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B5ZXV8 (B5ZXV8_RHILW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Rleg2_1197
OrganismRhizobium leguminosarum bv. trifolii (strain WSM2304) [Complete proteome] [HAMAP]
Taxonomic identifier395492 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region259 – 2635ACP-binding By similarity HAMAP MF_01815

Sites

Active site1211 By similarity HAMAP MF_01815
Active site2581 By similarity HAMAP MF_01815
Active site2881 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B5ZXV8 [UniParc].

Last modified November 25, 2008. Version 1.
Checksum: FC8BEF75528534B3

FASTA33134,881
        10         20         30         40         50         60 
MSNGVQSNMI RSVVRGFGAA LPKRVMTNGD MEAIVDTSDE WIVQRTGIRQ RYVAGDDETT 

        70         80         90        100        110        120 
ASLGEAAARA ALANGGLTPA DIDLIICATS TPDNTFPATS VNIQNRLGMS HGFAFDVQAV 

       130        140        150        160        170        180 
CTGFVYAVTT ADAYIRGGLA KRVLVIGAET FSRILDWNDR TTCVLFGDGA GAIVLEATEG 

       190        200        210        220        230        240 
EGTVADRGVL TAHLRSDGSH KEKLYVDGGP STTGTVGKLR MEGREVFKYA VGMITDVIQA 

       250        260        270        280        290        300 
AFDSTGTTAE DLDWLVPHQA NRRIIDGSAK KLNIDAAKVV ITVDLHGNTS AASIPLALAT 

       310        320        330 
AAGDGRIKKG DLVMLEAMGG GFTWGAVLLR W

« Hide

References

[1]"Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM2304."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Yates R. expand/collapse author list , Ardley J., Tiwari R.P., O'Hara G., Howieson J., Brau L., Reeve W.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WSM2304.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001191 Genomic DNA. Translation: ACI54491.1.
RefSeqYP_002280717.1. NC_011369.1.

3D structure databases

ProteinModelPortalB5ZXV8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5ZXV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6979917.
GenomeReviewsGene locus Rleg2_1197 in contig CP001191_GR.
KEGGrlt:Rleg2_1197.
PATRIC23126310. VBIRhiLeg95088_2996.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMADAYIRGG.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5ZXV8_RHILW
AccessionPrimary (citable) accession number: B5ZXV8
Entry history
Integrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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