B6EIM0 (B6EIM0_ALISL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NADP] EMBL CAQ79890.1
EC=1.1.1.42 EMBL CAQ79890.1

Gene names

Name:	icd EMBL CAQ79890.1
Ordered Locus Names:	VSAL_I2205 EMBL CAQ79890.1

Organism

Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) [Complete proteome] [HAMAP] EMBL CAQ79890.1

Taxonomic identifier

316275 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio › Aliivibrio salmonicida

Protein attributes

Sequence length	742 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL CAQ79890.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	554	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	549	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	B6EIM0 [UniParc]. Last modified November 25, 2008. Version 1. Checksum: 029A917B873688AB	FASTA	742	80,190
	10 20 30 40 50 60 MTTQKSKIIY TITDEAPALA THSLLPIIQA FAASSNVDVD TRDISLAGRV IANFSEYLTE 70 80 90 100 110 120 DQRISDALVE LGELAKTPEA NIIKLPNISA SIPQLHAVIK ELQAKGYALP NYPEEAKTDE 130 140 150 160 170 180 EKTVKAVYDK IKGSAVNPVL REGNSDRRAP GAVKQYARNN PHSMGAWAKD SKSHVASMSE 190 200 210 220 230 240 GDFYASEKSV TIDGATNVNI EFVADNGDVT VLKEGLALKD KEIIDGSCLS KKALVEFFEA 250 260 270 280 290 300 EIKKAKEEDV LLSLHMKATM MKVSDPVIFG HAVKVFYKEV FDKYATTFAK LGVDANNGVG 310 320 330 340 350 360 DVYTKIVSLP DAEKAAIEAD LAAVYEYQPE LAMVDSDRGI TNLHVPSDVI IDASMPAALR 370 380 390 400 410 420 TSGRMWGPDG QLKDTKAMIP DRCYAGVYQS VIEFCKVNGA FDPTTMGSVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFI LPAAGTVRVV DATGTALIEH SVGEGDIWRM CQAKDAPIQD WVKLAVNRAR 490 500 510 520 530 540 ATGTPAIFWL DTNRQHDAEL IKKVNTYLAD HDTSGLDIQI LSPVAATEFT LARIIKGEDT 550 560 570 580 590 600 ISVTGNVLRD YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH 610 620 630 640 650 660 LRWDSLGEFL ALAASFEHLS VTTGNAKAQI LADTLDAATS KFLETNKSPS RRVGELDNRG 670 680 690 700 710 720 SHFYLAMYWA QELAAQTGDA ELQAYFGSLA ETLTSNEAKI VEELNAAQGV VGNVGGYFQP 730 740 IAELAAKEMR PSATLNAALA TL

References

[1]

"The complete genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238." Hjerde E., Lorentzen M.S., Holden M.T.G., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.-P., Thomson N.R. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LFI1238.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM178379 Genomic DNA. Translation: CAQ79890.1.
RefSeq	YP_002263571.1. NC_011312.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	316275.VSAL_I2205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAQ79890; CAQ79890; VSAL_I2205.
GeneID	6989112.
KEGG	vsa:VSAL_I2205.
PATRIC	20854801. VBIAliSal95923_2406.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	FRMCQTK.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B6EIM0_ALISL

Accession

Primary (citable) accession number: B6EIM0

Entry history

Integrated into UniProtKB/TrEMBL:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)