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B6DU67

- B6DU67_HUMAN

UniProt

B6DU67 - B6DU67_HUMAN

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Protein
Submitted name: Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  3. sequence-specific DNA binding Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. antral ovarian follicle growth Source: Ensembl
  3. cellular response to estrogen stimulus Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  6. male gonad development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland branching involved in pregnancy Source: Ensembl
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  12. prostate epithelial cord elongation Source: Ensembl
  13. regulation of apoptotic process Source: Ensembl
  14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  15. uterus development Source: Ensembl
  16. vagina development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoformImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiB6DU67.
BgeeiB6DU67.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B6DU67-1 [UniParc]FASTAAdd to Basket

« Hide

GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR RKS          43
Length:43
Mass (Da):5,002
Last modified:November 25, 2008 - v1
Checksum:i37F150573544407A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ169501 mRNA. Translation: ACI04256.1.
UniGeneiHs.208124.
Hs.744830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ169501 mRNA. Translation: ACI04256.1 .
UniGenei Hs.208124.
Hs.744830.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi ESR1. human.
NextBioi 35478348.

Gene expression databases

ArrayExpressi B6DU67.
Bgeei B6DU67.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
PROSITEi PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain."
    Ishunina T.A., Swaab D.F.
    Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Caudal hypothalamusImported.

Entry informationi

Entry nameiB6DU67_HUMAN
AccessioniPrimary (citable) accession number: B6DU67
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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