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B6H5X9

- BGALC_PENCW

UniProt

B6H5X9 - BGALC_PENCW

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Protein
Probable beta-galactosidase C
Gene
lacC, Pc14g01510
Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei126 – 1261Substrate; via amide nitrogen By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Active sitei186 – 1861Proton donor Reviewed prediction
Binding sitei249 – 2491Substrate By similarity
Active sitei285 – 2851Nucleophile Reviewed prediction
Binding sitei351 – 3511Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciPCHR:PC14G01510-MONOMER.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:Pc14g01510
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c14

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 982961Probable beta-galactosidase C
PRO_5000409114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 302 By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi389 – 3891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi675 – 6751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi718 – 7181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi785 – 7851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.B6H5X9.

Structurei

3D structure databases

ProteinModelPortaliB6H5X9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H5X9-1 [UniParc]FASTAAdd to Basket

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MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE    50
FHYQRLPVPE LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH 100
DVQRVFDYAK QAGLYVIARA GPYCNAETSA GGFALWASNG QMGSTRTSAS 150
SYYDRWYPWI QEIGKIIAAN QITNGGPVIL NQHENELQET IHSADNTVVK 200
YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA VNIYGLDSYP 250
GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD 300
QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD 350
YSAPMRETRE IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY 400
TWALRNPETH AGFYVLAHST SSSRAVTTTS LNVNTSAGAL TIPNIELAGR 450
QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL DVDVIVFYLN IGQKGEFAFK 500
DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF SHGVLVYLLD 550
KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN 600
ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL 650
KSWKAQDTLP EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA 700
GTKIYRGRFD GVTATGANIT VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT 750
SAELEFTSST LRRKDNVLTV VMDYTGHDQA NVKPNGSQNP RGILGATLLG 800
GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP GYKGSKTATS 850
ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN 900
GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD 950
LVAYGAYRTG FNFNHDWSYL QPQWENNRGQ YV 982
Length:982
Mass (Da):107,330
Last modified:December 16, 2008 - v1
Checksum:iCB71A29036AA41A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1.
RefSeqiXP_002560145.1. XM_002560099.1.

Genome annotation databases

GeneIDi8314314.
KEGGipcs:Pc14g01510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74292.1 .
RefSeqi XP_002560145.1. XM_002560099.1.

3D structure databases

ProteinModelPortali B6H5X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6H5X9.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8314314.
KEGGi pcs:Pc14g01510.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Enzyme and pathway databases

BioCyci PCHR:PC14G01510-MONOMER.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiBGALC_PENCW
AccessioniPrimary (citable) accession number: B6H5X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi