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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Rleg2_4138
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294811 – 434Nicotinate phosphoribosyltransferaseAdd BLAST434

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_4138

Structurei

3D structure databases

ProteinModelPortaliB5ZWU4
SMRiB5ZWU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284929
KOiK00763
OMAiKLTMQCA

Family and domain databases

HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B5ZWU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTDIARRV YNHAWKLDPI IRSLIDTDFY KLLMLQMIWK LYPDVNASFT
60 70 80 90 100
LINRTKRVRL ADEIDEGELR EQLDHARTLK LSKKEMIWLA GNSFYGRAQI
110 120 130 140 150
FEPEFLAWLS NFQLPEYELS KKDGQYVLDF HGSWKETTMW EIPALAIVNE
160 170 180 190 200
LRSRSAMRAL GPFTLDVLYA RAKAKMWSKV ERLKELPGLR ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGPAF TGTSNVLLAM DSDLEAVGTN AHELPMVAAA
260 270 280 290 300
LAQTDEQLRN APYKILRDWN KLYGGNLLIV LPDAFGTAAF LRDAPEWVAD
310 320 330 340 350
WTGFRPDSAP PIEGGEKIID WWKKMGRDPR QKLLIFSDGL DVDAIIDTYR
360 370 380 390 400
HFEGRVRMSF GWGTNLTNDF SGCAPTEISG LNPISVVCKV SDADGRPAVK
410 420 430
LSDNPQKATG DPAEVERYLK FFGAEDRIDQ TVLV
Length:434
Mass (Da):49,509
Last modified:November 25, 2008 - v1
Checksum:i91C19449C3BFA88E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA Translation: ACI57400.1
RefSeqiWP_003589251.1, NC_011369.1

Genome annotation databases

EnsemblBacteriaiACI57400; ACI57400; Rleg2_4138
GeneIDi34191362
KEGGirlt:Rleg2_4138

Similar proteinsi

Entry informationi

Entry nameiPNCB_RHILW
AccessioniPrimary (citable) accession number: B5ZWU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health