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B6CZ56

- TOMT_PROCO

UniProt

B6CZ56 - TOMT_PROCO

Protein

Transmembrane O-methyltransferase

Gene

LRTOMT

Organism
Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei128 – 1281S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei146 – 1461S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei176 – 1761S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. neurotransmitter catabolic process Source: UniProtKB-KW
    3. sensory perception of sound Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Hearing, Neurotransmitter degradation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane O-methyltransferaseBy similarity (EC:2.1.1.6)
    Alternative name(s):
    Catechol O-methyltransferase 2By similarity
    Protein LRTOMT21 Publication
    Gene namesi
    Name:LRTOMT1 Publication
    Synonyms:COMT2By similarity, TOMTBy similarity
    OrganismiPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
    Taxonomic identifieri379532 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaePropithecus

    Subcellular locationi

    Isoform 1 : Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis
    Isoform 2 : Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Transmembrane O-methyltransferasePRO_0000372488Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB6CZ56.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni122 – 1232S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: B6CZ56-1) [UniParc]FASTAAdd to Basket

    Also known as: C1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTPWRKRKG ITQVGTMSPA IALAFLPLVV TLLVRYRHYF RLLVGTVLLR    50
    SLRDCLSGLR IEERAFSYVL THALPGDPGH ILTTLDHWSS HCEYLSHMGP 100
    VKGQILMRLV EEKAPACVLE LGTYCGYSTL LIAQALPPGG RLLTVERDPR 150
    TAAVAEKLIR LAGFDEHMVE LIVGSSEEVI PCLRTQYQLS RADLVLLIHR 200
    PRCYLRDLQL LEAHALLPAG ATVLADHVLF PGAPRFLQYA KSCGRYRCRL 250
    YHTGLPDFPA IKDGIAQLTY AGPG 274
    Length:274
    Mass (Da):30,432
    Last modified:May 5, 2009 - v2
    Checksum:i12B1949D04FC4107
    GO
    Isoform 21 Publication (identifier: B6CZ56-2) [UniParc]FASTAAdd to Basket

    Also known as: D1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         12-102: Missing.

    Show »
    Length:183
    Mass (Da):20,221
    Checksum:i036F313CF54A0235
    GO

    Sequence cautioni

    The sequence ACF40897.1 differs from that shown. Reason: Frameshift at position 12.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 10291Missing in isoform 2. 1 PublicationVSP_053069Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627087 mRNA. Translation: ACF40897.1. Frameshift.
    EU627088 mRNA. Translation: ACF40898.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627087 mRNA. Translation: ACF40897.1 . Frameshift.
    EU627088 mRNA. Translation: ACF40898.1 .

    3D structure databases

    ProteinModelPortali B6CZ56.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: BrainImported.

    Entry informationi

    Entry nameiTOMT_PROCO
    AccessioniPrimary (citable) accession number: B6CZ56
    Secondary accession number(s): B6CZ57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 20 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3