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B6ES35

- GCSP_ALISL

UniProt

B6ES35 - GCSP_ALISL

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:VSAL_II0765
    OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
    Taxonomic identifieri316275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000001730: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000190204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi316275.VSAL_II0765.

    Structurei

    3D structure databases

    ProteinModelPortaliB6ES35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6ES35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQLLQQLGT DNEFIRRHNG PASSQHQHML NTVGAETLEK LIEETVPSSI    50
    RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR 100
    NVFENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL DIANASLLDE 150
    ATAAAEAMTL CKRGGKNKSS TFFVADDVHP QTLAVIKTRA KFIGFDVVVD 200
    TDSNLDSHDV FGALLQYPGT TGEVKDLTTL IEQAHAKKTL VVVATDLLAS 250
    VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 300
    GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH 350
    GPEGLKTIAR RVHHFTAIVA KSLQSAGFEL AHQHFFDTLT VKTEQQTDIL 400
    YTKALAASIN LRKFDTELGI SFDETTTVSD LVALLAVFGV DNAECDSLSN 450
    DIGQDEFAAI PEACRRTSSF LTHPVFNTHH SETQMLRYLK KLENKDFSLT 500
    HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK 550
    SMLCEITGYD DFSLQPNSGA SGEYAGLIAI QRYHESRNEG HRNVCLIPSS 600
    AHGTNPATAS MVSMKVVVVK CDDNGNIDMI DLAEKIAKHQ ENLSSIMITY 650
    PSTHGVYEEQ VREVCDMVHD AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH 700
    LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHSENGVQ GSDYAVSAAD 750
    LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMDRL RPHYPVLYRG 800
    TNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM 850
    IEPTESEDLA ELDRFCEAMI AIREEMNKVQ QGEWPLDNNP LVNAPHTQVD 900
    LMSNEWDHPY TREVACFPSV QAKASKYWPT VNRVDNVYGD RNLICSCPSI 950
    DSYEE 955
    Length:955
    Mass (Da):104,486
    Last modified:November 25, 2008 - v1
    Checksum:iE786273F296B032A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178380 Genomic DNA. Translation: CAQ81519.1.
    RefSeqiWP_012552059.1. NC_011313.1.
    YP_002265075.1. NC_011313.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ81519; CAQ81519; VSAL_II0765.
    GeneIDi6962467.
    KEGGivsa:VSAL_II0765.
    PATRICi20858330. VBIAliSal95923_4125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178380 Genomic DNA. Translation: CAQ81519.1 .
    RefSeqi WP_012552059.1. NC_011313.1.
    YP_002265075.1. NC_011313.1.

    3D structure databases

    ProteinModelPortali B6ES35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316275.VSAL_II0765.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ81519 ; CAQ81519 ; VSAL_II0765 .
    GeneIDi 6962467.
    KEGGi vsa:VSAL_II0765.
    PATRICi 20858330. VBIAliSal95923_4125.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
      Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
      BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LFI1238.

    Entry informationi

    Entry nameiGCSP_ALISL
    AccessioniPrimary (citable) accession number: B6ES35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3