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B6H7A4 (KEX1_PENCW) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:Pc16g01980
OrganismPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]
Taxonomic identifier500485 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 607588Pheromone-processing carboxypeptidase kex1
PRO_5000409185

Regions

Topological domain20 – 502483Lumenal Potential
Transmembrane503 – 52321Helical; Potential
Topological domain524 – 60784Cytoplasmic Potential

Sites

Active site1681 By similarity
Active site3691 By similarity
Active site4311 By similarity

Amino acid modifications

Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B6H7A4 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CDE50C5072988A69

FASTA60767,721
        10         20         30         40         50         60 
MLLSALSLLL SPLVSASSAA DYYVRSLPGA PEGPFLKMHA GHIEVDPDTN GNLFFWHFQN 

        70         80         90        100        110        120 
RHIANRQRTV IWLNGGPGCS SMDGAFMEVG PYRLQDDHTL KYNEGRWDEF ANLLFVDNPV 

       130        140        150        160        170        180 
GTGFSYANTN SYLHELDEMA AHFVIFLEKF FELFPEYAND DLYIAGESYA GQHIPYIAKA 

       190        200        210        220        230        240 
IQDRNKGITE NGGTKWPLKG LLIGNGWISP ADQYPSYFKF IEREGLAKPG TSLHHNINAL 

       250        260        270        280        290        300 
NEVCLSKLET PGAKNKLDVG ACELVLQQFL DLTTEDHQCY NMYDVRLKDE AKSCGMNWPP 

       310        320        330        340        350        360 
DLKNIEPYLQ RPDVVKALNI NPAKKSGWTE CAGMVHMAFT AKNSIPSVHL LPGLIESGIN 

       370        380        390        400        410        420 
VLLFSGDKDL ICNHIGTETL IHNMDWKGGT GFETSPGVWA PRHDWSFEGE PAGIYQSARN 

       430        440        450        460        470        480 
LTYVLFYNSS HMVPFDNPRQ SRDMLDRFMK VDIASIGGQP SDSRIDGEKL PQTAVGGQAN 

       490        500        510        520        530        540 
STAAEQNEKE RLKQTEMHAY TKSGEAVLII VIIGVIAWGF FIWRSRRTRR GYKGVSNNDM 

       550        560        570        580        590        600 
SDSTSVLSRF QNKHSGRDVE AGDFDEAELD QLHSPSIERE DYAVGEASDD DDHIISHPET 


GGNRQSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM920431 Genomic DNA. Translation: CAP92868.1.
RefSeqXP_002560571.1. XM_002560525.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING500485.B6H7A4.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8313930.
KEGGpcs:Pc16g01980.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000208879.
KOK01288.
OMANECINSY.
OrthoDBEOG7TJ3SJ.

Enzyme and pathway databases

BioCycPCHR:PC16G01980-MONOMER.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PENCW
AccessionPrimary (citable) accession number: B6H7A4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries