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B5ZYA2

- FTHS_RHILW

UniProt

B5ZYA2 - FTHS_RHILW

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRLEG395492:GJB3-2851-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Rleg2_2815
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000008330: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_1000196822Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_2815.

Structurei

3D structure databases

ProteinModelPortaliB5ZYA2.
SMRiB5ZYA2. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5ZYA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSIKSDIEI ARAAAKKPIF EIGAKLGIPV EQLVPYGHDK AKVSAEFIAG
60 70 80 90 100
QAGKKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS
110 120 130 140 150
LGPCFGVKGG AAGGGFAQVV PMEDINLHFT GDFHAITSAH NLLAAMIDNH
160 170 180 190 200
IYWGNEENID IRRITWRRVM DMNDRALRSM VSSLGGVANG FPRQGGFDIT
210 220 230 240 250
VASEVMAILC LATDLTDLER RLGDIIIGYR FDRTPVHARD LKADGAMAVL
260 270 280 290 300
LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVTATKT ALKLGDYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK AGLKPDAAVI VATVRALKMN GGVKKDDLGT
360 370 380 390 400
EDVAALKKGC ANLGRHVANV RRFGVPVVVA INHFISDTDA EIAAVKEFVS
410 420 430 440 450
RLGAEAILCR HWALGSAGIE ELAHKVVELA ESGQAKFQPL YGDDISLFEK
460 470 480 490 500
IEIVASKIYH AGEVTADKAV RDQLQTWEEQ GYGKLPVCMA KTQYSFSTDP
510 520 530 540 550
SLRGAPEGHI VTVREVRLSA GAGFVVAITG EIMTMPGLPK SPSAERIFLN

EQGYIEGLF
Length:559
Mass (Da):59,710
Last modified:November 25, 2008 - v1
Checksum:i86E0BDB25343DE72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001191 Genomic DNA. Translation: ACI56085.1.
RefSeqiWP_012558533.1. NC_011369.1.
YP_002282311.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI56085; ACI56085; Rleg2_2815.
GeneIDi6981559.
KEGGirlt:Rleg2_2815.
PATRICi23129772. VBIRhiLeg95088_4704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001191 Genomic DNA. Translation: ACI56085.1 .
RefSeqi WP_012558533.1. NC_011369.1.
YP_002282311.1. NC_011369.1.

3D structure databases

ProteinModelPortali B5ZYA2.
SMRi B5ZYA2. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395492.Rleg2_2815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI56085 ; ACI56085 ; Rleg2_2815 .
GeneIDi 6981559.
KEGGi rlt:Rleg2_2815.
PATRICi 23129772. VBIRhiLeg95088_4704.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RLEG395492:GJB3-2851-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R.
    , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM2304.

Entry informationi

Entry nameiFTHS_RHILW
AccessioniPrimary (citable) accession number: B5ZYA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3