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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei621ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VSAL_I0990
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001730 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000912841 – 858Leucine--tRNA ligaseAdd BLAST858

Proteomic databases

PRIDEiB6EIN2

Interactioni

Protein-protein interaction databases

STRINGi316275.VSAL_I0990

Structurei

3D structure databases

ProteinModelPortaliB6EIN2
SMRiB6EIN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi618 – 622"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B6EIN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPQDL EQKIQKHWDD SKTFVVTEDA SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRLQG KNVMQPIGWD AFGLPAENAA VKNKTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WSREFATCTP EYYRWEQEFF TKLYNKGLVY
160 170 180 190 200
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKKIPQ WFIKITEYAQ
210 220 230 240 250
ELLDDLDTLD GWPDMVKTMQ RNWIGRSEGV ELSFAVNGEE APLEVYTTRP
260 270 280 290 300
DTLMGVTYVG IAAGHPLAEQ AAAKNPELFA FTEECRNTKV AEAELATMEK
310 320 330 340 350
KGMDTGLRAI HPLNGREVPI YVANFVLMDY GTGAVMAVPA HDQRDYEFAT
360 370 380 390 400
KYGLDIIPVI KPEDGSDVDV SDVAYTEKGV LFDSGEFDGL AFQDAFDAIA
410 420 430 440 450
AKLEAEGKGK KTVNFRLRDW GVSRQRYWGA PIPMVTTEDG EVHPVPADQL
460 470 480 490 500
PVILPEDVVM DGVTSPIKAD KEWAKTTFNG EPALRETDTF DTFMESSWYY
510 520 530 540 550
ARYCSPQADD ILDPEKANYW LPVDQYVGGI EHACMHLLYS RFFHKLLRDA
560 570 580 590 600
GYVTSNEPFK QLLCQGMVLS DAFHHTNEKG TKEWIAPTDV TIERDAKGRI
610 620 630 640 650
EKAVDDQGRE VQHSGMIKMS KSKNNGIDPQ EMVDKFGADT VRLFMMFAAP
660 670 680 690 700
ADMTLEWQES GVEGASRFLK RVWKLVHEHT TKGTTEALDV AALSGDQKAL
710 720 730 740 750
RRDVHKTIAK VSDDIGRRQT FNTAIAAIME LMNKLNKAPQ GSAQDRALLD
760 770 780 790 800
EALKAVVVML YPMTPHASFA MWEALGESNI DTTAWPTFDE KALIEDEKTI
810 820 830 840 850
VVMINGKLRA KLIVAADATE EQVKELGLND ENALKFLDGL TIRKVIYVPG

KLLNIVAN
Length:858
Mass (Da):96,816
Last modified:November 25, 2008 - v1
Checksum:i68D7F98F624B670D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM178379 Genomic DNA Translation: CAQ78675.1
RefSeqiWP_012549754.1, NC_011312.1

Genome annotation databases

EnsemblBacteriaiCAQ78675; CAQ78675; VSAL_I0990
KEGGivsa:VSAL_I0990

Similar proteinsi

Entry informationi

Entry nameiSYL_ALISL
AccessioniPrimary (citable) accession number: B6EIN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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