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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotationSAAS annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotationSAAS annotation
Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotationSAAS annotation

Cofactori

heme bUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotationSAAS annotation

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Rleg2_4680Imported
Encoded oniPlasmid pRLG201Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)Imported
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Plasmid pRLG201

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5ZZZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 416PEROXIDASE_4InterPro annotationAdd BLAST287

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZZZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNPADSTGK CPVAHHKAPA ARSNRDWWPN QLNVQILHHN SGRADPLGKA
60 70 80 90 100
FNYAEEFKKL DLDALKQDLH ALMTDSQDWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRITDGRGG AGQGQQRFAP LNSWPDNANL DKARRLLWPI KQKYGNRISW
160 170 180 190 200
ADLLILTGNV ALESMGFKTF GFAGGRADVW EPEELYWGPE GTWLGDERYS
210 220 230 240 250
GERQLAEPLG AVQMGLIYVN PEGPGGNPDP VASARDIRET FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGDP SLIGAEPEGG AIEDQGLGWK SSFGTGVGKD
310 320 330 340 350
AITAGLEVTW SQTPTKWSNY FFENLFAFEW ELTTSPAGAK QWQAKNAEAS
360 370 380 390 400
IPDAYDAGKK HLPTMLTSDL ALRFDPVYEK ISRRFLESPD QFADAFARAW
410 420 430 440 450
FKLTHRDMGP KVRYLGPEVP AEDLIWQDVI PAVDHPLVDD KDIAELKAKV
460 470 480 490 500
LATGLSVQEL VSTAWASAST FRGSDKRGGA NGARIRLAPQ KDWEANQPAQ
510 520 530 540 550
LAKVLGVLEG IRTGFNAAQT GGKKISLADL IVLAGAAGVE KAAAAGGQSV
560 570 580 590 600
SVPFTPGRTD ASEAQTDAHS FAALEPRIDG FRNYVNGKRL QFMKPEEALV
610 620 630 640 650
DRAQLLTLTG PEMTVLVGGL RVLKAGQPEH GVFTSRPETL TNDFFVNLLD
660 670 680 690 700
MGTQWVPAAE EGVYEGRDRK TGAAKWTGTR VDLIFGSHSQ LRAFAEVYGQ
710 720
ADAKEKFVKD FVAAWNKVMN ADRFDLV
Length:727
Mass (Da):79,454
Last modified:November 25, 2008 - v1
Checksum:i78410B25DC5ECA77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001192 Genomic DNA. Translation: ACI57932.1.
RefSeqiWP_012555700.1. NC_011368.1.

Genome annotation databases

EnsemblBacteriaiACI57932; ACI57932; Rleg2_4680.
KEGGirlt:Rleg2_4680.
PATRICi23121907. VBIRhiLeg95088_0805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001192 Genomic DNA. Translation: ACI57932.1.
RefSeqiWP_012555700.1. NC_011368.1.

3D structure databases

ProteinModelPortaliB5ZZZ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI57932; ACI57932; Rleg2_4680.
KEGGirlt:Rleg2_4680.
PATRICi23121907. VBIRhiLeg95088_0805.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB5ZZZ8_RHILW
AccessioniPrimary (citable) accession number: B5ZZZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.