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B6CZ62

- TOMT_RAT

UniProt

B6CZ62 - TOMT_RAT

Protein

Transmembrane O-methyltransferase

Gene

Tomt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei112 – 1121S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei130 – 1301S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei160 – 1601S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. auditory receptor cell development Source: Ensembl
    2. catecholamine catabolic process Source: Ensembl
    3. neurotransmitter catabolic process Source: UniProtKB-KW
    4. sensory perception of sound Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Hearing, Neurotransmitter degradation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane O-methyltransferaseImported (EC:2.1.1.6)
    Alternative name(s):
    Catechol O-methyltransferase 2By similarity
    Protein LRTOMT21 Publication
    Gene namesi
    Name:TomtImported
    Synonyms:Comt2By similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1561509. Tomt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Transmembrane O-methyltransferasePRO_0000372489Add
    BLAST

    Proteomic databases

    PaxDbiB6CZ62.

    Expressioni

    Gene expression databases

    GenevestigatoriB6CZ62.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000036144.

    Structurei

    3D structure databases

    ProteinModelPortaliB6CZ62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1072S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4122.
    GeneTreeiENSGT00390000011316.
    HOGENOMiHOG000046392.
    OMAiIPCLRTQ.
    OrthoDBiEOG77T154.
    PhylomeDBiB6CZ62.
    TreeFamiTF329140.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6CZ62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAIALAFL PLVVTLLVRY RHHFRLLVRT VLLRSFRDCL SGLRIEERAF    50
    SYVITHALPG DPGHILTTLD HWSSCCEYLS HMGPIKGQIL MRLVEEKAPA 100
    CVLELGTHCG YSTLLIARAL PPGSRLLTVE RDSRTAAVAE KVIRLAGFDE 150
    QMVELIAGSS EEVIPRLRAQ HQLNRADLVL LAHRPRYYLR DLQLLEAHAL 200
    LPHGATVLAD HVLFPGAPRF LQYTKSCGRY RCRLHHTSLP DFPAIKDGIA 250
    QLTYTGPG 258
    Length:258
    Mass (Da):28,864
    Last modified:November 25, 2008 - v1
    Checksum:iAF1EFE98697A0B42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627093 mRNA. Translation: ACF40903.1.
    RefSeqiNP_001132966.1. NM_001139494.1.
    UniGeneiRn.220283.

    Genome annotation databases

    EnsembliENSRNOT00000039564; ENSRNOP00000036144; ENSRNOG00000023434.
    GeneIDi308868.
    KEGGirno:308868.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627093 mRNA. Translation: ACF40903.1 .
    RefSeqi NP_001132966.1. NM_001139494.1.
    UniGenei Rn.220283.

    3D structure databases

    ProteinModelPortali B6CZ62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000036144.

    Proteomic databases

    PaxDbi B6CZ62.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000039564 ; ENSRNOP00000036144 ; ENSRNOG00000023434 .
    GeneIDi 308868.
    KEGGi rno:308868.

    Organism-specific databases

    CTDi 791260.
    RGDi 1561509. Tomt.

    Phylogenomic databases

    eggNOGi COG4122.
    GeneTreei ENSGT00390000011316.
    HOGENOMi HOG000046392.
    OMAi IPCLRTQ.
    OrthoDBi EOG77T154.
    PhylomeDBi B6CZ62.
    TreeFami TF329140.

    Miscellaneous databases

    NextBioi 659690.

    Gene expression databases

    Genevestigatori B6CZ62.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiTOMT_RAT
    AccessioniPrimary (citable) accession number: B6CZ62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

    Caution

    Despite its name, the rat TOMT protein does not contain a transmembrane region in contrast to primate orthologs.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3