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B6EIM0

- B6EIM0_ALISL

UniProt

B6EIM0 - B6EIM0_ALISL

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Protein
Submitted name:

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese
Metal bindingi554 – 5541Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:VSAL_I2205Imported
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))Imported
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001730: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi316275.VSAL_I2205.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRPSEVFN.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

B6EIM0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTTQKSKIIY TITDEAPALA THSLLPIIQA FAASSNVDVD TRDISLAGRV
60 70 80 90 100
IANFSEYLTE DQRISDALVE LGELAKTPEA NIIKLPNISA SIPQLHAVIK
110 120 130 140 150
ELQAKGYALP NYPEEAKTDE EKTVKAVYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
GAVKQYARNN PHSMGAWAKD SKSHVASMSE GDFYASEKSV TIDGATNVNI
210 220 230 240 250
EFVADNGDVT VLKEGLALKD KEIIDGSCLS KKALVEFFEA EIKKAKEEDV
260 270 280 290 300
LLSLHMKATM MKVSDPVIFG HAVKVFYKEV FDKYATTFAK LGVDANNGVG
310 320 330 340 350
DVYTKIVSLP DAEKAAIEAD LAAVYEYQPE LAMVDSDRGI TNLHVPSDVI
360 370 380 390 400
IDASMPAALR TSGRMWGPDG QLKDTKAMIP DRCYAGVYQS VIEFCKVNGA
410 420 430 440 450
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LPAAGTVRVV DATGTALIEH
460 470 480 490 500
SVGEGDIWRM CQAKDAPIQD WVKLAVNRAR ATGTPAIFWL DTNRQHDAEL
510 520 530 540 550
IKKVNTYLAD HDTSGLDIQI LSPVAATEFT LARIIKGEDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH
610 620 630 640 650
LRWDSLGEFL ALAASFEHLS VTTGNAKAQI LADTLDAATS KFLETNKSPS
660 670 680 690 700
RRVGELDNRG SHFYLAMYWA QELAAQTGDA ELQAYFGSLA ETLTSNEAKI
710 720 730 740
VEELNAAQGV VGNVGGYFQP IAELAAKEMR PSATLNAALA TL
Length:742
Mass (Da):80,190
Last modified:November 25, 2008 - v1
Checksum:i029A917B873688AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178379 Genomic DNA. Translation: CAQ79890.1.
RefSeqiWP_012550721.1. NC_011312.1.
YP_002263571.1. NC_011312.1.

Genome annotation databases

EnsemblBacteriaiCAQ79890; CAQ79890; VSAL_I2205.
GeneIDi6989112.
KEGGivsa:VSAL_I2205.
PATRICi20854801. VBIAliSal95923_2406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178379 Genomic DNA. Translation: CAQ79890.1 .
RefSeqi WP_012550721.1. NC_011312.1.
YP_002263571.1. NC_011312.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316275.VSAL_I2205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ79890 ; CAQ79890 ; VSAL_I2205 .
GeneIDi 6989112.
KEGGi vsa:VSAL_I2205.
PATRICi 20854801. VBIAliSal95923_2406.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi RPSEVFN.
OrthoDBi EOG6DVJPP.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
    Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
    BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LFI1238Imported.

Entry informationi

Entry nameiB6EIM0_ALISL
AccessioniPrimary (citable) accession number: B6EIM0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3