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B6CZ46

- TOMT_MACMU

UniProt

B6CZ46 - TOMT_MACMU

Protein

Transmembrane O-methyltransferase

Gene

LRTOMT

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei142 – 1421S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei150 – 1501S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei168 – 1681S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei198 – 1981S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. neurotransmitter catabolic process Source: UniProtKB-KW
    3. sensory perception of sound Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Hearing, Neurotransmitter degradation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane O-methyltransferaseBy similarity (EC:2.1.1.6)
    Alternative name(s):
    Catechol O-methyltransferase 2By similarity
    Protein LRTOMT21 Publication
    Gene namesi
    Name:LRTOMT1 Publication
    Synonyms:COMT2By similarity, TOMTBy similarity
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Isoform 1 : Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis
    Isoform 2 : Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Transmembrane O-methyltransferasePRO_0000372486Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB6CZ46.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni144 – 1452S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: B6CZ46-1) [UniParc]FASTAAdd to Basket

    Also known as: B1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTPWRKRKG IAGPGLPNLS CALVLCLSRS QPRTQVGTMS PAIALAFLPL    50
    VVTLLVRYRH YFRLLVGTVL LRSLRDCLSG LRIEERAFSY VLTHALPGDP 100
    GHILTTLDHW SSHCEYLSHM GPVKGQILMR LVEEKAPACV LELGTYCGYS 150
    TLLIAQALPP GGRLLTVERD PRTAAVAEKL IRLAGFDEHM VELIVGSSEE 200
    VIPCLRTQYQ LSRADLVLLI HRPRCYLRDL QLLEAHALLP AGATVLADHV 250
    LFPGAPRFLQ YAKSCGRYRC RLYHTGLPDF PAIKDGIAQL TYAGPG 296
    Length:296
    Mass (Da):32,666
    Last modified:May 5, 2009 - v2
    Checksum:i9CE89610D5E5EF93
    GO
    Isoform 21 Publication (identifier: B6CZ46-2) [UniParc]FASTAAdd to Basket

    Also known as: C1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         11-32: Missing.

    Show »
    Length:274
    Mass (Da):30,475
    Checksum:i641A9491B2EC4102
    GO

    Sequence cautioni

    The sequence ACF40887.1 differs from that shown. Reason: Frameshift at positions 18 and 31.
    The sequence ACF40888.1 differs from that shown. Reason: Frameshift at position 11.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 3222Missing in isoform 2. 1 PublicationVSP_053068Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627077 mRNA. Translation: ACF40887.1. Frameshift.
    EU627078 mRNA. Translation: ACF40888.1. Frameshift.
    RefSeqiNP_001129574.1. NM_001136102.1.
    UniGeneiMmu.17727.

    Genome annotation databases

    GeneIDi718286.
    KEGGimcc:718286.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627077 mRNA. Translation: ACF40887.1 . Frameshift.
    EU627078 mRNA. Translation: ACF40888.1 . Frameshift.
    RefSeqi NP_001129574.1. NM_001136102.1.
    UniGenei Mmu.17727.

    3D structure databases

    ProteinModelPortali B6CZ46.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 718286.
    KEGGi mcc:718286.

    Organism-specific databases

    CTDi 220074.

    Miscellaneous databases

    NextBioi 19970910.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: BrainImported.

    Entry informationi

    Entry nameiTOMT_MACMU
    AccessioniPrimary (citable) accession number: B6CZ46
    Secondary accession number(s): B6CZ47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3