Reviewed, UniProtKB/Swiss-Prot B6EM15 (GCP_ALISL)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	VSAL_I2694

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_1000145945
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	B6EM15-1 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: E8DAE3787C11EDE5	FASTA	338	36,514
	10 20 30 40 50 60 MRILGIETSC DETGVAIYDD EKGLLAHQLY SQVKLHADYG GVVPELASRD HVKKTIPLIQ 70 80 90 100 110 120 AALNDAGMTK DDIDGIAYTA GPGLVGALLV GSTIGRSIAY AWDVPAIPVH HMEGHLLAPM 130 140 150 160 170 180 LEDNPPEFPF VALLVSGGHT LMVEVKGIGD YQILGESVDD AAGEAFDKTA KLMGLDYPGG 190 200 210 220 230 240 PRLSKLAEAG VKGRFKFPRP MTDRPGLDFS FSGLKTFAAN TIRANDDDEQ TRADIAFAFQ 250 260 270 280 290 300 EAVADTLAIK CRRALKQTGM KRLVMAGGVS ANTYLRQELE AMMKKIGGEV FYPRTEFCTD 310 320 330 NGAMIAYAGM QRLKNGETTD LAVQAKPRWP IDQLAPIK

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM178379 Genomic DNA. Translation: CAQ80378.1.
RefSeq	YP_002264032.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6987883.
GenomeReviews	Gene locus VSAL_I2694 in contig FM178379_GR.
KEGG	vsa:VSAL_I2694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ALISL

Accession

Primary (citable) accession number: B6EM15

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	November 3, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)