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B6ES35

- GCSP_ALISL

UniProt

B6ES35 - GCSP_ALISL

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, VSAL_II0765
Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VSAL_II0765
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001730: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000190204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi316275.VSAL_II0765.

Structurei

3D structure databases

ProteinModelPortaliB6ES35.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B6ES35-1 [UniParc]FASTAAdd to Basket

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MSQLLQQLGT DNEFIRRHNG PASSQHQHML NTVGAETLEK LIEETVPSSI    50
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR 100
NVFENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL DIANASLLDE 150
ATAAAEAMTL CKRGGKNKSS TFFVADDVHP QTLAVIKTRA KFIGFDVVVD 200
TDSNLDSHDV FGALLQYPGT TGEVKDLTTL IEQAHAKKTL VVVATDLLAS 250
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 300
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH 350
GPEGLKTIAR RVHHFTAIVA KSLQSAGFEL AHQHFFDTLT VKTEQQTDIL 400
YTKALAASIN LRKFDTELGI SFDETTTVSD LVALLAVFGV DNAECDSLSN 450
DIGQDEFAAI PEACRRTSSF LTHPVFNTHH SETQMLRYLK KLENKDFSLT 500
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK 550
SMLCEITGYD DFSLQPNSGA SGEYAGLIAI QRYHESRNEG HRNVCLIPSS 600
AHGTNPATAS MVSMKVVVVK CDDNGNIDMI DLAEKIAKHQ ENLSSIMITY 650
PSTHGVYEEQ VREVCDMVHD AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH 700
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHSENGVQ GSDYAVSAAD 750
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMDRL RPHYPVLYRG 800
TNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM 850
IEPTESEDLA ELDRFCEAMI AIREEMNKVQ QGEWPLDNNP LVNAPHTQVD 900
LMSNEWDHPY TREVACFPSV QAKASKYWPT VNRVDNVYGD RNLICSCPSI 950
DSYEE 955
Length:955
Mass (Da):104,486
Last modified:November 25, 2008 - v1
Checksum:iE786273F296B032A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178380 Genomic DNA. Translation: CAQ81519.1.
RefSeqiWP_012552059.1. NC_011313.1.
YP_002265075.1. NC_011313.1.

Genome annotation databases

EnsemblBacteriaiCAQ81519; CAQ81519; VSAL_II0765.
GeneIDi6962467.
KEGGivsa:VSAL_II0765.
PATRICi20858330. VBIAliSal95923_4125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178380 Genomic DNA. Translation: CAQ81519.1 .
RefSeqi WP_012552059.1. NC_011313.1.
YP_002265075.1. NC_011313.1.

3D structure databases

ProteinModelPortali B6ES35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316275.VSAL_II0765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ81519 ; CAQ81519 ; VSAL_II0765 .
GeneIDi 6962467.
KEGGi vsa:VSAL_II0765.
PATRICi 20858330. VBIAliSal95923_4125.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
    Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
    BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LFI1238.

Entry informationi

Entry nameiGCSP_ALISL
AccessioniPrimary (citable) accession number: B6ES35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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