Reviewed, UniProtKB/Swiss-Prot B6EN80 (MTLD_ALISL)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	VSAL_I2814

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000099188
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6EN80-1 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 81B963507DDE9D2C	FASTA	382	42,107
	10 20 30 40 50 60 MKAVHFGAGN IGRGFIGKVL SDSNVAVTFA DVDAPLVDQL CHDQSYKVKV VGSKCQIDTV 70 80 90 100 110 120 THVTAVNSTS DDVIERIVHT DLVTTAVGPN VLNIIAKTIA KGLTKRFEAN NESPLNIIAC 130 140 150 160 170 180 ENMVRGTTHL KNEVYSHLDD SFHARCDELV GFVDSAVDRI VPPSEAANDD LLEVTVESFS 190 200 210 220 230 240 EWIVDEKQFK GGVPNIAGME KTDNLMAFVE RKLFTLNTGH CITAYLGALK GHETVRDAIQ 250 260 270 280 290 300 DPEIRTEVKA AMEESGEVLI RRYGFDKELH AAYIEKILGR FANPYLRDEI DRVARQPIRK 310 320 330 340 350 360 LGENDRLIKP LLGTIEYGIE NKTLLKGIAA AFKYVNDTDP QAVELQTHLQ ESGLKATLAH 370 380 YTGLNENSSE AKKIEAIFTT LN

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM178379 Genomic DNA. Translation: CAQ80498.1.
RefSeq	YP_002264148.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6988854.
GenomeReviews	Gene locus VSAL_I2814 in contig FM178379_GR.
KEGG	vsa:VSAL_I2814.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VDRIVPN.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ALISL

Accession

Primary (citable) accession number: B6EN80

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	November 3, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)