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B6CZ46

- TOMT_MACMU

UniProt

B6CZ46 - TOMT_MACMU

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Protein

Transmembrane O-methyltransferase

Gene
LRTOMT, COMT2, TOMT
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421S-adenosyl-L-methionine By similarity
Binding sitei150 – 1501S-adenosyl-L-methionine By similarity
Binding sitei168 – 1681S-adenosyl-L-methionine By similarity
Binding sitei198 – 1981S-adenosyl-L-methionine; via amide nitrogen By similarity

GO - Molecular functioni

  1. catechol O-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. neurotransmitter catabolic process Source: UniProtKB-KW
  3. sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism, Hearing, Neurotransmitter degradation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane O-methyltransferase (EC:2.1.1.6)
Alternative name(s):
Catechol O-methyltransferase 2
Protein LRTOMT2
Gene namesi
Name:LRTOMT
Synonyms:COMT2, TOMT
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Isoform 2 : Cytoplasm By similarity By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Transmembrane O-methyltransferasePRO_0000372486Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB6CZ46.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1452S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: B6CZ46-1) [UniParc]FASTAAdd to Basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGTPWRKRKG IAGPGLPNLS CALVLCLSRS QPRTQVGTMS PAIALAFLPL    50
VVTLLVRYRH YFRLLVGTVL LRSLRDCLSG LRIEERAFSY VLTHALPGDP 100
GHILTTLDHW SSHCEYLSHM GPVKGQILMR LVEEKAPACV LELGTYCGYS 150
TLLIAQALPP GGRLLTVERD PRTAAVAEKL IRLAGFDEHM VELIVGSSEE 200
VIPCLRTQYQ LSRADLVLLI HRPRCYLRDL QLLEAHALLP AGATVLADHV 250
LFPGAPRFLQ YAKSCGRYRC RLYHTGLPDF PAIKDGIAQL TYAGPG 296
Length:296
Mass (Da):32,666
Last modified:May 5, 2009 - v2
Checksum:i9CE89610D5E5EF93
GO
Isoform 21 Publication (identifier: B6CZ46-2) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     11-32: Missing.

Show »
Length:274
Mass (Da):30,475
Checksum:i641A9491B2EC4102
GO

Sequence cautioni

The sequence ACF40887.1 differs from that shown. Reason: Frameshift at positions 18 and 31.
The sequence ACF40888.1 differs from that shown. Reason: Frameshift at position 11.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 3222Missing in isoform 2. 1 PublicationVSP_053068Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627077 mRNA. Translation: ACF40887.1. Frameshift.
EU627078 mRNA. Translation: ACF40888.1. Frameshift.
RefSeqiNP_001129574.1. NM_001136102.1.
UniGeneiMmu.17727.

Genome annotation databases

GeneIDi718286.
KEGGimcc:718286.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627077 mRNA. Translation: ACF40887.1 . Frameshift.
EU627078 mRNA. Translation: ACF40888.1 . Frameshift.
RefSeqi NP_001129574.1. NM_001136102.1.
UniGenei Mmu.17727.

3D structure databases

ProteinModelPortali B6CZ46.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 718286.
KEGGi mcc:718286.

Organism-specific databases

CTDi 220074.

Miscellaneous databases

NextBioi 19970910.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10509. PTHR10509. 1 hit.
Pfami PF01596. Methyltransf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51682. SAM_OMT_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiTOMT_MACMU
AccessioniPrimary (citable) accession number: B6CZ46
Secondary accession number(s): B6CZ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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