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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VSAL_II0765
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001730 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001902041 – 955Glycine dehydrogenase (decarboxylating)Add BLAST955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei705N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi316275.VSAL_II0765

Structurei

3D structure databases

ProteinModelPortaliB6ES35
SMRiB6ES35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiRELACFP
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

B6ES35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLLQQLGT DNEFIRRHNG PASSQHQHML NTVGAETLEK LIEETVPSSI
60 70 80 90 100
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR
110 120 130 140 150
NVFENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL DIANASLLDE
160 170 180 190 200
ATAAAEAMTL CKRGGKNKSS TFFVADDVHP QTLAVIKTRA KFIGFDVVVD
210 220 230 240 250
TDSNLDSHDV FGALLQYPGT TGEVKDLTTL IEQAHAKKTL VVVATDLLAS
260 270 280 290 300
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI
310 320 330 340 350
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH
360 370 380 390 400
GPEGLKTIAR RVHHFTAIVA KSLQSAGFEL AHQHFFDTLT VKTEQQTDIL
410 420 430 440 450
YTKALAASIN LRKFDTELGI SFDETTTVSD LVALLAVFGV DNAECDSLSN
460 470 480 490 500
DIGQDEFAAI PEACRRTSSF LTHPVFNTHH SETQMLRYLK KLENKDFSLT
510 520 530 540 550
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK
560 570 580 590 600
SMLCEITGYD DFSLQPNSGA SGEYAGLIAI QRYHESRNEG HRNVCLIPSS
610 620 630 640 650
AHGTNPATAS MVSMKVVVVK CDDNGNIDMI DLAEKIAKHQ ENLSSIMITY
660 670 680 690 700
PSTHGVYEEQ VREVCDMVHD AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH
710 720 730 740 750
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHSENGVQ GSDYAVSAAD
760 770 780 790 800
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMDRL RPHYPVLYRG
810 820 830 840 850
TNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM
860 870 880 890 900
IEPTESEDLA ELDRFCEAMI AIREEMNKVQ QGEWPLDNNP LVNAPHTQVD
910 920 930 940 950
LMSNEWDHPY TREVACFPSV QAKASKYWPT VNRVDNVYGD RNLICSCPSI

DSYEE
Length:955
Mass (Da):104,486
Last modified:November 25, 2008 - v1
Checksum:iE786273F296B032A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178380 Genomic DNA Translation: CAQ81519.1
RefSeqiWP_012552059.1, NC_011313.1

Genome annotation databases

EnsemblBacteriaiCAQ81519; CAQ81519; VSAL_II0765
KEGGivsa:VSAL_II0765

Similar proteinsi

Entry informationi

Entry nameiGCSP_ALISL
AccessioniPrimary (citable) accession number: B6ES35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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