ID   B6HEK2_PENRW            Unreviewed;       788 AA.
AC   B6HEK2;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Pc20g07700 protein {ECO:0000313|EMBL:CAP86099.1};
GN   ORFNames=Pc20g07700 {ECO:0000313|EMBL:CAP86099.1}, PCH_Pc20g07700
GN   {ECO:0000313|EMBL:CAP86099.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP86099.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP86099.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM920435; CAP86099.1; -; Genomic_DNA.
DR   RefSeq; XP_002563293.1; XM_002563247.1.
DR   AlphaFoldDB; B6HEK2; -.
DR   STRING; 500485.B6HEK2; -.
DR   GeneID; 8313361; -.
DR   KEGG; pcs:Pc20g07700; -.
DR   VEuPathDB; FungiDB:PCH_Pc20g07700; -.
DR   eggNOG; KOG1083; Eukaryota.
DR   HOGENOM; CLU_004379_3_0_1; -.
DR   OMA; NCQNRYM; -.
DR   OrthoDB; 950362at2759; -.
DR   BioCyc; PCHR:PC20G07700-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF512; N-METHYLTRANSFERASE (ASH1), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06480)-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          384..430
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          441..557
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          565..581
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..272
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..604
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..634
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..680
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        691..715
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        745..759
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  86467 MW;  19B0E70A567FD0AC CRC64;
     MAPRTSRSVA SAAPDAQAHE PTDDNMSLDV PEQLLTPENS RSETSSNNEN ALADEKPAGR
     RRSTRVARAS LRPGEPLDDT NKEPAASSSE AYVDSLAKAK RSHSSLRHSI AVMESSLWSG
     APVDDDTVAD DTAAPDTPVS KSSQDLQSED MNTALQQRTL RKRVGKALVE DEGTPTAGVV
     PTRTSPRKSL RRSGRFSLMD KASDLVDRAS SILGKRTRGL ADKDLGRRAS LRPRNNAPSK
     DETALSAVNE PASKKRRVSE SDLSKLQDQD TPEPEEPAVS ASRPRKIWLS HGLYTGQEPS
     DSPPKQRRSK NSKKTGTGPM QRTILPMPMF KGARLLKTGR DYQLPYDIFS PLPPGQPKPN
     EWRKTNKNVF VGDAGSFWKA NKKLELSTCM CTEDTGCDEN CQNRYMFYEC DNGNCRLGPE
     CGNRNFEGLK QRTKAGGKYN IGVEVIKTAD RGYGVRSNRS FEPNQIIVEY TGEILTQLEC
     EKRMRTVYKN NDCYYLMYFD QNMIIDATRG SIARFVNHAC EPNCRMEKWT VAGKPRMALF
     AGDRGVSTGE ELSYDYNFDP YSNKNVQECR CGSANCRGFL GPRLKEKQQR AKELEKRKAE
     GSPKTTTAKK VIGKKRKASE EAESDDEAPQ GKKRKIIRSK SIKAGVKKAV AAVRGKKTTK
     TTAKGKTTTA VKSKTNVKLP TVKATGRIKA TVRASRSNKT AKETPASPKK TTSQLKRPSA
     ETKKKILATA SKGSGASPRK PAKRVPAKSP VKAKKPAPKA KSTPKGGFGK GVKSAARRVM
     KSVKGSKK
//