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B6EIM0

- B6EIM0_ALISL

UniProt

B6EIM0 - B6EIM0_ALISL

Protein
Submitted name:

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganese
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganese
    Metal bindingi554 – 5541Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase [NADP]Imported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:VSAL_I2205Imported
    OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))Imported
    Taxonomic identifieri316275 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000001730: Chromosome 1

    Interactioni

    Protein-protein interaction databases

    STRINGi316275.VSAL_I2205.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiRPSEVFN.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6EIM0-1 [UniParc]FASTAAdd to Basket

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    MTTQKSKIIY TITDEAPALA THSLLPIIQA FAASSNVDVD TRDISLAGRV    50
    IANFSEYLTE DQRISDALVE LGELAKTPEA NIIKLPNISA SIPQLHAVIK 100
    ELQAKGYALP NYPEEAKTDE EKTVKAVYDK IKGSAVNPVL REGNSDRRAP 150
    GAVKQYARNN PHSMGAWAKD SKSHVASMSE GDFYASEKSV TIDGATNVNI 200
    EFVADNGDVT VLKEGLALKD KEIIDGSCLS KKALVEFFEA EIKKAKEEDV 250
    LLSLHMKATM MKVSDPVIFG HAVKVFYKEV FDKYATTFAK LGVDANNGVG 300
    DVYTKIVSLP DAEKAAIEAD LAAVYEYQPE LAMVDSDRGI TNLHVPSDVI 350
    IDASMPAALR TSGRMWGPDG QLKDTKAMIP DRCYAGVYQS VIEFCKVNGA 400
    FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LPAAGTVRVV DATGTALIEH 450
    SVGEGDIWRM CQAKDAPIQD WVKLAVNRAR ATGTPAIFWL DTNRQHDAEL 500
    IKKVNTYLAD HDTSGLDIQI LSPVAATEFT LARIIKGEDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQFEKENH 600
    LRWDSLGEFL ALAASFEHLS VTTGNAKAQI LADTLDAATS KFLETNKSPS 650
    RRVGELDNRG SHFYLAMYWA QELAAQTGDA ELQAYFGSLA ETLTSNEAKI 700
    VEELNAAQGV VGNVGGYFQP IAELAAKEMR PSATLNAALA TL 742
    Length:742
    Mass (Da):80,190
    Last modified:November 25, 2008 - v1
    Checksum:i029A917B873688AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178379 Genomic DNA. Translation: CAQ79890.1.
    RefSeqiWP_012550721.1. NC_011312.1.
    YP_002263571.1. NC_011312.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ79890; CAQ79890; VSAL_I2205.
    GeneIDi6989112.
    KEGGivsa:VSAL_I2205.
    PATRICi20854801. VBIAliSal95923_2406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM178379 Genomic DNA. Translation: CAQ79890.1 .
    RefSeqi WP_012550721.1. NC_011312.1.
    YP_002263571.1. NC_011312.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316275.VSAL_I2205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ79890 ; CAQ79890 ; VSAL_I2205 .
    GeneIDi 6989112.
    KEGGi vsa:VSAL_I2205.
    PATRICi 20854801. VBIAliSal95923_2406.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi RPSEVFN.
    OrthoDBi EOG6DVJPP.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
      Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
      BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LFI1238Imported.

    Entry informationi

    Entry nameiB6EIM0_ALISL
    AccessioniPrimary (citable) accession number: B6EIM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3