Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B6GW04 (BGALB_PENCW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase B

EC=3.2.1.23
Alternative name(s):
Lactase B
Gene names
Name:lacB
ORF Names:Pc06g00600
OrganismPenicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]
Taxonomic identifier500485 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Protein attributes

Sequence length1013 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Sequence caution

The sequence CAP79053.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 1013992Probable beta-galactosidase B
PRO_5000408640

Sites

Active site1961Proton donor Potential
Active site3081Nucleophile Potential
Binding site901Substrate By similarity
Binding site1351Substrate By similarity
Binding site1361Substrate; via amide nitrogen By similarity
Binding site1371Substrate By similarity
Binding site1951Substrate By similarity
Binding site2651Substrate By similarity
Binding site3731Substrate By similarity

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation7351N-linked (GlcNAc...) Potential
Glycosylation7681N-linked (GlcNAc...) Potential
Glycosylation7751N-linked (GlcNAc...) Potential
Disulfide bond271 ↔ 324 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6GW04 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: A4858AD5E5C13BB2

FASTA1,013111,429
        10         20         30         40         50         60 
MTRILNCLLV LLACLGVSSK AEDQAVTQWP LQDNGLNTVV QWDHYSFQIN GQRIFIFSGE 

        70         80         90        100        110        120 
FHYWRIPVPA LWRDILEKIK AAGFTAFAFY SSWAYHAPNN ATVDFTTGAR DITPIFELAK 

       130        140        150        160        170        180 
ELGMYIIVRP GPYVNAEANA GGFPLWVTTG DYGTLRNDDT RYTNAWTPYF TEVTEITSRY 

       190        200        210        220        230        240 
QVTDGHYSIV YQIENEYGNQ WLGDPTLRVP NETAIAYMEL LKANARDNGI TLPLTVNDPN 

       250        260        270        280        290        300 
MKTHSWGKDW SDAGGNVDVA GLDSYPSCWT CDISQCTSTN GAYVPFQVLE YHDYFQESQP 

       310        320        330        340        350        360 
SMPAFMPEFQ GGSYNPWGGP EGGCPGDIGD DFANLFYRWN IGQRVTAMSL YMMFGGQNPG 

       370        380        390        400        410        420 
AMAAPVTASS YDYSAPISED RSIWSKYHET KLLALFTRSA KDLTMTELMG NGTQYTDNPA 

       430        440        450        460        470        480 
VRAYELRNPE TNSAFYATFH SNTSISTNEP FHLKVNTSAG VLTVPKYAST IRLNGHQSKI 

       490        500        510        520        530        540 
IVTDFTFGSK SLLYSTAEVL TYAVFDKKPT LVLWVPTGES GEFSIKGAKK GSIKKCQGCS 

       550        560        570        580        590        600 
RVKFIKEHGG LTTSLTQSAG MTVLEFDDGV RVILLDRTSA YDFWAPALTN DPFVPETESV 

       610        620        630        640        650        660 
LIQGPYLVRD AKLSGSKLAI TGDVVNATTL DVFAPKGVKS VTWNGKKVDT HSTEYGSLKG 

       670        680        690        700        710        720 
SLDAPQSIKL PALASWKSKD SLPERFADYD DSGAAWVDAN HMTTLNPRTP TSLPVLYADQ 

       730        740        750        760        770        780 
YGFHNGVRLW RGYFNGTATG AFINVQGGSA FGWSAWLNGE FLASHLGNAT TSQANLSLSF 

       790        800        810        820        830        840 
TDATLHTDTP NVLLIVHDDT GHDQTTGALN PRGIMDAKLL GSDSGFTHWR LAGTAGGESD 

       850        860        870        880        890        900 
LDPVRGVYNE DGLFAERVGW HLPGFDDSDW GEEGSAKDST TSVLSFEGAT VRFFRTTCPL 

       910        920        930        940        950        960 
DIPAHTDVSI SFVLSTPAGA TTEYRAQLFV NGYQYGRYNP YIGNQVVYPV PVGILDYKGE 

       970        980        990       1000       1010 
NTIGVAVWAQ SEEGASIGID WRVNYLADSS LDVASWDTKD LRPGWTEERV KYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM920421 Genomic DNA. Translation: CAP79053.1. Sequence problems.
RefSeqXP_002556674.1. XM_002556628.1.

3D structure databases

ProteinModelPortalB6GW04.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING500485.B6GW04.

Protein family/group databases

CAZyGH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8315677.
KEGGpcs:Pc06g00600.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OrthoDBEOG7ZGXBD.

Enzyme and pathway databases

BioCycPCHR:PC06G00600-MONOMER.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALB_PENCW
AccessionPrimary (citable) accession number: B6GW04
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries