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B6HFS8 (DAPB_PENCW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:Pc20g06070
OrganismPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]
Taxonomic identifier500485 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length903 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 903903Probable dipeptidyl-aminopeptidase B
PRO_0000412156

Regions

Topological domain1 – 9090Cytoplasmic Potential
Transmembrane91 – 11121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain112 – 903792Vacuolar Potential

Sites

Active site7541Charge relay system By similarity
Active site8311Charge relay system By similarity
Active site8641Charge relay system By similarity

Amino acid modifications

Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation6401N-linked (GlcNAc...) Potential
Glycosylation8081N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B6HFS8 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: D00566741A21990E

FASTA903100,902
        10         20         30         40         50         60 
MGKFEDDGNS ESVPLTRQRS ESLASQTSTD SGLSIASESF MKNHKGGNTM PTDGGDGDRY 

        70         80         90        100        110        120 
LDVEDGGETG LDEPLISSGT KTGSSSRLRK IVWLLVLLCV GGWVLSFVLF LTQKRPDTAA 

       130        140        150        160        170        180 
LSSASTVEIH EPGPATGGTS HGKPVTLEQV LSGTWSPKSH AISWIAGPDG EDGLLVEQGE 

       190        200        210        220        230        240 
KQDAFLRVKD IRSSEDGVDN LETRVLMKKG YIWFDGEAML SAKTWPSPDM NRVLVMTDIQ 

       250        260        270        280        290        300 
SNWRHSYFGK YWILDVATQK AEPLDPGNLS GRVQLAAWSP TSDAVVFVRE NNLYLRKLTS 

       310        320        330        340        350        360 
LEVTPITKDG DENLFYGVPD WVYEEEVFSG NTGTWWSDDG KFVAFLRTNE TAVPEYPIQY 

       370        380        390        400        410        420 
FRSRPSGKQP PPGLENYPEV RQIKYPKPGS PNPIVNLQFY DVEKNEVFSF EMPEDFVDDE 

       430        440        450        460        470        480 
RIIIEVVWAS EGKVLIRETN RESDVVKIFV MDTKARTGKL VRSDDIAALD GGWVEPTQST 

       490        500        510        520        530        540 
RVIPADPKNG RPHDGYVDTV IYEGYDHLAY FTPFDNPEPV MLTKGNWEVV NAPSAVDLKK 

       550        560        570        580        590        600 
GLVYFVATKE APTQRHVYSV KLDGSDLRPL TDTSAPGFFD VSFSHGAGYG LLSYKGPAVP 

       610        620        630        640        650        660 
WQAVINTQGD EIDFINLIEE NVELAKMVEE SAIPTEVYSN VTIDGYTLQV LERRPPNFNP 

       670        680        690        700        710        720 
EKKYPVLFFL YGGPGSQTVD RKFTIDFQTY VASNLGYIVV TVDGRGTGFI GREARCLVRG 

       730        740        750        760        770        780 
NIGHYEAIDQ IETAKIWASK SYVDESRMAV WGWSYGGYMT LKVLEQDAGE TFQYGMAVAP 

       790        800        810        820        830        840 
VTDWRFYDSI YTERYMHTPE HNPSGYANAS IDDVMALGHS VRFLIMHGVA DDNVHLQNTL 

       850        860        870        880        890        900 
VLIDKLDLKN IDNYDMQVFP DSDHSIQFHM AHALVYERLS SWLINAFNGE WHRTANPKPQ 


EST 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM920435 Genomic DNA. Translation: CAP85936.1.
RefSeqXP_002563136.1. XM_002563090.1.

3D structure databases

ProteinModelPortalB6HFS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING500485.B6HFS8.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8310705.
KEGGpcs:Pc20g06070.

Phylogenomic databases

eggNOGCOG1506.
HOGENOMHOG000189891.
KOK01282.
OMAETKFWYQ.
OrthoDBEOG72VHFG.

Enzyme and pathway databases

BioCycPCHR:PC20G06070-MONOMER.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_PENCW
AccessionPrimary (citable) accession number: B6HFS8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries