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B6H5X9 (BGALC_PENCW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase C

EC=3.2.1.23
Alternative name(s):
Lactase C
Gene names
Name:lacC
ORF Names:Pc14g01510
OrganismPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]
Taxonomic identifier500485 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length982 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 982961Probable beta-galactosidase C
PRO_5000409114

Sites

Active site1861Proton donor Potential
Active site2851Nucleophile Potential
Binding site801Substrate By similarity
Binding site1251Substrate By similarity
Binding site1261Substrate; via amide nitrogen By similarity
Binding site1271Substrate By similarity
Binding site1851Substrate By similarity
Binding site2491Substrate By similarity
Binding site3511Substrate By similarity

Amino acid modifications

Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation6001N-linked (GlcNAc...) Potential
Glycosylation6751N-linked (GlcNAc...) Potential
Glycosylation7181N-linked (GlcNAc...) Potential
Glycosylation7851N-linked (GlcNAc...) Potential
Disulfide bond255 ↔ 302 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6H5X9 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CB71A29036AA41A1

FASTA982107,330
        10         20         30         40         50         60 
MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE FHYQRLPVPE 

        70         80         90        100        110        120 
LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH DVQRVFDYAK QAGLYVIARA 

       130        140        150        160        170        180 
GPYCNAETSA GGFALWASNG QMGSTRTSAS SYYDRWYPWI QEIGKIIAAN QITNGGPVIL 

       190        200        210        220        230        240 
NQHENELQET IHSADNTVVK YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA 

       250        260        270        280        290        300 
VNIYGLDSYP GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD 

       310        320        330        340        350        360 
QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD YSAPMRETRE 

       370        380        390        400        410        420 
IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY TWALRNPETH AGFYVLAHST 

       430        440        450        460        470        480 
SSSRAVTTTS LNVNTSAGAL TIPNIELAGR QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL 

       490        500        510        520        530        540 
DVDVIVFYLN IGQKGEFAFK DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF 

       550        560        570        580        590        600 
SHGVLVYLLD KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN 

       610        620        630        640        650        660 
ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL KSWKAQDTLP 

       670        680        690        700        710        720 
EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA GTKIYRGRFD GVTATGANIT 

       730        740        750        760        770        780 
VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT SAELEFTSST LRRKDNVLTV VMDYTGHDQA 

       790        800        810        820        830        840 
NVKPNGSQNP RGILGATLLG GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP 

       850        860        870        880        890        900 
GYKGSKTATS ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN 

       910        920        930        940        950        960 
GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD LVAYGAYRTG 

       970        980 
FNFNHDWSYL QPQWENNRGQ YV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM920429 Genomic DNA. Translation: CAP74292.1.
RefSeqXP_002560145.1. XM_002560099.1.

3D structure databases

ProteinModelPortalB6H5X9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING500485.B6H5X9.

Protein family/group databases

CAZyGH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8314314.
KEGGpcs:Pc14g01510.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OMASGEFHYQ.
OrthoDBEOG7ZGXBD.

Enzyme and pathway databases

BioCycPCHR:PC14G01510-MONOMER.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALC_PENCW
AccessionPrimary (citable) accession number: B6H5X9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries