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Protein

Probable cutinase 2

Gene

Pc13g05110

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.By similarity

Catalytic activityi

Cutin + H2O = cutin monomers.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei125 – 1251By similarity
Active sitei180 – 1801By similarity
Active sitei193 – 1931By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciPCHR:PC13G05110-MONOMER.

Protein family/group databases

ESTHERipencw-cuti2. Cutinase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cutinase 2 (EC:3.1.1.74)
Alternative name(s):
Cutin hydrolase 2
Gene namesi
ORF Names:Pc13g05110
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 212196Probable cutinase 2PRO_5000408953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 183By similarity
Disulfide bondi114 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the cutinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYHV. Eukaryota.
ENOG410YI3Y. LUCA.
HOGENOMiHOG000171425.
KOiK08095.
OMAiTRNAQEH.
OrthoDBiEOG779P8P.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6H2E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFKLLSLLL AGLATAGPIE QRQTSSSGNE LRDGPCQPVT FIFARASTEQ
60 70 80 90 100
GLLGGSTGPA VCNDLKSARN QEVACQGVGP KYQATLAANS LPAGTSDEAI
110 120 130 140 150
EEAKGLFEQA ASKCPDTQIV AGGYSQGTAV MHGAIPKLSD AIKDQIKGVV
160 170 180 190 200
LFGDTRNQQD NEQIPDFPKD KTKIYCAVGD QVCHGSLIVA APHFSYVADA
210
GDASRFLVEK LD
Length:212
Mass (Da):22,229
Last modified:December 16, 2008 - v1
Checksum:i10F4139BF8F0C925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920428 Genomic DNA. Translation: CAP91580.1.
RefSeqiXP_002558946.1. XM_002558900.1.

Genome annotation databases

EnsemblFungiiCAP91580; CAP91580; PCH_Pc13g05110.
GeneIDi8312382.
KEGGipcs:Pc13g05110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM920428 Genomic DNA. Translation: CAP91580.1.
RefSeqiXP_002558946.1. XM_002558900.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERipencw-cuti2. Cutinase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP91580; CAP91580; PCH_Pc13g05110.
GeneIDi8312382.
KEGGipcs:Pc13g05110.

Phylogenomic databases

eggNOGiENOG410IYHV. Eukaryota.
ENOG410YI3Y. LUCA.
HOGENOMiHOG000171425.
KOiK08095.
OMAiTRNAQEH.
OrthoDBiEOG779P8P.

Enzyme and pathway databases

BioCyciPCHR:PC13G05110-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255.

Entry informationi

Entry nameiCUTI2_PENRW
AccessioniPrimary (citable) accession number: B6H2E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: May 11, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.