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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM2304)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:Rleg2_2597
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM2304)
Taxonomic identifieri395492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008330 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalAdd BLAST21
Transmembranei71 – 91HelicalAdd BLAST21
Transmembranei93 – 113HelicalAdd BLAST21
Transmembranei134 – 154HelicalAdd BLAST21
Transmembranei174 – 194HelicalAdd BLAST21
Transmembranei205 – 225HelicalAdd BLAST21
Transmembranei245 – 265HelicalAdd BLAST21
Transmembranei268 – 288HelicalAdd BLAST21
Transmembranei294 – 314HelicalAdd BLAST21
Transmembranei343 – 363HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906621 – 366Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST366

Interactioni

Protein-protein interaction databases

STRINGi395492.Rleg2_2597.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B5ZWJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIWLVELSE YFKFLNLFRY ITFRTGAALF TSALIVFLFG PTIINSLRIR
60 70 80 90 100
QGKGQPIRAD GPQTHFKKAG TPTMGGLMIL AGIVGASLLW ADLSNVYVVA
110 120 130 140 150
TLLVTLGFGA IGFYDDYLKV TKQSHMGFSG KARLGIEFVI AGIAVYFMMR
160 170 180 190 200
TALASGVAGS TFGSSIAFPF FKDFMINIGI MFVVFGGFVI VGAGNAVNLT
210 220 230 240 250
DGLDGLAIVP VMIAAASFGV IAYLAGNVVF ANYLQINFVP GTGELAVVLG
260 270 280 290 300
AVIGAGLGFL WFNAPPAAIF MGDTGSLALG GTIGTVAVAT KHEIVMAIIG
310 320 330 340 350
GLFVMETLSV IIQVGFFKMT GRRVFLMAPI HHHFEKKGWT ESQVVIRFWI
360
IAVGLAMLGL STLKLR
Length:366
Mass (Da):39,050
Last modified:November 25, 2008 - v1
Checksum:iB97D4534B57C9D89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001191 Genomic DNA. Translation: ACI55868.1.
RefSeqiWP_003593357.1. NC_011369.1.

Genome annotation databases

EnsemblBacteriaiACI55868; ACI55868; Rleg2_2597.
GeneIDi34192576.
KEGGirlt:Rleg2_2597.

Similar proteinsi

Entry informationi

Entry nameiMRAY_RHILW
AccessioniPrimary (citable) accession number: B5ZWJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 25, 2008
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families