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B6A7Q3 (CDK14_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 14
EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 14
Gene names
Name:CDK14
Synonyms:PFTK1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A By similarity.

Subunit structure

Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: Recruited to the cell membrane by CCNY By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Cyclin-dependent kinase 14
PRO_0000391901

Regions

Domain134 – 418285Protein kinase
Nucleotide binding140 – 1489ATP By similarity

Sites

Active site2551Proton acceptor By similarity
Binding site1631ATP By similarity

Amino acid modifications

Modified residue941Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
B6A7Q3 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: 115F8C2417C713CC

FASTA46852,929
        10         20         30         40         50         60 
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI VLNVISFVFQ ICVTKMSTRN CQGMDSVIKP 

        70         80         90        100        110        120 
LDTIPEDKKV RVQRTQSTFD PFEKPTNQVK RVHSENNACI NFKSSSAGKE SPKVRRHSSP 

       130        140        150        160        170        180 
SSPTSPKFGK ADSYEKLEKL GEGSYATVYK GKSKVNGKLV ALKVIRLQEE EGTPFTAIRE 

       190        200        210        220        230        240 
ASLLKGLKHA NIVLLHDIIH TKETLTLVFE YVHTDLCQYM DKHPGGLHPE NVKLFLFQLL 

       250        260        270        280        290        300 
RGLSYIHQRY ILHRDLKPQN LLISDTGELK LADFGLARAK SVPSHTYSNE VVTLWYRPPD 

       310        320        330        340        350        360 
VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ LERIFLVLGT PNEDTWPGVH 

       370        380        390        400        410        420 
SLPHFKPERF TLYSSKNLRQ AWNKLSYVNH AEDLASKLLQ CSPKNRLSAQ AALSHEYFSD 

       430        440        450        460 
LPPRLWELTD MSSIFTVPNV RLQPESGESM RAFGKNSSYG KSLSNSKH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DP000945 Genomic DNA. Translation: ACI62516.1.
RefSeqNP_001164748.1. NM_001171277.1.
UniGeneOcu.7562.

3D structure databases

ProteinModelPortalB6A7Q3.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000007965.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328634.

Organism-specific databases

CTD5218.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
OrthoDBEOG4CG082.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK14_RABIT
AccessionPrimary (citable) accession number: B6A7Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: November 25, 2008
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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