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Protein

Ferritin

Gene

FTN

Organism
Pseudo-nitzschia multiseries
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron 1Combined sources
Metal bindingi64 – 641Iron 2Combined sources
Metal bindingi65 – 651Iron 1Combined sources
Metal bindingi68 – 681Iron 2Combined sources
Metal bindingi77 – 771Iron 3Combined sources
Metal bindingi77 – 771Zinc 1Combined sources
Metal bindingi102 – 1021Iron 4Combined sources
Metal bindingi106 – 1061Iron 12Combined sources
Metal bindingi106 – 1061Iron 4Combined sources
Metal bindingi106 – 1061Iron 5Combined sources
Metal bindingi106 – 1061Iron 6Combined sources
Metal bindingi106 – 1061Iron 7Combined sources
Metal bindingi106 – 1061Iron 8Combined sources
Metal bindingi106 – 1061Iron 9Combined sources
Metal bindingi106 – 1061Zinc 2Combined sources
Metal bindingi109 – 1091Iron 10Combined sources
Metal bindingi109 – 1091Iron 11Combined sources
Metal bindingi109 – 1091Iron 6Combined sources
Metal bindingi109 – 1091Iron 7Combined sources
Metal bindingi109 – 1091Iron 9Combined sources
Metal bindingi109 – 1091Zinc 2Combined sources
Metal bindingi110 – 1101Iron 12Combined sources
Metal bindingi110 – 1101Iron 3Combined sources
Metal bindingi110 – 1101Iron 8Combined sources
Metal bindingi110 – 1101Zinc 1Combined sources
Metal bindingi110 – 1101Zinc 3Combined sources
Metal bindingi110 – 1101Zinc 4Combined sources
Metal bindingi113 – 1131Iron 3; via pros nitrogenCombined sources
Metal bindingi113 – 1131Zinc 1; via pros nitrogenCombined sources
Metal bindingi156 – 1561Iron 12Combined sources
Metal bindingi156 – 1561Iron 8Combined sources
Metal bindingi156 – 1561Zinc 3Combined sources
Metal bindingi156 – 1561Zinc 4Combined sources
Metal bindingi159 – 1591Iron 3Combined sources
Metal bindingi192 – 1921Iron 4Combined sources
Metal bindingi192 – 1921Iron 6Combined sources
Metal bindingi192 – 1921Iron 7Combined sources
Metal bindingi192 – 1921Iron 8Combined sources
Metal bindingi192 – 1921Iron 9Combined sources
Metal bindingi192 – 1921Zinc 2Combined sources
Metal bindingi192 – 1921Zinc 4Combined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Iron storageUniRule annotation

Keywords - Ligandi

Iron, Metal-bindingUniRule annotationCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation (EC:1.16.3.1UniRule annotation)
Gene namesi
Name:FTNImported
OrganismiPseudo-nitzschia multiseriesImported
Taxonomic identifieri37319 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBacillariophytaBacillariophyceaeBacillariophycidaeBacillarialesBacillariaceaePseudo-nitzschia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 230210FerritinSequence analysisPRO_5002841932Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59728N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E6RX-ray2.40A/B/C/D/E/F63-229[»]
3E6SX-ray1.95A/B/C/D/E/F63-229[»]
4ISMX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ISPX-ray2.20A/B/C/D/E/F/G/H63-229[»]
4ITTX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ITWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4IWJX-ray1.95A/B/C/D/E/F/G/H63-229[»]
4IWKX-ray1.65A/B/C/D/E/F63-229[»]
4IXKX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ZKHX-ray1.90A/B/C/D/E/F/G/H63-230[»]
4ZKWX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZKXX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZL5X-ray1.85A/B/C/D/E/F63-230[»]
4ZL6X-ray1.90A/B/C/D/E/F63-230[»]
4ZLWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ZMCX-ray1.90A/B/C/D/E/F/G/H63-229[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB6DMH6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 207148Ferritin-like diironInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation
Contains 1 ferritin-like diiron domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B6DMH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSPFFFLSA LALTLRDSSP SFATAFRLAV TRCARQGIHA PSSSSSSSSR
60 70 80 90 100
CLVASASALA GPSEELLDLF NRQVTQEFTA SQVYLSASIW FDQNDWEGMA
110 120 130 140 150
AYMLAESAEE REHGLGFVDF ANKRNIPIEL QAVPAPVSCA EWSSPEDVWQ
160 170 180 190 200
SILELEQANT RSLLNLAEAA STCHDFAVMA FLNPFHLQQV NEEDKIGSIL
210 220 230
AKVTDENRTP GLLRSLDVVS FLGPCLFRSV
Length:230
Mass (Da):25,199
Last modified:November 25, 2008 - v1
Checksum:i56107F9680350575
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei230 – 2301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ004953 mRNA. Translation: ACI30660.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ004953 mRNA. Translation: ACI30660.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E6RX-ray2.40A/B/C/D/E/F63-229[»]
3E6SX-ray1.95A/B/C/D/E/F63-229[»]
4ISMX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ISPX-ray2.20A/B/C/D/E/F/G/H63-229[»]
4ITTX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ITWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4IWJX-ray1.95A/B/C/D/E/F/G/H63-229[»]
4IWKX-ray1.65A/B/C/D/E/F63-229[»]
4IXKX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ZKHX-ray1.90A/B/C/D/E/F/G/H63-230[»]
4ZKWX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZKXX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZL5X-ray1.85A/B/C/D/E/F63-230[»]
4ZL6X-ray1.90A/B/C/D/E/F63-230[»]
4ZLWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ZMCX-ray1.90A/B/C/D/E/F/G/H63-229[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59728N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiB6DMH6.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB6DMH6_9STRA
AccessioniPrimary (citable) accession number: B6DMH6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: April 13, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.