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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei126Substrate; via amide nitrogenBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1
Active sitei186Proton donorSequence analysis1
Binding sitei249SubstrateBy similarity1
Active sitei285NucleophileSequence analysis1
Binding sitei351SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciPCHR:PC14G01510-MONOMER

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:Pc14g01510
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum species complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500040911422 – 982Probable beta-galactosidase CAdd BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi255 ↔ 302By similarity
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi675N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi718N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi785N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiB6H5X9

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002560145.1

Structurei

3D structure databases

ProteinModelPortaliB6H5X9
SMRiB6H5X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496 Eukaryota
COG1874 LUCA
HOGENOMiHOG000181922
OMAiEFEGGWF
OrthoDBiEOG092C0SLI

Family and domain databases

Gene3Di2.102.20.10, 1 hit
2.60.120.260, 2 hits
2.60.390.10, 1 hit
InterProiView protein in InterPro
IPR018954 Betagal_dom2
IPR037110 Betagal_dom2_sf
IPR025972 BetaGal_dom3
IPR036833 BetaGal_dom3_sf
IPR025300 BetaGal_jelly_roll_dom
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF10435 BetaGal_dom2, 1 hit
PF13363 BetaGal_dom3, 1 hit
PF13364 BetaGal_dom4_5, 2 hits
PF01301 Glyco_hydro_35, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SMARTiView protein in SMART
SM01029 BetaGal_dom2, 1 hit
SUPFAMiSSF117100 SSF117100, 1 hit
SSF49785 SSF49785, 2 hits
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H5X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE
60 70 80 90 100
FHYQRLPVPE LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH
110 120 130 140 150
DVQRVFDYAK QAGLYVIARA GPYCNAETSA GGFALWASNG QMGSTRTSAS
160 170 180 190 200
SYYDRWYPWI QEIGKIIAAN QITNGGPVIL NQHENELQET IHSADNTVVK
210 220 230 240 250
YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA VNIYGLDSYP
260 270 280 290 300
GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD
310 320 330 340 350
QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD
360 370 380 390 400
YSAPMRETRE IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY
410 420 430 440 450
TWALRNPETH AGFYVLAHST SSSRAVTTTS LNVNTSAGAL TIPNIELAGR
460 470 480 490 500
QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL DVDVIVFYLN IGQKGEFAFK
510 520 530 540 550
DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF SHGVLVYLLD
560 570 580 590 600
KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN
610 620 630 640 650
ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL
660 670 680 690 700
KSWKAQDTLP EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA
710 720 730 740 750
GTKIYRGRFD GVTATGANIT VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT
760 770 780 790 800
SAELEFTSST LRRKDNVLTV VMDYTGHDQA NVKPNGSQNP RGILGATLLG
810 820 830 840 850
GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP GYKGSKTATS
860 870 880 890 900
ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN
910 920 930 940 950
GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD
960 970 980
LVAYGAYRTG FNFNHDWSYL QPQWENNRGQ YV
Length:982
Mass (Da):107,330
Last modified:December 16, 2008 - v1
Checksum:iCB71A29036AA41A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920429 Genomic DNA Translation: CAP74292.1
RefSeqiXP_002560145.1, XM_002560099.1

Genome annotation databases

EnsemblFungiiCAP74292; CAP74292; PCH_Pc14g01510
GeneIDi8314314
KEGGipcs:Pc14g01510

Similar proteinsi

Entry informationi

Entry nameiBGALC_PENRW
AccessioniPrimary (citable) accession number: B6H5X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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