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B6EJW7

- LPXB_ALISL

UniProt

B6EJW7 - LPXB_ALISL

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:VSAL_I2414
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001730: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000191458Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316275.VSAL_I2414.

Structurei

3D structure databases

ProteinModelPortaliB6EJW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B6EJW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPLRIGIV AGELSGDTLG EGFIKSVKAQ YPNAEFVGIG GPKMIAQGCE
60 70 80 90 100
SLFDMEELAV MGLVEVLGRL PRLLKVKAEL VRYFSQNPPD VFIGIDAPDF
110 120 130 140 150
NLRLEKTLKD SGIKTVHYVS PSVWAWRPKR IFKIDAATDL VLAFLPFEKV
160 170 180 190 200
FYDKYNVACE FIGHTLADAI PMQSDKIAAR KLLGLELDRQ WLAVLPGSRG
210 220 230 240 250
GEVALIAKPF IETCQRIHQK HPNMGFVVAA VNEKRREQFE VIWKETAPEL
260 270 280 290 300
KFIIIQDTAR NVMTAADSVL LASGTVALEC MLIKRPMVVG YQVNKLTGWI
310 320 330 340 350
AQKLSITEFV SLPNVLAGKE LVQEFIQEEC HPDFLYPAME KVLSQDNSEL
360 370 380
IDRFTEMHQW IKKDADKQAA NAVLRLINKE TAE
Length:383
Mass (Da):42,929
Last modified:November 25, 2008 - v1
Checksum:i1DEC4146FE77622D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178379 Genomic DNA. Translation: CAQ80098.1.
RefSeqiWP_012550902.1. NC_011312.1.
YP_002263768.1. NC_011312.1.

Genome annotation databases

EnsemblBacteriaiCAQ80098; CAQ80098; VSAL_I2414.
GeneIDi6989138.
KEGGivsa:VSAL_I2414.
PATRICi20855249. VBIAliSal95923_2629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178379 Genomic DNA. Translation: CAQ80098.1 .
RefSeqi WP_012550902.1. NC_011312.1.
YP_002263768.1. NC_011312.1.

3D structure databases

ProteinModelPortali B6EJW7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316275.VSAL_I2414.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ80098 ; CAQ80098 ; VSAL_I2414 .
GeneIDi 6989138.
KEGGi vsa:VSAL_I2414.
PATRICi 20855249. VBIAliSal95923_2629.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
    Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
    BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LFI1238.

Entry informationi

Entry nameiLPXB_ALISL
AccessioniPrimary (citable) accession number: B6EJW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3