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Protein

Transmembrane O-methyltransferase

Gene

Tomt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei112 – 1121S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei130 – 1301S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei160 – 1601S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism, Hearing, Neurotransmitter degradation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane O-methyltransferaseImported (EC:2.1.1.6)
Alternative name(s):
Catechol O-methyltransferase 2By similarity
Protein LRTOMT21 Publication
Gene namesi
Name:TomtImported
Synonyms:Comt2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1561509. Tomt.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Transmembrane O-methyltransferasePRO_0000372489Add
BLAST

Proteomic databases

PaxDbiB6CZ62.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036144.

Structurei

3D structure databases

ProteinModelPortaliB6CZ62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4122.
GeneTreeiENSGT00390000011316.
HOGENOMiHOG000046392.
InParanoidiB6CZ62.
OMAiEERAFQY.
OrthoDBiEOG77T154.
PhylomeDBiB6CZ62.
TreeFamiTF329140.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6CZ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAIALAFL PLVVTLLVRY RHHFRLLVRT VLLRSFRDCL SGLRIEERAF
60 70 80 90 100
SYVITHALPG DPGHILTTLD HWSSCCEYLS HMGPIKGQIL MRLVEEKAPA
110 120 130 140 150
CVLELGTHCG YSTLLIARAL PPGSRLLTVE RDSRTAAVAE KVIRLAGFDE
160 170 180 190 200
QMVELIAGSS EEVIPRLRAQ HQLNRADLVL LAHRPRYYLR DLQLLEAHAL
210 220 230 240 250
LPHGATVLAD HVLFPGAPRF LQYTKSCGRY RCRLHHTSLP DFPAIKDGIA

QLTYTGPG
Length:258
Mass (Da):28,864
Last modified:November 25, 2008 - v1
Checksum:iAF1EFE98697A0B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627093 mRNA. Translation: ACF40903.1.
RefSeqiNP_001132966.1. NM_001139494.1.
UniGeneiRn.220283.

Genome annotation databases

EnsembliENSRNOT00000039564; ENSRNOP00000036144; ENSRNOG00000023434.
GeneIDi308868.
KEGGirno:308868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627093 mRNA. Translation: ACF40903.1.
RefSeqiNP_001132966.1. NM_001139494.1.
UniGeneiRn.220283.

3D structure databases

ProteinModelPortaliB6CZ62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036144.

Proteomic databases

PaxDbiB6CZ62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039564; ENSRNOP00000036144; ENSRNOG00000023434.
GeneIDi308868.
KEGGirno:308868.

Organism-specific databases

CTDi220074.
RGDi1561509. Tomt.

Phylogenomic databases

eggNOGiCOG4122.
GeneTreeiENSGT00390000011316.
HOGENOMiHOG000046392.
InParanoidiB6CZ62.
OMAiEERAFQY.
OrthoDBiEOG77T154.
PhylomeDBiB6CZ62.
TreeFamiTF329140.

Miscellaneous databases

NextBioi659690.
PROiB6CZ62.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.

Entry informationi

Entry nameiTOMT_RAT
AccessioniPrimary (citable) accession number: B6CZ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

Caution

Despite its name, the rat TOMT protein does not contain a transmembrane region in contrast to primate orthologs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.