Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B6EXY6

- LUP4_ARATH

UniProt

B6EXY6 - LUP4_ARATH

Protein

Beta-amyrin synthase

Gene

BAS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts oxidosqualene to beta-amyrin.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication

    GO - Molecular functioni

    1. beta-amyrin synthase activity Source: TAIR

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-amyrin synthase (EC:5.4.99.39)
    Short name:
    AtBAS
    Alternative name(s):
    Lupeol synthase 4
    Short name:
    AtLUP4
    Gene namesi
    Name:BAS
    Synonyms:LUP4
    Ordered Locus Names:At1g78950
    ORF Names:YUP8H12R.44
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G78950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Beta-amyrin synthasePRO_0000366134Add
    BLAST

    Proteomic databases

    PaxDbiB6EXY6.
    PRIDEiB6EXY6.

    Expressioni

    Gene expression databases

    GenevestigatoriB6EXY6.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G78950.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliB6EXY6.
    SMRiB6EXY6. Positions 99-280, 595-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 19042PFTB 1Add
    BLAST
    Repeati592 – 63241PFTB 2Add
    BLAST
    Repeati641 – 68242PFTB 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 3 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1657.
    HOGENOMiHOG000234317.
    InParanoidiQ3ECA8.
    KOiK15813.
    OMAiFFADIVI.
    PhylomeDBiB6EXY6.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6EXY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRLKIGEGN GDDPYLFTTN NFAGRQTWEF DPDGGSPEER HSVVEARRIF    50
    YDNRFHVKAS SDLLWRMQFL REKKFEQRIA PVKVEDSEKV TFETATSALR 100
    RGIHFFSALQ ASDGHWPAEN AGPLFFLPPL VFCLYITGHL DEVFTSEHRK 150
    EILRYIYCHQ KEDGGWGLHI EGHSTMFCTT LNYICMRILG ESPDGGHDNA 200
    CGRAREWILS HGGVTYIPSW GKTWLSILGV FDWSGSNPMP PEFWILPSFF 250
    PVHPAKMWSY CRMVYLPMSY LYGKRFVGPI TSLILQLRKE LYLQPYEEIN 300
    WMKVRHLCAK EDTYYPRPLV QELVWDSLYI FAEPFLARWP FNKLLREKAL 350
    QLAMKHIHYE DENSRYITIG CVEKVLCMLA CWVEDPNGDY FKKHLSRISD 400
    YLWMAEDGMK MQSFGSQLWD TGFAMQALLA SNLSSEISDV LRRGHEFIKN 450
    SQVGENPSGD YKSMYRHISK GAWTFSDRDH GWQVSDCTAH GLKCCLLFSM 500
    LAPDIVGPKQ DPERLHDSVN ILLSLQSKNG GMTAWEPAGA PKWLELLNPT 550
    EMFSDIVIEH EYSECTSSAI QALSLFKQLY PDHRTTEITA FIKKAAEYLE 600
    NMQTRDGSWY GNWGICFTYG TWFALAGLAA AGKTFNDCEA IRKGVQFLLA 650
    AQKDNGGWGE SYLSCSKKIY IAQVGEISNV VQTAWALMGL IHSGQAERDP 700
    IPLHRAAKLI INSQLESGDF PQQQATGVFL KNCTLHYAAY RNIHPLWALA 750
    EYRARVSLP 759
    Length:759
    Mass (Da):86,953
    Last modified:March 3, 2009 - v2
    Checksum:iE8677A08B251C33D
    GO

    Sequence cautioni

    The sequence AAC17080.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g78950 has been split into 2 genes: At1g78950 and At1g78955.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti334 – 3341P → L in BAG82628. (PubMed:18977664)Curated
    Sequence conflicti544 – 5441L → S in BAG82628. (PubMed:18977664)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB374428 mRNA. Translation: BAG82628.1.
    AC002986 Genomic DNA. Translation: AAC17080.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36183.1.
    PIRiT01060.
    RefSeqiNP_178016.2. NM_106544.4.
    UniGeneiAt.34208.

    Genome annotation databases

    EnsemblPlantsiAT1G78950.1; AT1G78950.1; AT1G78950.
    GeneIDi844234.
    KEGGiath:AT1G78950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB374428 mRNA. Translation: BAG82628.1 .
    AC002986 Genomic DNA. Translation: AAC17080.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36183.1 .
    PIRi T01060.
    RefSeqi NP_178016.2. NM_106544.4.
    UniGenei At.34208.

    3D structure databases

    ProteinModelPortali B6EXY6.
    SMRi B6EXY6. Positions 99-280, 595-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G78950.1-P.

    Proteomic databases

    PaxDbi B6EXY6.
    PRIDEi B6EXY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G78950.1 ; AT1G78950.1 ; AT1G78950 .
    GeneIDi 844234.
    KEGGi ath:AT1G78950.

    Organism-specific databases

    TAIRi AT1G78950.

    Phylogenomic databases

    eggNOGi COG1657.
    HOGENOMi HOG000234317.
    InParanoidi Q3ECA8.
    KOi K15813.
    OMAi FFADIVI.
    PhylomeDBi B6EXY6.

    Gene expression databases

    Genevestigatori B6EXY6.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana."
      Shibuya M., Katsube Y., Otsuka M., Zhang H., Tansakul P., Xiang T., Ebizuka Y.
      Plant Physiol. Biochem. 47:26-30(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana."
      Husselstein-Muller T., Schaller H., Benveniste P.
      Plant Mol. Biol. 45:75-92(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, CATALYTIC ACTIVITY, NOMENCLATURE.

    Entry informationi

    Entry nameiLUP4_ARATH
    AccessioniPrimary (citable) accession number: B6EXY6
    Secondary accession number(s): O64553, Q3ECA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3