B6EKQ4 (NAGK_ALISL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-D-glucosamine kinase
EC=2.7.1.59

Alternative name(s):
GlcNAc kinase

Gene names

Name:	nagK
Ordered Locus Names:	VSAL_I1392

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP]

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio › Aliivibrio salmonicida

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity. HAMAP-Rule MF_01271
Catalytic activity	ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP-Rule MF_01271
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_01271
Sequence similarities	Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	N-acetylglucosamine metabolic process Inferred from electronic annotation. Source: HAMAP peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP N-acetylglucosamine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	N-acetyl-D-glucosamine kinase HAMAP-Rule MF_01271		PRO_1000140179
Regions
	Nucleotide binding	4 – 11	8	ATP Potential
	Nucleotide binding	133 – 140	8	ATP Potential
Sites
	Metal binding	157	1	Zinc By similarity
	Metal binding	177	1	Zinc By similarity
	Metal binding	179	1	Zinc By similarity
	Metal binding	184	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6EKQ4 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: F88548B03D7493EE	FASTA	302	32,608
	10 20 30 40 50 60 MYYGFDVGGT KIEFGAFNEK LERVATERIP TQTEDYSLLV NDIASLIAKY DAEFGVEGKV 70 80 90 100 110 120 GLGIPGMEDA ETGALLTSNV PAAKGQFLRK DLEAKIGRSV KIDNDANCFA LSEAWDEELK 130 140 150 160 170 180 DSPSVLGLIL GTGFGGGLVF DGKVFSGYSH VAGELGHSRL PIDAWFHLGE KAPLLECGCG 190 200 210 220 230 240 NKGCIDNYLS GRGFELLYAH YYGQEKKAID IIKANEAGDA DAVEHVDRFM ELLAICFANL 250 260 270 280 290 300 FTCFDPHVVA LGGGLSNFAL IYDELPKRLP KHLLSVARVP RIIKAKHGDS GGVRGAAFLN IK

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LFI1238.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM178379 Genomic DNA. Translation: CAQ79077.1.
RefSeq	YP_002262846.1. NC_011312.1.
3D structure databases
ProteinModelPortal	B6EKQ4.
ModBase	Search...
Protein-protein interaction databases
STRING	316275.VSAL_I1392.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAQ79077; CAQ79077; VSAL_I1392.
GeneID	6987052.
KEGG	vsa:VSAL_I1392.
PATRIC	20853048. VBIAliSal95923_1545.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HOG000150087.
KO	K00884.
OMA	FGHIRLP.
ProtClustDB	PRK13310.
Enzyme and pathway databases
UniPathway	UPA00544.
Family and domain databases
HAMAP	MF_01271. GlcNAc_kinase.
InterPro	IPR023505. N-acetyl-D-glucosamine_kinase. IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGK_ALISL

Accession

Primary (citable) accession number: B6EKQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program