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B6CZ56 (TOMT_PROCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane O-methyltransferase

EC=2.1.1.6
Alternative name(s):
Catechol O-methyltransferase 2
Protein LRTOMT2
Gene names
Name:LRTOMT
Synonyms:COMT2, TOMT
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Taxonomic identifier379532 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaePropithecus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity. UniProtKB Q8WZ04 UniProtKB P21964

Catalytic activity

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. UniProtKB P21964

Subcellular location

Isoform 1: Membrane; Single-pass membrane protein Potential.

Isoform 2: Cytoplasm By similarity UniProtKB A1Y9I9.

Miscellaneous

In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene. Ref.1

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

Sequence caution

The sequence ACF40897.1 differs from that shown. Reason: Frameshift at position 12.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: B6CZ56-1)

Also known as: C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: B6CZ56-2)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     12-102: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Transmembrane O-methyltransferase
PRO_0000372488

Regions

Transmembrane14 – 3421Helical; Potential
Region122 – 1232S-adenosyl-L-methionine binding By similarity

Sites

Binding site1201S-adenosyl-L-methionine By similarity
Binding site1281S-adenosyl-L-methionine By similarity
Binding site1461S-adenosyl-L-methionine By similarity
Binding site1761S-adenosyl-L-methionine; via amide nitrogen By similarity

Natural variations

Alternative sequence12 – 10291Missing in isoform 2. Ref.1
VSP_053069

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (C) [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 12B1949D04FC4107

FASTA27430,432
        10         20         30         40         50         60 
MGTPWRKRKG ITQVGTMSPA IALAFLPLVV TLLVRYRHYF RLLVGTVLLR SLRDCLSGLR 

        70         80         90        100        110        120 
IEERAFSYVL THALPGDPGH ILTTLDHWSS HCEYLSHMGP VKGQILMRLV EEKAPACVLE 

       130        140        150        160        170        180 
LGTYCGYSTL LIAQALPPGG RLLTVERDPR TAAVAEKLIR LAGFDEHMVE LIVGSSEEVI 

       190        200        210        220        230        240 
PCLRTQYQLS RADLVLLIHR PRCYLRDLQL LEAHALLPAG ATVLADHVLF PGAPRFLQYA 

       250        260        270 
KSCGRYRCRL YHTGLPDFPA IKDGIAQLTY AGPG 

« Hide

Isoform 2 (D) [UniParc].

Checksum: 036F313CF54A0235
Show »

FASTA18320,221

References

[1]"Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans."
Ahmed Z.M., Masmoudi S., Kalay E., Belyantseva I.A., Mosrati M.A., Collin R.W.J., Riazuddin S., Hmani-Aifa M., Venselaar H., Kawar M.N., Tlili A., van der Zwaag B., Khan S.Y., Ayadi L., Riazuddin S.A., Morell R.J., Griffith A.J., Charfedine I. expand/collapse author list , Caylan R., Oostrik J., Karaguzel A., Ghorbel A., Riazuddin S., Friedman T.B., Ayadi H., Kremer H.
Nat. Genet. 40:1335-1340(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU627087 mRNA. Translation: ACF40897.1. Frameshift.
EU627088 mRNA. Translation: ACF40898.1.

3D structure databases

ProteinModelPortalB6CZ56.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
[Graphical view]
PANTHERPTHR10509. PTHR10509. 1 hit.
PfamPF01596. Methyltransf_3. 1 hit.
[Graphical view]
PROSITEPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOMT_PROCO
AccessionPrimary (citable) accession number: B6CZ56
Secondary accession number(s): B6CZ57
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 18 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families