ID   B6H2P6_PENRW            Unreviewed;       575 AA.
AC   B6H2P6;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Pc13g14950 protein {ECO:0000313|EMBL:CAP92564.1};
GN   ORFNames=Pc13g14950 {ECO:0000313|EMBL:CAP92564.1}, PCH_Pc13g14950
GN   {ECO:0000313|EMBL:CAP92564.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP92564.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP92564.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|ARBA:ARBA00001971,
CC         ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|ARBA:ARBA00005329}.
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DR   EMBL; AM920428; CAP92564.1; -; Genomic_DNA.
DR   RefSeq; XP_002559897.1; XM_002559851.1.
DR   AlphaFoldDB; B6H2P6; -.
DR   STRING; 500485.B6H2P6; -.
DR   GeneID; 8314000; -.
DR   KEGG; pcs:Pc13g14950; -.
DR   VEuPathDB; FungiDB:PCH_Pc13g14950; -.
DR   eggNOG; KOG0047; Eukaryota.
DR   HOGENOM; CLU_010645_0_0_1; -.
DR   OMA; QVTWLFG; -.
DR   OrthoDB; 3198922at2759; -.
DR   BioCyc; PCHR:PC13G14950-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 2.40.180.10; Catalase core domain; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; CATALASE; 1.
DR   PANTHER; PTHR11465:SF13; CATALASE (EUROFUNG); 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038928-2};
KW   Hydrogen peroxide {ECO:0000256|ARBA:ARBA00023324};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR038928-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR038928-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN          60..439
FT                   /note="Catalase core"
FT                   /evidence="ECO:0000259|SMART:SM01060"
FT   REGION          442..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         383
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
SQ   SEQUENCE   575 AA;  64807 MW;  CCBFFE6BB1A6D4ED CRC64;
     MATHPLQAIG EAIGAAGADP RVVQRSSLFQ GANDGPAKTA AKITGVQGIA KRADDGPYFT
     NNEGIPFPDP SHSKTAGGLP LVSDAFLLQK QQHFNRSKNL ERMVHPSEHL GFLRPPRICP
     PLQKSSNIKT PVFVRFSTVT LGREFPDLAR NPRGFAVKFY TGEGNYDLVG LNFPVFFCRD
     PIQGPDVIRS QYRNPKNFLL DYNSLFDLLA NTPEGNHAGL MFFSDHGTPA GWRNQHGYGC
     HTFKWVNASG EFVYVKYHFL VDTGQKQFNA EEALKYGGED PDYSKRDLWS AIEKGEQISY
     TAHVQIMQPD EADPAKLGFD PFDVTKVWPK KQFPLHEFGR LVLNKNPENF HRDVEQAAFS
     PGSMVPGIED SPDPLLQFRM FFYRDAQYHR IGVNLHQVPV NCPFMSSSYS SLNFDGPMRV
     DANHGMNPQY TPNSFTHKFR PDTAETPYQL GDNTVGRKSH FYHEGSPSEY DQPRVLYRDV
     MDDKARAHLH SNTARLLKLV EYTEIQVKYL AQLARIAPGY AKSVYDLLPE KKFDFMEVEQ
     RTGGAERAGK EAKFLPSQET DVLRGSCPMK PVYNV
//