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B6ENA8

- PUR9_ALISL

UniProt

B6ENA8 - PUR9_ALISL

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:VSAL_I2842
    OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
    Taxonomic identifieri316275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000001730: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Bifunctional purine biosynthesis protein PurHPRO_1000096037Add
    BLAST

    Proteomic databases

    PRIDEiB6ENA8.

    Interactioni

    Protein-protein interaction databases

    STRINGi316275.VSAL_I2842.

    Structurei

    3D structure databases

    ProteinModelPortaliB6ENA8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6ENA8-1 [UniParc]FASTAAdd to Basket

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    MNNPRPIRRA LISVSDKTGI VEFAQALTER GVDILSTGGT ARLLAEKNIP    50
    VTEVSDYTGF PEMMDGRVKT LHPKVHGGVL GRRGQDDGIM EQHGINPIDI 100
    VVVNLYPFAE TVAKEGCTLA DAVENIDIGG PTMVRSAAKN HKDVTIVVNA 150
    HDYDRVIAEM DTNDKSLTQA TRFDLAIAAF EHTASYDGMI ANYFGTMVPS 200
    YGENKEGDNE SKFPRTFNQQ FEKKQDMRYG ENSHQAAAFY VEANPEEASV 250
    STARQIQGKA LSYNNIADTD AALECVKEFN EPACVIVKHA NPCGVALGKD 300
    VLEAYHRAYQ TDPTSAFGGI IAFNRELDAA TATAITERQF VEVIIAPSVS 350
    AEAIEIIAAK KNLRLLECGE WSTKTTEFDI KRVNGGLLVQ DRDQGMVSED 400
    ELEVVSKRQP TAEELKDALF CWKVAKYVKS NAIVYSKGDM TIGVGAGQMS 450
    RVYSAKIAGI KAADEGLVVE GCAMASDAFF PFRDGIDAAA EAGIKCVIQP 500
    GGSMRDDEVI AAADEHGMAM IFTGMRHFRH 530
    Length:530
    Mass (Da):57,624
    Last modified:November 25, 2008 - v1
    Checksum:i629A91612FCC0E68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178379 Genomic DNA. Translation: CAQ80526.1.
    RefSeqiYP_002264176.1. NC_011312.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ80526; CAQ80526; VSAL_I2842.
    GeneIDi6987941.
    KEGGivsa:VSAL_I2842.
    PATRICi20856198. VBIAliSal95923_3077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178379 Genomic DNA. Translation: CAQ80526.1 .
    RefSeqi YP_002264176.1. NC_011312.1.

    3D structure databases

    ProteinModelPortali B6ENA8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316275.VSAL_I2842.

    Proteomic databases

    PRIDEi B6ENA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ80526 ; CAQ80526 ; VSAL_I2842 .
    GeneIDi 6987941.
    KEGGi vsa:VSAL_I2842.
    PATRICi 20856198. VBIAliSal95923_3077.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
      Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
      BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LFI1238.

    Entry informationi

    Entry nameiPUR9_ALISL
    AccessioniPrimary (citable) accession number: B6ENA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3