Reviewed, UniProtKB/Swiss-Prot B6EKY7 (KHSE_ALISL)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	VSAL_I2555

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Homoserine kinase HAMAP MF_00384		PRO_1000122402
Regions
	Nucleotide binding	97 – 107	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B6EKY7-1 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 98FB58E94753D01A	FASTA	318	34,593
	10 20 30 40 50 60 MSVVVYAPAS IGNVSVGFDV LGAAVSPIDG SLLGDRVLVE SGSDAFTLAT SGRFVDKLPE 70 80 90 100 110 120 NPQDNIVYDC WKVFARELET KNVTLKPIHM VLEKNMPIGS GLGSSACSIV AALDALNQFH 130 140 150 160 170 180 DKPLTEMELL ALMGEMEGQI SGGIHYDNVA PCYLGGLQLM VEELGIISQE VPCFDEWYWV 190 200 210 220 230 240 MAYPGIKVST AEAREILPSQ YRRQDVIAHG RNLAGFIHAC YSKQPELAAK MIKDVVAEPY 250 260 270 280 290 300 RERLLPNFAQ ARAYAASAGA LTTGISGSGP TLFSICKDKD IAERVSRWLQ DNYVQNDEGF 310 VHVCRLDKQG SQVTGSKL

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	FM178379 Genomic DNA. Translation: CAQ80239.1.
RefSeq	YP_002263903.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6989294.
GenomeReviews	Gene locus VSAL_I2555 in contig FM178379_GR.
KEGG	vsa:VSAL_I2555.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CGSAHAD.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_ALISL

Accession

Primary (citable) accession number: B6EKY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)