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B6ES35 (GCSP_ALISL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:VSAL_II0765
OrganismAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]
Taxonomic identifier316275 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000190204

Amino acid modifications

Modified residue7051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B6ES35 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: E786273F296B032A

FASTA955104,486
        10         20         30         40         50         60 
MSQLLQQLGT DNEFIRRHNG PASSQHQHML NTVGAETLEK LIEETVPSSI RLPQPMQLPH 

        70         80         90        100        110        120 
GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR NVFENPGWYT AYTPYQPEIS 

       130        140        150        160        170        180 
QGRLEALLNY QQMVMDLTGL DIANASLLDE ATAAAEAMTL CKRGGKNKSS TFFVADDVHP 

       190        200        210        220        230        240 
QTLAVIKTRA KFIGFDVVVD TDSNLDSHDV FGALLQYPGT TGEVKDLTTL IEQAHAKKTL 

       250        260        270        280        290        300 
VVVATDLLAS VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 

       310        320        330        340        350        360 
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH GPEGLKTIAR 

       370        380        390        400        410        420 
RVHHFTAIVA KSLQSAGFEL AHQHFFDTLT VKTEQQTDIL YTKALAASIN LRKFDTELGI 

       430        440        450        460        470        480 
SFDETTTVSD LVALLAVFGV DNAECDSLSN DIGQDEFAAI PEACRRTSSF LTHPVFNTHH 

       490        500        510        520        530        540 
SETQMLRYLK KLENKDFSLT HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA 

       550        560        570        580        590        600 
GYTTLATSLK SMLCEITGYD DFSLQPNSGA SGEYAGLIAI QRYHESRNEG HRNVCLIPSS 

       610        620        630        640        650        660 
AHGTNPATAS MVSMKVVVVK CDDNGNIDMI DLAEKIAKHQ ENLSSIMITY PSTHGVYEEQ 

       670        680        690        700        710        720 
VREVCDMVHD AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH LNLHKTFCIP HGGGGPGMGP 

       730        740        750        760        770        780 
IGVKSHLAPF LPGHSENGVQ GSDYAVSAAD LGSASILPIS WAYIAMMGEM GLTEATKVAI 

       790        800        810        820        830        840 
LNANYVMDRL RPHYPVLYRG TNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT 

       850        860        870        880        890        900 
MSFPVAGTLM IEPTESEDLA ELDRFCEAMI AIREEMNKVQ QGEWPLDNNP LVNAPHTQVD 

       910        920        930        940        950 
LMSNEWDHPY TREVACFPSV QAKASKYWPT VNRVDNVYGD RNLICSCPSI DSYEE 

« Hide

References

[1]"The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LFI1238.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM178380 Genomic DNA. Translation: CAQ81519.1.
RefSeqYP_002265075.1. NC_011313.1.

3D structure databases

ProteinModelPortalB6ES35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316275.VSAL_II0765.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ81519; CAQ81519; VSAL_II0765.
GeneID6962467.
KEGGvsa:VSAL_II0765.
PATRIC20858330. VBIAliSal95923_4125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_ALISL
AccessionPrimary (citable) accession number: B6ES35
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families