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B6H5L5

- MAP21_PENCW

UniProt

B6H5L5 - MAP21_PENCW

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Protein
Methionine aminopeptidase 2-1
Gene
Pc14g00010
Organism
Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161Substrate By similarity
Metal bindingi237 – 2371Divalent metal cation 1 By similarity
Metal bindingi248 – 2481Divalent metal cation 1 By similarity
Metal bindingi248 – 2481Divalent metal cation 2; catalytic By similarity
Metal bindingi317 – 3171Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei325 – 3251Substrate By similarity
Metal bindingi350 – 3501Divalent metal cation 2; catalytic By similarity
Metal bindingi446 – 4461Divalent metal cation 1 By similarity
Metal bindingi446 – 4461Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciPCHR:PC14G00010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1 (EC:3.4.11.18)
Short name:
MAP 2-1
Short name:
MetAP 2-1
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:Pc14g00010
OrganismiPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
ProteomesiUP000000724: Contig Pc00c14

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Methionine aminopeptidase 2-1UniRule annotation
PRO_0000407632Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi500485.B6H5L5.

Structurei

3D structure databases

ProteinModelPortaliB6H5L5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
HOGENOMiHOG000226278.
KOiK01265.
OMAiNNCVAHY.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6H5L5-1 [UniParc]FASTAAdd to Basket

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MGSKTAENES QGGGNAPPSS TKATATGGEP RGAHWSRDGD GTLGEGEGDD    50
DADGDNTSCA PAVPLNPQTA PSTNSKKRKK RPKKKTSALK QSSPPRIPLA 100
DLFPDHQYPH GEAQVYEPGL ENVARTTADE VRHHSRHHIE DDTFLNDYRK 150
AAEVHRQVRR WTQESVRPGQ TLTEIAMGIE DGVRALLDNA GLDTGQGLIS 200
GLGFPTGLSL NNCVAHYTPN PGQREVVLDS SDVMKVDFGV HINGWIVDSA 250
FTMSFDPTYD NLLAAVKDAT NTGIKNAGVD VRISDVSAAI QEAMESYEVD 300
INGRTFPVKA VRNITGHNIE QYRIHAGKSI PFVKNNDNTK MEEGEIFAIE 350
TFGTTGRGYL FDGPGVYGYG KDPSAPKRIT SHLASAKSLY QKINENFGSL 400
VFCRRYLERL GVESYLAGMN NLVSNGYVEV YQPLMDVRGS YSAQFEHTIL 450
LRESCKEVIS RGDDY 465
Length:465
Mass (Da):50,739
Last modified:December 16, 2008 - v1
Checksum:iB311D49EC02E3C91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74142.1.
RefSeqiXP_002559996.1. XM_002559950.1.

Genome annotation databases

GeneIDi8306312.
KEGGipcs:Pc14g00010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM920429 Genomic DNA. Translation: CAP74142.1 .
RefSeqi XP_002559996.1. XM_002559950.1.

3D structure databases

ProteinModelPortali B6H5L5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 500485.B6H5L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8306312.
KEGGi pcs:Pc14g00010.

Phylogenomic databases

eggNOGi COG0024.
HOGENOMi HOG000226278.
KOi K01265.
OMAi NNCVAHY.
OrthoDBi EOG7BGHW3.

Enzyme and pathway databases

BioCyci PCHR:PC14G00010-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Entry informationi

Entry nameiMAP21_PENCW
AccessioniPrimary (citable) accession number: B6H5L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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