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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168PROSITE-ProRule annotation1
Active sitei369PROSITE-ProRule annotation1
Active sitei431PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciPCHR:PC16G01980-MONOMER.

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:Pc16g01980
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c16

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 502LumenalSequence analysisAdd BLAST483
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 607CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500040918520 – 607Pheromone-processing carboxypeptidase kex1Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002560571.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000208879.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H7A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSALSLLL SPLVSASSAA DYYVRSLPGA PEGPFLKMHA GHIEVDPDTN
60 70 80 90 100
GNLFFWHFQN RHIANRQRTV IWLNGGPGCS SMDGAFMEVG PYRLQDDHTL
110 120 130 140 150
KYNEGRWDEF ANLLFVDNPV GTGFSYANTN SYLHELDEMA AHFVIFLEKF
160 170 180 190 200
FELFPEYAND DLYIAGESYA GQHIPYIAKA IQDRNKGITE NGGTKWPLKG
210 220 230 240 250
LLIGNGWISP ADQYPSYFKF IEREGLAKPG TSLHHNINAL NEVCLSKLET
260 270 280 290 300
PGAKNKLDVG ACELVLQQFL DLTTEDHQCY NMYDVRLKDE AKSCGMNWPP
310 320 330 340 350
DLKNIEPYLQ RPDVVKALNI NPAKKSGWTE CAGMVHMAFT AKNSIPSVHL
360 370 380 390 400
LPGLIESGIN VLLFSGDKDL ICNHIGTETL IHNMDWKGGT GFETSPGVWA
410 420 430 440 450
PRHDWSFEGE PAGIYQSARN LTYVLFYNSS HMVPFDNPRQ SRDMLDRFMK
460 470 480 490 500
VDIASIGGQP SDSRIDGEKL PQTAVGGQAN STAAEQNEKE RLKQTEMHAY
510 520 530 540 550
TKSGEAVLII VIIGVIAWGF FIWRSRRTRR GYKGVSNNDM SDSTSVLSRF
560 570 580 590 600
QNKHSGRDVE AGDFDEAELD QLHSPSIERE DYAVGEASDD DDHIISHPET

GGNRQSS
Length:607
Mass (Da):67,721
Last modified:December 16, 2008 - v1
Checksum:iCDE50C5072988A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920431 Genomic DNA. Translation: CAP92868.1.
RefSeqiXP_002560571.1. XM_002560525.1.

Genome annotation databases

EnsemblFungiiCAP92868; CAP92868; PCH_Pc16g01980.
GeneIDi8313930.
KEGGipcs:Pc16g01980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920431 Genomic DNA. Translation: CAP92868.1.
RefSeqiXP_002560571.1. XM_002560525.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002560571.1.

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP92868; CAP92868; PCH_Pc16g01980.
GeneIDi8313930.
KEGGipcs:Pc16g01980.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000208879.
KOiK01288.
OrthoDBiEOG092C255X.

Enzyme and pathway databases

BioCyciPCHR:PC16G01980-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_PENRW
AccessioniPrimary (citable) accession number: B6H7A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.