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Protein

Thymidine kinase

Gene

tdk

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Rleg2_2822Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)Imported
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi395492.Rleg2_2822.

Structurei

3D structure databases

ProteinModelPortaliB5ZYA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
KOiK00857.
OMAiKEQFGWI.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

B5ZYA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFNYST MNAGKSTMLL QASYNYQERG MRTVQLIAAF DERTGRGVIG
60 70 80 90 100
SRIGLEASAI PFEPHEDLFR LIAGLSGEGA PIACVFVDEA HFMTPVHVWQ
110 120 130 140 150
LARVVDRLGI PVMVYGLRTD FQGKLFPASQ ELLAIADEMR EVRTICHCGR
160 170 180 190 200
KATMVVRLDA EGKVLHEGAQ IDVGGNEKYV SLCRRHWDEA MNGAWIAEPV
Length:200
Mass (Da):22,260
Last modified:November 25, 2008 - v1
Checksum:i5861F890752D973D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI56092.1.
RefSeqiWP_012558539.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI56092; ACI56092; Rleg2_2822.
GeneIDi34192478.
KEGGirlt:Rleg2_2822.

Similar proteinsi

Entry informationi

Entry nameiB5ZYA9_RHILW
AccessioniPrimary (citable) accession number: B5ZYA9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported