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B6CZ17

- GRK7A_XENLA

UniProt

B6CZ17 - GRK7A_XENLA

Protein

G protein-coupled receptor kinase 7A

Gene

grk7-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).By similarity

    Catalytic activityi

    ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei218 – 2181ATPPROSITE-ProRule annotation
    Active sitei314 – 3141Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2039ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
    3. rhodopsin kinase activity Source: UniProtKB

    GO - Biological processi

    1. signal transduction Source: InterPro
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 7A (EC:2.7.11.14, EC:2.7.11.16)
    Gene namesi
    Name:grk7-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6055238. grk7.

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548G protein-coupled receptor kinase 7APRO_0000412816Add
    BLAST
    Propeptidei549 – 5513Removed in mature formBy similarityPRO_0000412817

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei487 – 4871PhosphoserineBy similarity
    Modified residuei548 – 5481Cysteine methyl esterSequence Analysis
    Lipidationi548 – 5481S-geranylgeranyl cysteineSequence Analysis

    Post-translational modificationi

    Autophosphorylated in vitro at Ser-487 By similarity. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.By similarity1 Publication

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 174118RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 451263Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini452 – 51766AGC-kinase C-terminalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi536 – 5394Poly-Gly

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG004532.
    KOiK00909.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6CZ17-1 [UniParc]FASTAAdd to Basket

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    MCDMGGLDNL IANTAYLQAR KNSEGDVKEL QKRRKSLSLP STDVSRKEIK    50
    ETITLDYQSI CVEQPIGQRL FRDFLGTVSE YKLAEEFLEE VKEWELEEGS 100
    AKEQLMEKLV SRRFKEPAEG SLNFLGKDLS SRIQQAQSKD MPELILLAKD 150
    AGNAFLMDAP FQDFQNSPFY DRFLQWKAFE RQPINQKYFY EFRILGKGGF 200
    GEVCAIQVKN TGQMYACKKL DKKRLKKKNG EKMALLEKEI LEKVHSPFIV 250
    SLAYAYETKT HLCLVMSLMN GGDLKFHIYN IGEKGIEIKR VIFYSAQICC 300
    GILHLHSLKI LYRDMKPENV LLDDNGNCRL SDLGLAVKVK EGKPITQRAG 350
    TNGYMAPEIL TDVDYSYPVD WFAMGCSIYE MIAGHTPFRD PKEKTSKEEV 400
    KRKTIEDEVV FQHPVFTEEA KDICRLFLAK KPQNRLGSRT NDDDPRKHAF 450
    FKSINFQRLE AGMVDPPFVP DPSVVYAKDI SDIADFSEVK GIEFDDKDSK 500
    FFKRFATGAI PISWQKEIID TGLFDELNDP SREATGGGGN SGEKSGVCSI 550
    L 551
    Length:551
    Mass (Da):62,693
    Last modified:November 25, 2008 - v1
    Checksum:i87140A98514D7022
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU621673 mRNA. Translation: ACF28430.1.
    RefSeqiNP_001131051.1. NM_001137579.1.
    UniGeneiXl.85028.

    Genome annotation databases

    GeneIDi100192358.
    KEGGixla:100192358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU621673 mRNA. Translation: ACF28430.1 .
    RefSeqi NP_001131051.1. NM_001137579.1.
    UniGenei Xl.85028.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100192358.
    KEGGi xla:100192358.

    Organism-specific databases

    CTDi 100192358.
    Xenbasei XB-GENE-6055238. grk7.

    Phylogenomic databases

    HOVERGENi HBG004532.
    KOi K00909.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light."
      Osawa S., Jo R., Weiss E.R.
      J. Neurochem. 107:1314-1324(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION AT SER-36.

    Entry informationi

    Entry nameiGRK7A_XENLA
    AccessioniPrimary (citable) accession number: B6CZ17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3