SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6A7Q3

- CDK14_RABIT

UniProt

B6A7Q3 - CDK14_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cyclin-dependent kinase 14
Gene
CDK14, PFTK1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei163 – 1631ATP By similarity
Active sitei255 – 2551Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi140 – 1489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: UniProtKB
  2. Wnt signaling pathway Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. regulation of canonical Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:CDK14
Synonyms:PFTK1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity
Note: Recruited to the cell membrane by CCNY By similarity.

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Cyclin-dependent kinase 14
PRO_0000391901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007965.

Structurei

3D structure databases

ProteinModelPortaliB6A7Q3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 418285Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6A7Q3-1 [UniParc]FASTAAdd to Basket

« Hide

MCDLIEPQPA EKIGKMKKLR RTLSESFSRI VLNVISFVFQ ICVTKMSTRN    50
CQGMDSVIKP LDTIPEDKKV RVQRTQSTFD PFEKPTNQVK RVHSENNACI 100
NFKSSSAGKE SPKVRRHSSP SSPTSPKFGK ADSYEKLEKL GEGSYATVYK 150
GKSKVNGKLV ALKVIRLQEE EGTPFTAIRE ASLLKGLKHA NIVLLHDIIH 200
TKETLTLVFE YVHTDLCQYM DKHPGGLHPE NVKLFLFQLL RGLSYIHQRY 250
ILHRDLKPQN LLISDTGELK LADFGLARAK SVPSHTYSNE VVTLWYRPPD 300
VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ LERIFLVLGT 350
PNEDTWPGVH SLPHFKPERF TLYSSKNLRQ AWNKLSYVNH AEDLASKLLQ 400
CSPKNRLSAQ AALSHEYFSD LPPRLWELTD MSSIFTVPNV RLQPESGESM 450
RAFGKNSSYG KSLSNSKH 468
Length:468
Mass (Da):52,929
Last modified:November 25, 2008 - v1
Checksum:i115F8C2417C713CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000945 Genomic DNA. Translation: ACI62516.1.
RefSeqiNP_001164748.1. NM_001171277.1.
UniGeneiOcu.7562.

Genome annotation databases

GeneIDi100328634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000945 Genomic DNA. Translation: ACI62516.1 .
RefSeqi NP_001164748.1. NM_001171277.1.
UniGenei Ocu.7562.

3D structure databases

ProteinModelPortali B6A7Q3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000007965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328634.

Organism-specific databases

CTDi 5218.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCDK14_RABIT
AccessioniPrimary (citable) accession number: B6A7Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi