Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6CZ56

- TOMT_PROCO

UniProt

B6CZ56 - TOMT_PROCO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transmembrane O-methyltransferase

Gene

LRTOMT

Organism
Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei128 – 1281S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei146 – 1461S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei176 – 1761S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

GO - Molecular functioni

  1. catechol O-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. neurotransmitter catabolic process Source: UniProtKB-KW
  3. sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism, Hearing, Neurotransmitter degradation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane O-methyltransferaseBy similarity (EC:2.1.1.6)
Alternative name(s):
Catechol O-methyltransferase 2By similarity
Protein LRTOMT21 Publication
Gene namesi
Name:LRTOMT1 Publication
Synonyms:COMT2By similarity, TOMTBy similarity
OrganismiPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Taxonomic identifieri379532 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaePropithecus

Subcellular locationi

Isoform 1 : Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis
Isoform 2 : Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Transmembrane O-methyltransferasePRO_0000372488Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB6CZ56.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 1232S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: B6CZ56-1) [UniParc]FASTAAdd to Basket

Also known as: C1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTPWRKRKG ITQVGTMSPA IALAFLPLVV TLLVRYRHYF RLLVGTVLLR
60 70 80 90 100
SLRDCLSGLR IEERAFSYVL THALPGDPGH ILTTLDHWSS HCEYLSHMGP
110 120 130 140 150
VKGQILMRLV EEKAPACVLE LGTYCGYSTL LIAQALPPGG RLLTVERDPR
160 170 180 190 200
TAAVAEKLIR LAGFDEHMVE LIVGSSEEVI PCLRTQYQLS RADLVLLIHR
210 220 230 240 250
PRCYLRDLQL LEAHALLPAG ATVLADHVLF PGAPRFLQYA KSCGRYRCRL
260 270
YHTGLPDFPA IKDGIAQLTY AGPG
Length:274
Mass (Da):30,432
Last modified:May 5, 2009 - v2
Checksum:i12B1949D04FC4107
GO
Isoform 21 Publication (identifier: B6CZ56-2) [UniParc]FASTAAdd to Basket

Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     12-102: Missing.

Show »
Length:183
Mass (Da):20,221
Checksum:i036F313CF54A0235
GO

Sequence cautioni

The sequence ACF40897.1 differs from that shown. Reason: Frameshift at position 12.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 10291Missing in isoform 2. 1 PublicationVSP_053069Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627087 mRNA. Translation: ACF40897.1. Frameshift.
EU627088 mRNA. Translation: ACF40898.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627087 mRNA. Translation: ACF40897.1 . Frameshift.
EU627088 mRNA. Translation: ACF40898.1 .

3D structure databases

ProteinModelPortali B6CZ56.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10509. PTHR10509. 1 hit.
Pfami PF01596. Methyltransf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51682. SAM_OMT_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: BrainImported.

Entry informationi

Entry nameiTOMT_PROCO
AccessioniPrimary (citable) accession number: B6CZ56
Secondary accession number(s): B6CZ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3