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B6EXY6

- LUP4_ARATH

UniProt

B6EXY6 - LUP4_ARATH

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Protein

Beta-amyrin synthase

Gene

BAS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Converts oxidosqualene to beta-amyrin.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.1 Publication

GO - Molecular functioni

  1. beta-amyrin synthase activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_258444. Cholesterol biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-amyrin synthase (EC:5.4.99.39)
Short name:
AtBAS
Alternative name(s):
Lupeol synthase 4
Short name:
AtLUP4
Gene namesi
Name:BAS
Synonyms:LUP4
Ordered Locus Names:At1g78950
ORF Names:YUP8H12R.44
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G78950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Beta-amyrin synthasePRO_0000366134Add
BLAST

Proteomic databases

PaxDbiB6EXY6.
PRIDEiB6EXY6.

Expressioni

Gene expression databases

GenevestigatoriB6EXY6.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G78950.1-P.

Structurei

3D structure databases

ProteinModelPortaliB6EXY6.
SMRiB6EXY6. Positions 99-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 19042PFTB 1Add
BLAST
Repeati592 – 63241PFTB 2Add
BLAST
Repeati641 – 68242PFTB 3Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1657.
HOGENOMiHOG000234317.
KOiK15813.
OMAiFFADIVI.
PhylomeDBiB6EXY6.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6EXY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWRLKIGEGN GDDPYLFTTN NFAGRQTWEF DPDGGSPEER HSVVEARRIF
60 70 80 90 100
YDNRFHVKAS SDLLWRMQFL REKKFEQRIA PVKVEDSEKV TFETATSALR
110 120 130 140 150
RGIHFFSALQ ASDGHWPAEN AGPLFFLPPL VFCLYITGHL DEVFTSEHRK
160 170 180 190 200
EILRYIYCHQ KEDGGWGLHI EGHSTMFCTT LNYICMRILG ESPDGGHDNA
210 220 230 240 250
CGRAREWILS HGGVTYIPSW GKTWLSILGV FDWSGSNPMP PEFWILPSFF
260 270 280 290 300
PVHPAKMWSY CRMVYLPMSY LYGKRFVGPI TSLILQLRKE LYLQPYEEIN
310 320 330 340 350
WMKVRHLCAK EDTYYPRPLV QELVWDSLYI FAEPFLARWP FNKLLREKAL
360 370 380 390 400
QLAMKHIHYE DENSRYITIG CVEKVLCMLA CWVEDPNGDY FKKHLSRISD
410 420 430 440 450
YLWMAEDGMK MQSFGSQLWD TGFAMQALLA SNLSSEISDV LRRGHEFIKN
460 470 480 490 500
SQVGENPSGD YKSMYRHISK GAWTFSDRDH GWQVSDCTAH GLKCCLLFSM
510 520 530 540 550
LAPDIVGPKQ DPERLHDSVN ILLSLQSKNG GMTAWEPAGA PKWLELLNPT
560 570 580 590 600
EMFSDIVIEH EYSECTSSAI QALSLFKQLY PDHRTTEITA FIKKAAEYLE
610 620 630 640 650
NMQTRDGSWY GNWGICFTYG TWFALAGLAA AGKTFNDCEA IRKGVQFLLA
660 670 680 690 700
AQKDNGGWGE SYLSCSKKIY IAQVGEISNV VQTAWALMGL IHSGQAERDP
710 720 730 740 750
IPLHRAAKLI INSQLESGDF PQQQATGVFL KNCTLHYAAY RNIHPLWALA

EYRARVSLP
Length:759
Mass (Da):86,953
Last modified:March 3, 2009 - v2
Checksum:iE8677A08B251C33D
GO

Sequence cautioni

The sequence AAC17080.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At1g78950 has been split into 2 genes: At1g78950 and At1g78955.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti334 – 3341P → L in BAG82628. (PubMed:18977664)Curated
Sequence conflicti544 – 5441L → S in BAG82628. (PubMed:18977664)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374428 mRNA. Translation: BAG82628.1.
AC002986 Genomic DNA. Translation: AAC17080.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36183.1.
PIRiT01060.
RefSeqiNP_178016.2. NM_106544.4.
UniGeneiAt.34208.

Genome annotation databases

EnsemblPlantsiAT1G78950.1; AT1G78950.1; AT1G78950.
GeneIDi844234.
KEGGiath:AT1G78950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374428 mRNA. Translation: BAG82628.1 .
AC002986 Genomic DNA. Translation: AAC17080.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE36183.1 .
PIRi T01060.
RefSeqi NP_178016.2. NM_106544.4.
UniGenei At.34208.

3D structure databases

ProteinModelPortali B6EXY6.
SMRi B6EXY6. Positions 99-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G78950.1-P.

Proteomic databases

PaxDbi B6EXY6.
PRIDEi B6EXY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G78950.1 ; AT1G78950.1 ; AT1G78950 .
GeneIDi 844234.
KEGGi ath:AT1G78950.

Organism-specific databases

TAIRi AT1G78950.

Phylogenomic databases

eggNOGi COG1657.
HOGENOMi HOG000234317.
KOi K15813.
OMAi FFADIVI.
PhylomeDBi B6EXY6.

Enzyme and pathway databases

Reactomei REACT_258444. Cholesterol biosynthesis.

Gene expression databases

Genevestigatori B6EXY6.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana."
    Shibuya M., Katsube Y., Otsuka M., Zhang H., Tansakul P., Xiang T., Ebizuka Y.
    Plant Physiol. Biochem. 47:26-30(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana."
    Husselstein-Muller T., Schaller H., Benveniste P.
    Plant Mol. Biol. 45:75-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, CATALYTIC ACTIVITY, NOMENCLATURE.

Entry informationi

Entry nameiLUP4_ARATH
AccessioniPrimary (citable) accession number: B6EXY6
Secondary accession number(s): O64553, Q3ECA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3