Reviewed, UniProtKB/Swiss-Prot B6EML5 (ASTD_ALISL)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	VSAL_I2735

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000138036
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6EML5-1 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: FC4D41556B53082C	FASTA	485	52,348
	10 20 30 40 50 60 MTHWIAGDWV SGHGETIQSL SPYNSNVVWQ GESATKDQVE SAVSAARHAF IEWKKQPFEA 70 80 90 100 110 120 RQVIIERFAA LVKENTDKIA EVISKETGKP FWETKTEAGA MVGKIAISIR AYHERTPHKE 130 140 150 160 170 180 REAAGNKIVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL AGNTVVLKPS EQTPWTSEVI 190 200 210 220 230 240 MKLWQQAGLP NGVINLVQGA RETGEALASA KGIDGLLFTG SANTGHILHR QFSGDTGKML 250 260 270 280 290 300 ALEMGGNNPM VISKSFGEQE AAVYTIIQSA FISAGQRCTC ARRLYVPIGK AGDELLVRLV 310 320 330 340 350 360 EVAKTIVVDQ PFAENTPFMG PQISIAAAEF ILNAQKNLQD LGGESLLEAK SLGHAFVSPG 370 380 390 400 410 420 IIDATNVAEL PDEEYFGPLL QVVRYETLEE AVELANDTRY GLSAGLVSTD DSEWEYFVEH 430 440 450 460 470 480 IRAGIVNRNR QLTGASGDAP FGGPGASGNM KPSAYYAADY CAYPMASMEG DACEIPAQLS PGLTL

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM178379 Genomic DNA. Translation: CAQ80419.1.
RefSeq	YP_002264071.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6988275.
GenomeReviews	Gene locus VSAL_I2735 in contig FM178379_GR.
KEGG	vsa:VSAL_I2735.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	STDDSEW.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_ALISL

Accession

Primary (citable) accession number: B6EML5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)