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B6H5X9

- BGALC_PENCW

UniProt

B6H5X9 - BGALC_PENCW

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei126 – 1261Substrate; via amide nitrogenBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Active sitei186 – 1861Proton donorSequence Analysis
    Binding sitei249 – 2491SubstrateBy similarity
    Active sitei285 – 2851NucleophileSequence Analysis
    Binding sitei351 – 3511SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciPCHR:PC14G01510-MONOMER.

    Protein family/group databases

    CAZyiGH35. Glycoside Hydrolase Family 35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase C (EC:3.2.1.23)
    Alternative name(s):
    Lactase C
    Gene namesi
    Name:lacC
    ORF Names:Pc14g01510
    OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
    Taxonomic identifieri500485 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
    ProteomesiUP000000724: Contig Pc00c14

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 982961Probable beta-galactosidase CPRO_5000409114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi255 ↔ 302By similarity
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi785 – 7851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi500485.B6H5X9.

    Structurei

    3D structure databases

    ProteinModelPortaliB6H5X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    HOGENOMiHOG000181922.
    OMAiSGEFHYQ.
    OrthoDBiEOG7ZGXBD.

    Family and domain databases

    Gene3Di2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SMARTiSM01029. BetaGal_dom2. 1 hit.
    [Graphical view]
    SUPFAMiSSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6H5X9-1 [UniParc]FASTAAdd to Basket

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    MRLFALLPVL LGLISSHFVS ATDNGKTTDV TWDKYSLSVK GERVYVFSGE    50
    FHYQRLPVPE LWLDVFQKLR ANGFNAISIY FFWSFHSASE DTFDFENGAH 100
    DVQRVFDYAK QAGLYVIARA GPYCNAETSA GGFALWASNG QMGSTRTSAS 150
    SYYDRWYPWI QEIGKIIAAN QITNGGPVIL NQHENELQET IHSADNTVVK 200
    YMEQIKAAFS DAGIIVPSTH NEKGMRSMSW STDYQDVGGA VNIYGLDSYP 250
    GGLSCTNPNS GFNLVRTYYQ WFQNYSSSQP EYLPEFEGGW FSAWGGSFYD 300
    QCSTELSPEF ADVYYKNNIG SRVTLHNIYM VMGATSWGQS AAPVVYTSYD 350
    YSAPMRETRE IRDKLKQTKL IGLFTRVSSG LLQTQMEGNG TGYTSDASIY 400
    TWALRNPETH AGFYVLAHST SSSRAVTTTS LNVNTSAGAL TIPNIELAGR 450
    QSKIIVTDYQ TGDGSSLLYS SAEVLTYATL DVDVIVFYLN IGQKGEFAFK 500
    DAPTHLTFKT YGNSKVSSAK SDHGTKYTYC QGDGTTVLKF SHGVLVYLLD 550
    KETAWNFFAV PTTSNPRVAP SEQILALGPY LVRTASVSGH TVSLVGDNAN 600
    ATSLEVYTGN SKVTQIKWNG KETPTKKTAY GSLIGSAPGA EHAKLSLPTL 650
    KSWKAQDTLP EINPDYDDSR WTVCNKTTSV NSVAPLTLPV LYSGDYGYHA 700
    GTKIYRGRFD GVTATGANIT VQNGVAAGWA AWLNGVYVGG AIGDPDLAAT 750
    SAELEFTSST LRRKDNVLTV VMDYTGHDQA NVKPNGSQNP RGILGATLLG 800
    GDFTSWRIQG NAGGEANIDP VRGPMNEGGL YGERLGWHLP GYKGSKTATS 850
    ESPLDGVSGA AGRFYTTTFK LDLDSDLDVP IGLQLGASAD APAVVQIFMN 900
    GYQFGHYLPH IGPQTRFPFP PGVINNRGEN TLAISLWALT EQGARLSQVD 950
    LVAYGAYRTG FNFNHDWSYL QPQWENNRGQ YV 982
    Length:982
    Mass (Da):107,330
    Last modified:December 16, 2008 - v1
    Checksum:iCB71A29036AA41A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920429 Genomic DNA. Translation: CAP74292.1.
    RefSeqiXP_002560145.1. XM_002560099.1.

    Genome annotation databases

    GeneIDi8314314.
    KEGGipcs:Pc14g01510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM920429 Genomic DNA. Translation: CAP74292.1 .
    RefSeqi XP_002560145.1. XM_002560099.1.

    3D structure databases

    ProteinModelPortali B6H5X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 500485.B6H5X9.

    Protein family/group databases

    CAZyi GH35. Glycoside Hydrolase Family 35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8314314.
    KEGGi pcs:Pc14g01510.

    Phylogenomic databases

    eggNOGi COG1874.
    HOGENOMi HOG000181922.
    OMAi SGEFHYQ.
    OrthoDBi EOG7ZGXBD.

    Enzyme and pathway databases

    BioCyci PCHR:PC14G01510-MONOMER.

    Family and domain databases

    Gene3Di 2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SMARTi SM01029. BetaGal_dom2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

    Entry informationi

    Entry nameiBGALC_PENCW
    AccessioniPrimary (citable) accession number: B6H5X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3