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B5ZYG6

- PYRF_RHILW

UniProt

B5ZYG6 - PYRF_RHILW

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121SubstrateUniRule annotation
    Binding sitei34 – 341SubstrateUniRule annotation
    Active sitei63 – 631Proton donorUniRule annotation
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation
    Binding sitei207 – 2071SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-318-MONOMER.
    RLEG395492:GJB3-4391-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Rleg2_4325
    OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
    Taxonomic identifieri395492 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000008330: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Orotidine 5'-phosphate decarboxylasePRO_1000138551Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi395492.Rleg2_4325.

    Structurei

    3D structure databases

    ProteinModelPortaliB5ZYG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 7010Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226070.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5ZYG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDARERLIVG LDVPTIGEAE KLVSTLGDDI LFYKIGYQLV FAGGLEFARD    50
    LAASGKKIFL DMKLLDIDNT VASGVENIAK MGMSMLTLHA YPKAMKAAVE 100
    AAAGSGLCLL GVTVLTSMDA EDLADAGYSQ DPHSLVLRRA GQARAAGMGG 150
    IVCSAAEAAE VREIVGPDMA IVTPGIRPTG SDHGDQKRVM TPFDALKAGA 200
    THLVVARPIV KAPDPRDAAR AVLNEMVGAL WPANR 235
    Length:235
    Mass (Da):24,641
    Last modified:November 25, 2008 - v1
    Checksum:i578900E2369E8A0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI57583.1.
    RefSeqiWP_012559687.1. NC_011369.1.
    YP_002283809.1. NC_011369.1.

    Genome annotation databases

    EnsemblBacteriaiACI57583; ACI57583; Rleg2_4325.
    GeneIDi6983099.
    KEGGirlt:Rleg2_4325.
    PATRICi23132974. VBIRhiLeg95088_6277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001191 Genomic DNA. Translation: ACI57583.1 .
    RefSeqi WP_012559687.1. NC_011369.1.
    YP_002283809.1. NC_011369.1.

    3D structure databases

    ProteinModelPortali B5ZYG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395492.Rleg2_4325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI57583 ; ACI57583 ; Rleg2_4325 .
    GeneIDi 6983099.
    KEGGi rlt:Rleg2_4325.
    PATRICi 23132974. VBIRhiLeg95088_6277.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226070.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci RETL1328306-WGS:GSTH-318-MONOMER.
    RLEG395492:GJB3-4391-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
      , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WSM2304.

    Entry informationi

    Entry nameiPYRF_RHILW
    AccessioniPrimary (citable) accession number: B5ZYG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3