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B6H7A4

- KEX1_PENCW

UniProt

B6H7A4 - KEX1_PENCW

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation
Active sitei369 – 3691PROSITE-ProRule annotation
Active sitei431 – 4311PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciPCHR:PC16G01980-MONOMER.

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:Pc16g01980
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 502483LumenalSequence AnalysisAdd
BLAST
Transmembranei503 – 52321HelicalSequence AnalysisAdd
BLAST
Topological domaini524 – 60784CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 607588Pheromone-processing carboxypeptidase kex1PRO_5000409185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.B6H7A4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H7A4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLSALSLLL SPLVSASSAA DYYVRSLPGA PEGPFLKMHA GHIEVDPDTN
60 70 80 90 100
GNLFFWHFQN RHIANRQRTV IWLNGGPGCS SMDGAFMEVG PYRLQDDHTL
110 120 130 140 150
KYNEGRWDEF ANLLFVDNPV GTGFSYANTN SYLHELDEMA AHFVIFLEKF
160 170 180 190 200
FELFPEYAND DLYIAGESYA GQHIPYIAKA IQDRNKGITE NGGTKWPLKG
210 220 230 240 250
LLIGNGWISP ADQYPSYFKF IEREGLAKPG TSLHHNINAL NEVCLSKLET
260 270 280 290 300
PGAKNKLDVG ACELVLQQFL DLTTEDHQCY NMYDVRLKDE AKSCGMNWPP
310 320 330 340 350
DLKNIEPYLQ RPDVVKALNI NPAKKSGWTE CAGMVHMAFT AKNSIPSVHL
360 370 380 390 400
LPGLIESGIN VLLFSGDKDL ICNHIGTETL IHNMDWKGGT GFETSPGVWA
410 420 430 440 450
PRHDWSFEGE PAGIYQSARN LTYVLFYNSS HMVPFDNPRQ SRDMLDRFMK
460 470 480 490 500
VDIASIGGQP SDSRIDGEKL PQTAVGGQAN STAAEQNEKE RLKQTEMHAY
510 520 530 540 550
TKSGEAVLII VIIGVIAWGF FIWRSRRTRR GYKGVSNNDM SDSTSVLSRF
560 570 580 590 600
QNKHSGRDVE AGDFDEAELD QLHSPSIERE DYAVGEASDD DDHIISHPET

GGNRQSS
Length:607
Mass (Da):67,721
Last modified:December 16, 2008 - v1
Checksum:iCDE50C5072988A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920431 Genomic DNA. Translation: CAP92868.1.
RefSeqiXP_002560571.1. XM_002560525.1.

Genome annotation databases

GeneIDi8313930.
KEGGipcs:Pc16g01980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920431 Genomic DNA. Translation: CAP92868.1 .
RefSeqi XP_002560571.1. XM_002560525.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6H7A4.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8313930.
KEGGi pcs:Pc16g01980.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000208879.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Enzyme and pathway databases

BioCyci PCHR:PC16G01980-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiKEX1_PENCW
AccessioniPrimary (citable) accession number: B6H7A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3