Reviewed, UniProtKB/Swiss-Prot B6EM44 (AROB_ALISL)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	VSAL_I2723

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094449

Sequences

	Sequence		Length	Mass (Da)
	B6EM44-1 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: B566200AA9948677	FASTA	362	39,534
	10 20 30 40 50 60 METIHVDLAE RSYPISIGAE LFCNPAHFSS VIPAKKRVVV ISNVTVAPLY AQQIIDTLNT 70 80 90 100 110 120 FECQVSLLEL DDGEQYKNLD TFNQILTFLL EENHSRDVTI VALGGGVVGD VVGFASACYQ 130 140 150 160 170 180 RGVDFIQVPT TLLSQVDSSV GGKTAINHPL GKNMVGAFYQ PKAVIIDINC LKTLPEREFA 190 200 210 220 230 240 AGMAEVIKYG IIIDSDFFDW LDENMEKLYA LDHDALVYAI SRCCQIKADV VAKDEKESGV 250 260 270 280 290 300 RALLNLGHTF GHAIEAEMGY GNWLHGEAVS AGTVMAAVTA QKEGLISQQE VDRICALLKK 310 320 330 340 350 360 AKLPLKAPKE MTVEAFMKHM MRDKKVLSGK LRLVLPTSIG SSEVVTGVSE RVLADVIEQC KA

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM178379 Genomic DNA. Translation: CAQ80407.1.
RefSeq	YP_002264059.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6988264.
GenomeReviews	Gene locus VSAL_I2723 in contig FM178379_GR.
KEGG	vsa:VSAL_I2723.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ALISL

Accession

Primary (citable) accession number: B6EM44

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 25, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)