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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei126Substrate; via amide nitrogenBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1
Active sitei186Proton donorSequence analysis1
Binding sitei249SubstrateBy similarity1
Active sitei285NucleophileSequence analysis1
Binding sitei351SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciPCHR:PC14G01510-MONOMER.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:Pc14g01510
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500040911422 – 982Probable beta-galactosidase CAdd BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi255 ↔ 302By similarity
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi600N-linked (GlcNAc...)Sequence analysis1
Glycosylationi675N-linked (GlcNAc...)Sequence analysis1
Glycosylationi718N-linked (GlcNAc...)Sequence analysis1
Glycosylationi785N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002560145.1.

Structurei

3D structure databases

ProteinModelPortaliB6H5X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H5X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE
60 70 80 90 100
FHYQRLPVPE LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH
110 120 130 140 150
DVQRVFDYAK QAGLYVIARA GPYCNAETSA GGFALWASNG QMGSTRTSAS
160 170 180 190 200
SYYDRWYPWI QEIGKIIAAN QITNGGPVIL NQHENELQET IHSADNTVVK
210 220 230 240 250
YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA VNIYGLDSYP
260 270 280 290 300
GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD
310 320 330 340 350
QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD
360 370 380 390 400
YSAPMRETRE IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY
410 420 430 440 450
TWALRNPETH AGFYVLAHST SSSRAVTTTS LNVNTSAGAL TIPNIELAGR
460 470 480 490 500
QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL DVDVIVFYLN IGQKGEFAFK
510 520 530 540 550
DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF SHGVLVYLLD
560 570 580 590 600
KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN
610 620 630 640 650
ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL
660 670 680 690 700
KSWKAQDTLP EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA
710 720 730 740 750
GTKIYRGRFD GVTATGANIT VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT
760 770 780 790 800
SAELEFTSST LRRKDNVLTV VMDYTGHDQA NVKPNGSQNP RGILGATLLG
810 820 830 840 850
GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP GYKGSKTATS
860 870 880 890 900
ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN
910 920 930 940 950
GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD
960 970 980
LVAYGAYRTG FNFNHDWSYL QPQWENNRGQ YV
Length:982
Mass (Da):107,330
Last modified:December 16, 2008 - v1
Checksum:iCB71A29036AA41A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1.
RefSeqiXP_002560145.1. XM_002560099.1.

Genome annotation databases

EnsemblFungiiCAP74292; CAP74292; PCH_Pc14g01510.
GeneIDi8314314.
KEGGipcs:Pc14g01510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1.
RefSeqiXP_002560145.1. XM_002560099.1.

3D structure databases

ProteinModelPortaliB6H5X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002560145.1.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP74292; CAP74292; PCH_Pc14g01510.
GeneIDi8314314.
KEGGipcs:Pc14g01510.

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Enzyme and pathway databases

BioCyciPCHR:PC14G01510-MONOMER.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGALC_PENRW
AccessioniPrimary (citable) accession number: B6H5X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.