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B6EIJ9

- FTHS_ALISL

UniProt

B6EIJ9 - FTHS_ALISL

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VSAL_I2184
OrganismiAliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238))
Taxonomic identifieri316275 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001730: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000146671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316275.VSAL_I2184.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCIMHAGP.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6EIJ9 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKSDIEICQT ATLIRMKTIA SNLGLHDDDI TPQGRYKAKV NIDALKHLED
60 70 80 90 100
KPSGKLILVT AITPTPLGEG KTVTTIGLAQ GLAKLGESVS ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAITAAHNLA SAAIDARIYH
160 170 180 190 200
EQRLGYNIFS EKNDLPALRI DPTQVVWKRV MDHNDRALRM VTIGKNEDNK
210 220 230 240 250
TINGYEREDG FDITAASELM AILALATDLQ DLRQRIGRIV VAYNLDGLPI
260 270 280 290 300
TTEDLQVAGA MTVTMKFAIN PTLMQTLEGV PTFVHSGPFA NIAHGNSSII
310 320 330 340 350
ADNIALKLTD YTVLVATLRG IKANSGLFPL SSGQSLPKAL FVPNQEALIA
360 370 380 390 400
GLDNLHWHIK NCAKYGLPVV VAINRFPEDT QEELDFLADW VTSQSSELNL
410 420 430 440 450
DVAISEAFGK GGEGTRELAQ KVLIACAQET EFTPLYTPDM SLLDKLTAVA
460 470 480 490 500
IKGYGAERLE LSEKAQQQLA MFEQLGYQHL SVCMAKTPAS ISTDGNIKGA
510 520 530 540 550
PTDFIVPIRE LRLCAGAGFV YALCGNVMTM PGLPEKPAFM NLDIDSNGNI

TGLS
Length:554
Mass (Da):59,636
Last modified:November 25, 2008 - v1
Checksum:iE33BF504A82F5E27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178379 Genomic DNA. Translation: CAQ79869.1.
RefSeqiYP_002263551.1. NC_011312.1.

Genome annotation databases

EnsemblBacteriaiCAQ79869; CAQ79869; VSAL_I2184.
GeneIDi6987644.
KEGGivsa:VSAL_I2184.
PATRICi20854752. VBIAliSal95923_2382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM178379 Genomic DNA. Translation: CAQ79869.1 .
RefSeqi YP_002263551.1. NC_011312.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316275.VSAL_I2184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ79869 ; CAQ79869 ; VSAL_I2184 .
GeneIDi 6987644.
KEGGi vsa:VSAL_I2184.
PATRICi 20854752. VBIAliSal95923_2382.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi CIMHAGP.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay."
    Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N., Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S., Thurston S., Parkhill J., Willassen N.P., Thomson N.R.
    BMC Genomics 9:616-616(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LFI1238.

Entry informationi

Entry nameiFTHS_ALISL
AccessioniPrimary (citable) accession number: B6EIJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3