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B6HFS8

- DAPB_PENCW

UniProt

B6HFS8 - DAPB_PENCW

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay systemBy similarity
Active sitei831 – 8311Charge relay systemBy similarity
Active sitei864 – 8641Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciPCHR:PC20G06070-MONOMER.

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:Pc20g06070
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c20

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Probable dipeptidyl-aminopeptidase BPRO_0000412156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.B6HFS8.

Structurei

3D structure databases

ProteinModelPortaliB6HFS8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini112 – 903792VacuolarSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01282.
OMAiMALMTMF.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B6HFS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKFEDDGNS ESVPLTRQRS ESLASQTSTD SGLSIASESF MKNHKGGNTM
60 70 80 90 100
PTDGGDGDRY LDVEDGGETG LDEPLISSGT KTGSSSRLRK IVWLLVLLCV
110 120 130 140 150
GGWVLSFVLF LTQKRPDTAA LSSASTVEIH EPGPATGGTS HGKPVTLEQV
160 170 180 190 200
LSGTWSPKSH AISWIAGPDG EDGLLVEQGE KQDAFLRVKD IRSSEDGVDN
210 220 230 240 250
LETRVLMKKG YIWFDGEAML SAKTWPSPDM NRVLVMTDIQ SNWRHSYFGK
260 270 280 290 300
YWILDVATQK AEPLDPGNLS GRVQLAAWSP TSDAVVFVRE NNLYLRKLTS
310 320 330 340 350
LEVTPITKDG DENLFYGVPD WVYEEEVFSG NTGTWWSDDG KFVAFLRTNE
360 370 380 390 400
TAVPEYPIQY FRSRPSGKQP PPGLENYPEV RQIKYPKPGS PNPIVNLQFY
410 420 430 440 450
DVEKNEVFSF EMPEDFVDDE RIIIEVVWAS EGKVLIRETN RESDVVKIFV
460 470 480 490 500
MDTKARTGKL VRSDDIAALD GGWVEPTQST RVIPADPKNG RPHDGYVDTV
510 520 530 540 550
IYEGYDHLAY FTPFDNPEPV MLTKGNWEVV NAPSAVDLKK GLVYFVATKE
560 570 580 590 600
APTQRHVYSV KLDGSDLRPL TDTSAPGFFD VSFSHGAGYG LLSYKGPAVP
610 620 630 640 650
WQAVINTQGD EIDFINLIEE NVELAKMVEE SAIPTEVYSN VTIDGYTLQV
660 670 680 690 700
LERRPPNFNP EKKYPVLFFL YGGPGSQTVD RKFTIDFQTY VASNLGYIVV
710 720 730 740 750
TVDGRGTGFI GREARCLVRG NIGHYEAIDQ IETAKIWASK SYVDESRMAV
760 770 780 790 800
WGWSYGGYMT LKVLEQDAGE TFQYGMAVAP VTDWRFYDSI YTERYMHTPE
810 820 830 840 850
HNPSGYANAS IDDVMALGHS VRFLIMHGVA DDNVHLQNTL VLIDKLDLKN
860 870 880 890 900
IDNYDMQVFP DSDHSIQFHM AHALVYERLS SWLINAFNGE WHRTANPKPQ

EST
Length:903
Mass (Da):100,902
Last modified:December 16, 2008 - v1
Checksum:iD00566741A21990E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920435 Genomic DNA. Translation: CAP85936.1.
RefSeqiXP_002563136.1. XM_002563090.1.

Genome annotation databases

GeneIDi8310705.
KEGGipcs:Pc20g06070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920435 Genomic DNA. Translation: CAP85936.1 .
RefSeqi XP_002563136.1. XM_002563090.1.

3D structure databases

ProteinModelPortali B6HFS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6HFS8.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8310705.
KEGGi pcs:Pc20g06070.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01282.
OMAi MALMTMF.
OrthoDBi EOG72VHFG.

Enzyme and pathway databases

BioCyci PCHR:PC20G06070-MONOMER.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiDAPB_PENCW
AccessioniPrimary (citable) accession number: B6HFS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3