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B6ES35

- GCSP_ALISL

UniProt

B6ES35 - GCSP_ALISL

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VSAL_II0765
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001730: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000190204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi316275.VSAL_II0765.

Structurei

3D structure databases

ProteinModelPortaliB6ES35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B6ES35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQLLQQLGT DNEFIRRHNG PASSQHQHML NTVGAETLEK LIEETVPSSI
60 70 80 90 100
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR
110 120 130 140 150
NVFENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL DIANASLLDE
160 170 180 190 200
ATAAAEAMTL CKRGGKNKSS TFFVADDVHP QTLAVIKTRA KFIGFDVVVD
210 220 230 240 250
TDSNLDSHDV FGALLQYPGT TGEVKDLTTL IEQAHAKKTL VVVATDLLAS
260 270 280 290 300
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI
310 320 330 340 350
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH
360 370 380 390 400
GPEGLKTIAR RVHHFTAIVA KSLQSAGFEL AHQHFFDTLT VKTEQQTDIL
410 420 430 440 450
YTKALAASIN LRKFDTELGI SFDETTTVSD LVALLAVFGV DNAECDSLSN
460 470 480 490 500
DIGQDEFAAI PEACRRTSSF LTHPVFNTHH SETQMLRYLK KLENKDFSLT
510 520 530 540 550
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK
560 570 580 590 600
SMLCEITGYD DFSLQPNSGA SGEYAGLIAI QRYHESRNEG HRNVCLIPSS
610 620 630 640 650
AHGTNPATAS MVSMKVVVVK CDDNGNIDMI DLAEKIAKHQ ENLSSIMITY
660 670 680 690 700
PSTHGVYEEQ VREVCDMVHD AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH
710 720 730 740 750
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHSENGVQ GSDYAVSAAD
760 770 780 790 800
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMDRL RPHYPVLYRG
810 820 830 840 850
TNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM
860 870 880 890 900
IEPTESEDLA ELDRFCEAMI AIREEMNKVQ QGEWPLDNNP LVNAPHTQVD
910 920 930 940 950
LMSNEWDHPY TREVACFPSV QAKASKYWPT VNRVDNVYGD RNLICSCPSI

DSYEE
Length:955
Mass (Da):104,486
Last modified:November 25, 2008 - v1
Checksum:iE786273F296B032A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178380 Genomic DNA. Translation: CAQ81519.1.
RefSeqiYP_002265075.1. NC_011313.1.

Genome annotation databases

EnsemblBacteriaiCAQ81519; CAQ81519; VSAL_II0765.
GeneIDi6962467.
KEGGivsa:VSAL_II0765.
PATRICi20858330. VBIAliSal95923_4125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178380 Genomic DNA. Translation: CAQ81519.1 .
RefSeqi YP_002265075.1. NC_011313.1.

3D structure databases

ProteinModelPortali B6ES35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316275.VSAL_II0765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ81519 ; CAQ81519 ; VSAL_II0765 .
GeneIDi 6962467.
KEGGi vsa:VSAL_II0765.
PATRICi 20858330. VBIAliSal95923_4125.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
    Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
    BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LFI1238.

Entry informationi

Entry nameiGCSP_ALISL
AccessioniPrimary (citable) accession number: B6ES35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3