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Reviewed, UniProtKB/Swiss-Prot B6ER09 (GLPK_ALISL)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: VSAL_II0385
OrganismAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]
Taxonomic identifier316275 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

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Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Glycerol kinase HAMAP MF_00186
PRO_1000098711

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site141Substrate By similarity
Binding site181ATP By similarity
Binding site841Substrate By similarity
Binding site1361Substrate By similarity
Binding site2461Substrate By similarity
Binding site2681ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
B6ER09-1 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: F2CBB9B6773B926C

FASTA50455,321
        10         20         30         40         50         60 
MTEQKYIVAL DQGTTSSRAV ILDHDANIVS VSQREFTQIY PQAGWVEHDP LEIYATQSST 

        70         80         90        100        110        120 
LVETLAKAGI RSDQIAAIGI TNQRETTIVW NKETGKPVYN AIVWQCRRTA DTCEKLKEAG 

       130        140        150        160        170        180 
LEEYIRENTG LVVDPYFSGT KIKWILDNVE GAREDAEAGK LLFGTVDTWL VWKMTQGRVH 

       190        200        210        220        230        240 
VTDYTNASRT MVFNINTLQW DEKLLKELDI PLSMMPEVKS SSEVYGETNI GGKGGTRIPI 

       250        260        270        280        290        300 
AGIAGDQQAA LYGQMCVEQG QAKNTYGTGC FLLMNTGKEK VTSRNGLLTT LACGPRGEAS 

       310        320        330        340        350        360 
YALEGAVFMG GASIQWLRDE MKLLADAKDS EYFATKVDSS NGVYVVPAFT GLGAPYWDAY 

       370        380        390        400        410        420 
ARGTIVGLTR GCGSNHIIRA TLESIAYQTR DVIDAMQADS GIKLSALRVD GGAVANNFLM 

       430        440        450        460        470        480 
QFQADVLDVA VHRPQVTEVT ALGAAYLAGL AVGFWGGLDE LAGKAVIDRS FEPHHDEIKR 

       490        500 
NQRYRGWKRA VKCAQSWAEL HDEE

« Hide

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References

[1]"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238."
Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

FM178380 Genomic DNA. Translation: CAQ81139.1.
RefSeqYP_002264723.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6962475.
GenomeReviewsGene locus VSAL_II0385 in contig FM178380_GR.
KEGGvsa:VSAL_II0385.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARQTSGIC.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_ALISL
AccessionPrimary (citable) accession number: B6ER09
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents