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B6H7A4

- KEX1_PENCW

UniProt

B6H7A4 - KEX1_PENCW

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681PROSITE-ProRule annotation
    Active sitei369 – 3691PROSITE-ProRule annotation
    Active sitei431 – 4311PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    BioCyciPCHR:PC16G01980-MONOMER.

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:Pc16g01980
    OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
    Taxonomic identifieri500485 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
    ProteomesiUP000000724: Contig Pc00c16

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 607588Pheromone-processing carboxypeptidase kex1PRO_5000409185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi500485.B6H7A4.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 502483LumenalSequence AnalysisAdd
    BLAST
    Topological domaini524 – 60784CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei503 – 52321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000208879.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6H7A4-1 [UniParc]FASTAAdd to Basket

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    MLLSALSLLL SPLVSASSAA DYYVRSLPGA PEGPFLKMHA GHIEVDPDTN    50
    GNLFFWHFQN RHIANRQRTV IWLNGGPGCS SMDGAFMEVG PYRLQDDHTL 100
    KYNEGRWDEF ANLLFVDNPV GTGFSYANTN SYLHELDEMA AHFVIFLEKF 150
    FELFPEYAND DLYIAGESYA GQHIPYIAKA IQDRNKGITE NGGTKWPLKG 200
    LLIGNGWISP ADQYPSYFKF IEREGLAKPG TSLHHNINAL NEVCLSKLET 250
    PGAKNKLDVG ACELVLQQFL DLTTEDHQCY NMYDVRLKDE AKSCGMNWPP 300
    DLKNIEPYLQ RPDVVKALNI NPAKKSGWTE CAGMVHMAFT AKNSIPSVHL 350
    LPGLIESGIN VLLFSGDKDL ICNHIGTETL IHNMDWKGGT GFETSPGVWA 400
    PRHDWSFEGE PAGIYQSARN LTYVLFYNSS HMVPFDNPRQ SRDMLDRFMK 450
    VDIASIGGQP SDSRIDGEKL PQTAVGGQAN STAAEQNEKE RLKQTEMHAY 500
    TKSGEAVLII VIIGVIAWGF FIWRSRRTRR GYKGVSNNDM SDSTSVLSRF 550
    QNKHSGRDVE AGDFDEAELD QLHSPSIERE DYAVGEASDD DDHIISHPET 600
    GGNRQSS 607
    Length:607
    Mass (Da):67,721
    Last modified:December 16, 2008 - v1
    Checksum:iCDE50C5072988A69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920431 Genomic DNA. Translation: CAP92868.1.
    RefSeqiXP_002560571.1. XM_002560525.1.

    Genome annotation databases

    GeneIDi8313930.
    KEGGipcs:Pc16g01980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920431 Genomic DNA. Translation: CAP92868.1 .
    RefSeqi XP_002560571.1. XM_002560525.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 500485.B6H7A4.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8313930.
    KEGGi pcs:Pc16g01980.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000208879.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Enzyme and pathway databases

    BioCyci PCHR:PC16G01980-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

    Entry informationi

    Entry nameiKEX1_PENCW
    AccessioniPrimary (citable) accession number: B6H7A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3