B6H5L5 (AMP2B_PENCW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionine aminopeptidase 2 homolog Pc14g00010
EC=3.4.11.18

Alternative name(s):
Peptidase M 2 homolog Pc14g00010

Gene names

ORF Names:

Pc14g00010

Organism

Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]

Taxonomic identifier

500485 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium › Penicillium chrysogenum complex › Penicillium chrysogenum

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the N-terminal methionine from nascent proteins By similarity.
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Cofactor	Binds 2 cobalt ions per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M24A family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Methionine aminopeptidase 2 homolog Pc14g00010		PRO_0000407632
Sites
	Metal binding	237	1	Cobalt 1 By similarity
	Metal binding	248	1	Cobalt 1 By similarity
	Metal binding	248	1	Cobalt 2 By similarity
	Metal binding	317	1	Cobalt 2 By similarity
	Metal binding	350	1	Cobalt 2 By similarity
	Metal binding	446	1	Cobalt 1 By similarity
	Metal binding	446	1	Cobalt 2 By similarity
	Binding site	216	1	Substrate By similarity
	Binding site	325	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6H5L5 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: B311D49EC02E3C91	FASTA	465	50,739
	10 20 30 40 50 60 MGSKTAENES QGGGNAPPSS TKATATGGEP RGAHWSRDGD GTLGEGEGDD DADGDNTSCA 70 80 90 100 110 120 PAVPLNPQTA PSTNSKKRKK RPKKKTSALK QSSPPRIPLA DLFPDHQYPH GEAQVYEPGL 130 140 150 160 170 180 ENVARTTADE VRHHSRHHIE DDTFLNDYRK AAEVHRQVRR WTQESVRPGQ TLTEIAMGIE 190 200 210 220 230 240 DGVRALLDNA GLDTGQGLIS GLGFPTGLSL NNCVAHYTPN PGQREVVLDS SDVMKVDFGV 250 260 270 280 290 300 HINGWIVDSA FTMSFDPTYD NLLAAVKDAT NTGIKNAGVD VRISDVSAAI QEAMESYEVD 310 320 330 340 350 360 INGRTFPVKA VRNITGHNIE QYRIHAGKSI PFVKNNDNTK MEEGEIFAIE TFGTTGRGYL 370 380 390 400 410 420 FDGPGVYGYG KDPSAPKRIT SHLASAKSLY QKINENFGSL VFCRRYLERL GVESYLAGMN 430 440 450 460 NLVSNGYVEV YQPLMDVRGS YSAQFEHTIL LRESCKEVIS RGDDY

References

[1]

"Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum." van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M., Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M., Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F., Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A. , van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R., Bovenberg R.A.L. Nat. Biotechnol. 26:1161-1168(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 28089 / DSM 1075 / Wisconsin 54-1255.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM920429 Genomic DNA. Translation: CAP74142.1.
RefSeq	XP_002559996.1. XM_002559950.1.
3D structure databases
ProteinModelPortal	B6H5L5.
ModBase	Search...
Protein-protein interaction databases
STRING	500485.B6H5L5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8306312.
KEGG	pcs:Pc14g00010.
Phylogenomic databases
eggNOG	COG0024.
HOGENOM	HOG000226278.
KO	K01265.
OrthoDB	EOG4HB1TZ.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.90.230.10. 2 hits.
InterPro	IPR001714. Pept_M24_MAP. IPR000994. Pept_M24_structural-domain. IPR002468. Pept_M24A_MAP2. IPR018349. Pept_M24A_MAP2_BS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
PANTHER	PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
PRINTS	PR00599. MAPEPTIDASE.
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMs	TIGR00501. met_pdase_II. 1 hit.
PROSITE	PS01202. MAP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMP2B_PENCW

Accession

Primary (citable) accession number: B6H5L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 3, 2011
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program