Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

Rleg2_4830

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRLEG395492:GJB3-4896-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Rleg2_4830Imported
Encoded oniPlasmid pRLG201Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)Imported
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008330 Componenti: Plasmid pRLG201

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_4830.

Structurei

3D structure databases

ProteinModelPortaliB6A0D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6A0D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDILVSRT RTNTTAQGAT GYLTIDLAAL GRNYRKLVSM LAPVRAGAVV
60 70 80 90 100
KANAYGLGAE RVATTLYGEG CRHFFVAQFV EAVRLRPTLA RDAQIFVLNG
110 120 130 140 150
LQPGNEIACA ERGIVPVLNS LTQWRQWSAT ARMLKRCLPA VLQFDTGMSR
160 170 180 190 200
LGFPEEERSE LAAALGDGSN VEILFIMSHL ASADDMESDQ NGEQLAEMAR
210 220 230 240 250
IADEFPGFDI SFANSGGVFL GDAYHGVLAR PGIALYGGAP HAGGNNPMEP
260 270 280 290 300
VVSLDVAVVQ TRTVPAGAKV GYGGAHVTQR KMRLATIAAG YADGLPRSLG
310 320 330 340 350
DRGAVYYNDI RLPIVGRVSM DSATVDVSAL PEGALTLGSL VEVLGSNQTL
360 370
EHIARDAGTI SYEILTGLGD RYDKQYR
Length:377
Mass (Da):40,193
Last modified:November 24, 2008 - v1
Checksum:i5BE6DE4C3E44C82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001192 Genomic DNA. Translation: ACI58069.1.
RefSeqiYP_002278809.1. NC_011368.1.

Genome annotation databases

EnsemblBacteriaiACI58069; ACI58069; Rleg2_4830.
KEGGirlt:Rleg2_4830.
PATRICi23122221. VBIRhiLeg95088_0962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001192 Genomic DNA. Translation: ACI58069.1.
RefSeqiYP_002278809.1. NC_011368.1.

3D structure databases

ProteinModelPortaliB6A0D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395492.Rleg2_4830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI58069; ACI58069; Rleg2_4830.
KEGGirlt:Rleg2_4830.
PATRICi23122221. VBIRhiLeg95088_0962.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRLEG395492:GJB3-4896-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of plasmid 1 of Rhizobium leguminosarum bv. trifolii WSM2304."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
    , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM2304Imported.

Entry informationi

Entry nameiB6A0D5_RHILW
AccessioniPrimary (citable) accession number: B6A0D5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 24, 2008
Last sequence update: November 24, 2008
Last modified: March 31, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.