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Protein

Argininosuccinate synthase

Gene

argG

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argHA), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei92CitrullineUniRule annotation1
Binding sitei97CitrullineUniRule annotation1
Binding sitei122ATP; via amide nitrogenUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei128CitrullineUniRule annotation1
Binding sitei129AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei181CitrullineUniRule annotation1
Binding sitei190CitrullineUniRule annotation1
Binding sitei266CitrullineUniRule annotation1
Binding sitei278CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:VSAL_I2758
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001730 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000890211 – 403Argininosuccinate synthaseAdd BLAST403

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316275.VSAL_I2758

Structurei

3D structure databases

ProteinModelPortaliB6EMN8
SMRiB6EMN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B6EMN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKVNVNKV VVAYSGGLDT SVIIPWLKEN YDCEVIAFVA DVGQGAEELE
60 70 80 90 100
GIEAKAIASG ASECYVADLK EEMVSEYIFP TLKTGALYEG KYLLGTSMAR
110 120 130 140 150
PIIAKAQVEV ARNVGADALC HGCTGKGNDQ IRFEGAFAAL APDLHVIAPW
160 170 180 190 200
REWDLVSREE CLDYLAERNI PCTASLTKIY SRDANAWHIS TEGGVLEDTW
210 220 230 240 250
NEPNEDCWAW TVDPEQAPNE SETVSIKVEK GAVVAVDGKA MTPYEVVVYL
260 270 280 290 300
NEKGIKHGVG RIDIVENRLV GMKSRGCYET PGGTIINEAL RAVEQLVLDK
310 320 330 340 350
ASFEFREELG IKASHLVYDG RWFTPLCKSI LAATEELAQD VNGDVVIKLY
360 370 380 390 400
KGQATVTQKR SDNSLYSEEF ATFGADEVYD QSHAEGFIRL YSLSSRIRAL

NSK
Length:403
Mass (Da):44,340
Last modified:November 25, 2008 - v1
Checksum:i4BFC2888DC934D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178379 Genomic DNA Translation: CAQ80442.1
RefSeqiWP_012551198.1, NC_011312.1

Genome annotation databases

EnsemblBacteriaiCAQ80442; CAQ80442; VSAL_I2758
KEGGivsa:VSAL_I2758

Similar proteinsi

Entry informationi

Entry nameiASSY_ALISL
AccessioniPrimary (citable) accession number: B6EMN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health