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B6CZ17

- GRK7A_XENLA

UniProt

B6CZ17 - GRK7A_XENLA

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Protein

G protein-coupled receptor kinase 7A

Gene

grk7-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).By similarity

Catalytic activityi

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei218 – 2181ATPPROSITE-ProRule annotation
Active sitei314 – 3141Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2039ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
  3. rhodopsin kinase activity Source: UniProtKB

GO - Biological processi

  1. signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 7A (EC:2.7.11.14, EC:2.7.11.16)
Gene namesi
Name:grk7-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6055238. grk7.

Subcellular locationi

Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548G protein-coupled receptor kinase 7APRO_0000412816Add
BLAST
Propeptidei549 – 5513Removed in mature formBy similarityPRO_0000412817

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361Phosphoserine1 Publication
Modified residuei487 – 4871PhosphoserineBy similarity
Modified residuei548 – 5481Cysteine methyl esterSequence Analysis
Lipidationi548 – 5481S-geranylgeranyl cysteineSequence Analysis

Post-translational modificationi

Autophosphorylated in vitro at Ser-487 By similarity. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.By similarity1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 174118RGSPROSITE-ProRule annotationAdd
BLAST
Domaini189 – 451263Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini452 – 51766AGC-kinase C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi536 – 5394Poly-Gly

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG004532.
KOiK00909.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6CZ17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCDMGGLDNL IANTAYLQAR KNSEGDVKEL QKRRKSLSLP STDVSRKEIK
60 70 80 90 100
ETITLDYQSI CVEQPIGQRL FRDFLGTVSE YKLAEEFLEE VKEWELEEGS
110 120 130 140 150
AKEQLMEKLV SRRFKEPAEG SLNFLGKDLS SRIQQAQSKD MPELILLAKD
160 170 180 190 200
AGNAFLMDAP FQDFQNSPFY DRFLQWKAFE RQPINQKYFY EFRILGKGGF
210 220 230 240 250
GEVCAIQVKN TGQMYACKKL DKKRLKKKNG EKMALLEKEI LEKVHSPFIV
260 270 280 290 300
SLAYAYETKT HLCLVMSLMN GGDLKFHIYN IGEKGIEIKR VIFYSAQICC
310 320 330 340 350
GILHLHSLKI LYRDMKPENV LLDDNGNCRL SDLGLAVKVK EGKPITQRAG
360 370 380 390 400
TNGYMAPEIL TDVDYSYPVD WFAMGCSIYE MIAGHTPFRD PKEKTSKEEV
410 420 430 440 450
KRKTIEDEVV FQHPVFTEEA KDICRLFLAK KPQNRLGSRT NDDDPRKHAF
460 470 480 490 500
FKSINFQRLE AGMVDPPFVP DPSVVYAKDI SDIADFSEVK GIEFDDKDSK
510 520 530 540 550
FFKRFATGAI PISWQKEIID TGLFDELNDP SREATGGGGN SGEKSGVCSI

L
Length:551
Mass (Da):62,693
Last modified:November 25, 2008 - v1
Checksum:i87140A98514D7022
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU621673 mRNA. Translation: ACF28430.1.
RefSeqiNP_001131051.1. NM_001137579.1.
UniGeneiXl.85028.

Genome annotation databases

GeneIDi100192358.
KEGGixla:100192358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU621673 mRNA. Translation: ACF28430.1 .
RefSeqi NP_001131051.1. NM_001137579.1.
UniGenei Xl.85028.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100192358.
KEGGi xla:100192358.

Organism-specific databases

CTDi 100192358.
Xenbasei XB-GENE-6055238. grk7.

Phylogenomic databases

HOVERGENi HBG004532.
KOi K00909.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light."
    Osawa S., Jo R., Weiss E.R.
    J. Neurochem. 107:1314-1324(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION AT SER-36.

Entry informationi

Entry nameiGRK7A_XENLA
AccessioniPrimary (citable) accession number: B6CZ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3