Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6H5X9

- BGALC_PENCW

UniProt

B6H5X9 - BGALC_PENCW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801SubstrateBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei126 – 1261Substrate; via amide nitrogenBy similarity
Binding sitei127 – 1271SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity
Active sitei186 – 1861Proton donorSequence Analysis
Binding sitei249 – 2491SubstrateBy similarity
Active sitei285 – 2851NucleophileSequence Analysis
Binding sitei351 – 3511SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciPCHR:PC14G01510-MONOMER.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:Pc14g01510
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c14

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 982961Probable beta-galactosidase CPRO_5000409114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 302By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi785 – 7851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.B6H5X9.

Structurei

3D structure databases

ProteinModelPortaliB6H5X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H5X9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE
60 70 80 90 100
FHYQRLPVPE LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH
110 120 130 140 150
DVQRVFDYAK QAGLYVIARA GPYCNAETSA GGFALWASNG QMGSTRTSAS
160 170 180 190 200
SYYDRWYPWI QEIGKIIAAN QITNGGPVIL NQHENELQET IHSADNTVVK
210 220 230 240 250
YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA VNIYGLDSYP
260 270 280 290 300
GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD
310 320 330 340 350
QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD
360 370 380 390 400
YSAPMRETRE IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY
410 420 430 440 450
TWALRNPETH AGFYVLAHST SSSRAVTTTS LNVNTSAGAL TIPNIELAGR
460 470 480 490 500
QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL DVDVIVFYLN IGQKGEFAFK
510 520 530 540 550
DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF SHGVLVYLLD
560 570 580 590 600
KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN
610 620 630 640 650
ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL
660 670 680 690 700
KSWKAQDTLP EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA
710 720 730 740 750
GTKIYRGRFD GVTATGANIT VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT
760 770 780 790 800
SAELEFTSST LRRKDNVLTV VMDYTGHDQA NVKPNGSQNP RGILGATLLG
810 820 830 840 850
GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP GYKGSKTATS
860 870 880 890 900
ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN
910 920 930 940 950
GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD
960 970 980
LVAYGAYRTG FNFNHDWSYL QPQWENNRGQ YV
Length:982
Mass (Da):107,330
Last modified:December 16, 2008 - v1
Checksum:iCB71A29036AA41A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1.
RefSeqiXP_002560145.1. XM_002560099.1.

Genome annotation databases

GeneIDi8314314.
KEGGipcs:Pc14g01510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1 .
RefSeqi XP_002560145.1. XM_002560099.1.

3D structure databases

ProteinModelPortali B6H5X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6H5X9.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8314314.
KEGGi pcs:Pc14g01510.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Enzyme and pathway databases

BioCyci PCHR:PC14G01510-MONOMER.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiBGALC_PENCW
AccessioniPrimary (citable) accession number: B6H5X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3