMTMF.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6HFS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKFEDDGNS ESVPLTRQRS ESLASQTSTD SGLSIASESF MKNHKGGNTM    50
    PTDGGDGDRY LDVEDGGETG LDEPLISSGT KTGSSSRLRK IVWLLVLLCV 100
    GGWVLSFVLF LTQKRPDTAA LSSASTVEIH EPGPATGGTS HGKPVTLEQV 150
    LSGTWSPKSH AISWIAGPDG EDGLLVEQGE KQDAFLRVKD IRSSEDGVDN 200
    LETRVLMKKG YIWFDGEAML SAKTWPSPDM NRVLVMTDIQ SNWRHSYFGK 250
    YWILDVATQK AEPLDPGNLS GRVQLAAWSP TSDAVVFVRE NNLYLRKLTS 300
    LEVTPITKDG DENLFYGVPD WVYEEEVFSG NTGTWWSDDG KFVAFLRTNE 350
    TAVPEYPIQY FRSRPSGKQP PPGLENYPEV RQIKYPKPGS PNPIVNLQFY 400
    DVEKNEVFSF EMPEDFVDDE RIIIEVVWAS EGKVLIRETN RESDVVKIFV 450
    MDTKARTGKL VRSDDIAALD GGWVEPTQST RVIPADPKNG RPHDGYVDTV 500
    IYEGYDHLAY FTPFDNPEPV MLTKGNWEVV NAPSAVDLKK GLVYFVATKE 550
    APTQRHVYSV KLDGSDLRPL TDTSAPGFFD VSFSHGAGYG LLSYKGPAVP 600
    WQAVINTQGD EIDFINLIEE NVELAKMVEE SAIPTEVYSN VTIDGYTLQV 650
    LERRPPNFNP EKKYPVLFFL YGGPGSQTVD RKFTIDFQTY VASNLGYIVV 700
    TVDGRGTGFI GREARCLVRG NIGHYEAIDQ IETAKIWASK SYVDESRMAV 750
    WGWSYGGYMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSI YTERYMHTPE 800
    HNPSGYANAS IDDVMALGHS VRFLIMHGVA DDNVHLQNTL VLIDKLDLKN 850
    IDNYDMQVFP DSDHSIQFHM AHALVYERLS SWLINAFNGE WHRTANPKPQ 900
    EST 903
    Length:903
    Mass (Da):100,902
    Last modified:December 16, 2008 - v1
    Checksum:iD00566741A21990E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920435 Genomic DNA. Translation: CAP85936.1.
    RefSeqiXP_002563136.1. XM_002563090.1.

    Genome annotation databases

    GeneIDi8310705.
    KEGGipcs:Pc20g06070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920435 Genomic DNA. Translation: CAP85936.1 .
    RefSeqi XP_002563136.1. XM_002563090.1.

    3D structure databases

    ProteinModelPortali B6HFS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 500485.B6HFS8.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8310705.
    KEGGi pcs:Pc20g06070.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01282.
    OMAi MALMTMF.
    OrthoDBi EOG72VHFG.

    Enzyme and pathway databases

    BioCyci PCHR:PC20G06070-MONOMER.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

    Entry informationi

    Entry nameiDAPB_PENCW
    AccessioniPrimary (citable) accession number: B6HFS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3